Recent Advances in Understanding the Structures of Translesion Synthesis DNA Polymerases

Recent Advances in Understanding the Structures of Translesion Synthesis DNA Polymerases

DNA damage in the template strand causes replication forks to stall because replicative DNA polymerases are unable to efficiently incorporate nucleotides opposite template DNA lesions. To overcome these replication blocks, cells are equipped with multiple translesion synthesis polymerases that have...

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Bibliographic Details
Main Authors: Justin A. Ling, Zach Frevert, M. Todd Washington
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Genes
Subjects:
DNA replication
DNA polymerases
DNA repair
DNA damage
mutagenesis
genome stability
Online Access:https://www.mdpi.com/2073-4425/13/5/915

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