Activation of Xist by an evolutionarily conserved function of KDM5C demethylase
Here the authors show eutherian mammals co-opted the histone demethylase KDM5C during sex-chromosome evolution to induce X-chromosome inactivation by upregulating Xist expression selectively in females.
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-30352-1 |
| _version_ | 1818203681073397760 |
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| author | Milan Kumar Samanta Srimonta Gayen Clair Harris Emily Maclary Yumie Murata-Nakamura Rebecca M. Malcore Robert S. Porter Patricia M. Garay Christina N. Vallianatos Paul B. Samollow Shigeki Iwase Sundeep Kalantry |
| author_facet | Milan Kumar Samanta Srimonta Gayen Clair Harris Emily Maclary Yumie Murata-Nakamura Rebecca M. Malcore Robert S. Porter Patricia M. Garay Christina N. Vallianatos Paul B. Samollow Shigeki Iwase Sundeep Kalantry |
| author_sort | Milan Kumar Samanta |
| collection | DOAJ |
| description | Here the authors show eutherian mammals co-opted the histone demethylase KDM5C during sex-chromosome evolution to induce X-chromosome inactivation by upregulating Xist expression selectively in females. |
| first_indexed | 2024-12-12T03:29:12Z |
| format | Article |
| id | doaj.art-c7bf99de72cb4d26b0b6c0c4c1912e66 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-12T03:29:12Z |
| publishDate | 2022-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-c7bf99de72cb4d26b0b6c0c4c1912e662022-12-22T00:39:58ZengNature PortfolioNature Communications2041-17232022-05-0113111610.1038/s41467-022-30352-1Activation of Xist by an evolutionarily conserved function of KDM5C demethylaseMilan Kumar Samanta0Srimonta Gayen1Clair Harris2Emily Maclary3Yumie Murata-Nakamura4Rebecca M. Malcore5Robert S. Porter6Patricia M. Garay7Christina N. Vallianatos8Paul B. Samollow9Shigeki Iwase10Sundeep Kalantry11Department of Human Genetics, University of Michigan Medical SchoolDepartment of Human Genetics, University of Michigan Medical SchoolDepartment of Human Genetics, University of Michigan Medical SchoolDepartment of Human Genetics, University of Michigan Medical SchoolDepartment of Human Genetics, University of Michigan Medical SchoolDepartment of Human Genetics, University of Michigan Medical SchoolDepartment of Human Genetics, University of Michigan Medical SchoolDepartment of Human Genetics, University of Michigan Medical SchoolDepartment of Human Genetics, University of Michigan Medical SchoolDepartment of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M UniversityDepartment of Human Genetics, University of Michigan Medical SchoolDepartment of Human Genetics, University of Michigan Medical SchoolHere the authors show eutherian mammals co-opted the histone demethylase KDM5C during sex-chromosome evolution to induce X-chromosome inactivation by upregulating Xist expression selectively in females.https://doi.org/10.1038/s41467-022-30352-1 |
| spellingShingle | Milan Kumar Samanta Srimonta Gayen Clair Harris Emily Maclary Yumie Murata-Nakamura Rebecca M. Malcore Robert S. Porter Patricia M. Garay Christina N. Vallianatos Paul B. Samollow Shigeki Iwase Sundeep Kalantry Activation of Xist by an evolutionarily conserved function of KDM5C demethylase Nature Communications |
| title | Activation of Xist by an evolutionarily conserved function of KDM5C demethylase |
| title_full | Activation of Xist by an evolutionarily conserved function of KDM5C demethylase |
| title_fullStr | Activation of Xist by an evolutionarily conserved function of KDM5C demethylase |
| title_full_unstemmed | Activation of Xist by an evolutionarily conserved function of KDM5C demethylase |
| title_short | Activation of Xist by an evolutionarily conserved function of KDM5C demethylase |
| title_sort | activation of xist by an evolutionarily conserved function of kdm5c demethylase |
| url | https://doi.org/10.1038/s41467-022-30352-1 |
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