The effect of brain-derived neurotrophic factor on periodontal furcation defects.
This study aimed to observe the regenerative effect of brain-derived neurotrophic factor (BDNF) in a non-human primate furcation defect model. Class II furcation defects were created in the first and second molars of 8 non-human primates to simulate a clinical situation. The defect was filled with e...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3891769?pdf=render |
| _version_ | 1828388228688773120 |
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| author | Ryo Jimbo Nick Tovar Malvin N Janal Ramy Mousa Charles Marin Daniel Yoo Hellen S Teixeira Rodolfo B Anchieta Estevam A Bonfante Akihiro Konishi Katsuhiro Takeda Hidemi Kurihara Paulo G Coelho |
| author_facet | Ryo Jimbo Nick Tovar Malvin N Janal Ramy Mousa Charles Marin Daniel Yoo Hellen S Teixeira Rodolfo B Anchieta Estevam A Bonfante Akihiro Konishi Katsuhiro Takeda Hidemi Kurihara Paulo G Coelho |
| author_sort | Ryo Jimbo |
| collection | DOAJ |
| description | This study aimed to observe the regenerative effect of brain-derived neurotrophic factor (BDNF) in a non-human primate furcation defect model. Class II furcation defects were created in the first and second molars of 8 non-human primates to simulate a clinical situation. The defect was filled with either, Group A: BDNF (500 µg/ml) in high-molecular weight-hyaluronic acid (HMW-HA), Group B: BDNF (50 µg/ml) in HMW-HA, Group C: HMW-HA acid only, Group D: empty defect, or Group E: BDNF (500 µg/ml) in saline. The healing status for all groups was observed at different time-points with micro computed tomography. The animals were euthanized after 11 weeks, and the tooth-bone specimens were subjected to histologic processing. The results showed that all groups seemed to successfully regenerate the alveolar buccal bone, however, only Group A regenerated the entire periodontal tissue, i.e., alveolar bone, cementum and periodontal ligament. It is suggested that the use of BDNF in combination with a scaffold such as the hyaluronic acid in periodontal furcation defects may be an effective treatment option. |
| first_indexed | 2024-12-10T06:08:04Z |
| format | Article |
| id | doaj.art-c7bef7dd1adb4ffc98145cbf372ed85c |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-10T06:08:04Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-c7bef7dd1adb4ffc98145cbf372ed85c2022-12-22T01:59:38ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0191e8484510.1371/journal.pone.0084845The effect of brain-derived neurotrophic factor on periodontal furcation defects.Ryo JimboNick TovarMalvin N JanalRamy MousaCharles MarinDaniel YooHellen S TeixeiraRodolfo B AnchietaEstevam A BonfanteAkihiro KonishiKatsuhiro TakedaHidemi KuriharaPaulo G CoelhoThis study aimed to observe the regenerative effect of brain-derived neurotrophic factor (BDNF) in a non-human primate furcation defect model. Class II furcation defects were created in the first and second molars of 8 non-human primates to simulate a clinical situation. The defect was filled with either, Group A: BDNF (500 µg/ml) in high-molecular weight-hyaluronic acid (HMW-HA), Group B: BDNF (50 µg/ml) in HMW-HA, Group C: HMW-HA acid only, Group D: empty defect, or Group E: BDNF (500 µg/ml) in saline. The healing status for all groups was observed at different time-points with micro computed tomography. The animals were euthanized after 11 weeks, and the tooth-bone specimens were subjected to histologic processing. The results showed that all groups seemed to successfully regenerate the alveolar buccal bone, however, only Group A regenerated the entire periodontal tissue, i.e., alveolar bone, cementum and periodontal ligament. It is suggested that the use of BDNF in combination with a scaffold such as the hyaluronic acid in periodontal furcation defects may be an effective treatment option.http://europepmc.org/articles/PMC3891769?pdf=render |
| spellingShingle | Ryo Jimbo Nick Tovar Malvin N Janal Ramy Mousa Charles Marin Daniel Yoo Hellen S Teixeira Rodolfo B Anchieta Estevam A Bonfante Akihiro Konishi Katsuhiro Takeda Hidemi Kurihara Paulo G Coelho The effect of brain-derived neurotrophic factor on periodontal furcation defects. PLoS ONE |
| title | The effect of brain-derived neurotrophic factor on periodontal furcation defects. |
| title_full | The effect of brain-derived neurotrophic factor on periodontal furcation defects. |
| title_fullStr | The effect of brain-derived neurotrophic factor on periodontal furcation defects. |
| title_full_unstemmed | The effect of brain-derived neurotrophic factor on periodontal furcation defects. |
| title_short | The effect of brain-derived neurotrophic factor on periodontal furcation defects. |
| title_sort | effect of brain derived neurotrophic factor on periodontal furcation defects |
| url | http://europepmc.org/articles/PMC3891769?pdf=render |
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