Activation of Xist by an evolutionarily conserved function of KDM5C demethylase
Here the authors show eutherian mammals co-opted the histone demethylase KDM5C during sex-chromosome evolution to induce X-chromosome inactivation by upregulating Xist expression selectively in females.
Bibliographic Details
| Main Authors: |
Milan Kumar Samanta,
Srimonta Gayen,
Clair Harris,
Emily Maclary,
Yumie Murata-Nakamura,
Rebecca M. Malcore,
Robert S. Porter,
Patricia M. Garay,
Christina N. Vallianatos,
Paul B. Samollow,
Shigeki Iwase,
Sundeep Kalantry |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2022-05-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-022-30352-1
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