Endoplasmic Reticulum Stress and Unfolded Protein Response Pathways: Potential for Treating Age-related Retinal Degeneration

Endoplasmic Reticulum Stress and Unfolded Protein Response Pathways: Potential for Treating Age-related Retinal Degeneration

Accumulation of misfolded proteins in the endoplasmic reticulum (ER) and their aggregation impair normal cellular function and can be toxic, leading to cell death. Prolonged expression of misfolded proteins triggers ER stress, which initiates a cascade of reactions called the unfolded protein respon...

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Bibliographic Details
Main Authors: Mohammad Haeri, Barry E Knox
Format: Article
Language:English
Published: Knowledge E 2012-01-01
Series:Journal of Ophthalmic & Vision Research
Subjects:
ER Stress; Unfolded Protein Response; Age-related Retinal Degeneration; Misfolded Protein; Protein Aggregation; Retinal Degenerative Diseases
Online Access:http://www.jovr.org/article.asp?issn=2008-322X;year=2012;volume=7;issue=1;spage=45;epage=59;aulast=Haeri

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http://www.jovr.org/article.asp?issn=2008-322X;year=2012;volume=7;issue=1;spage=45;epage=59;aulast=Haeri

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