Genome-Wide Gene-Based Multi-Trait Analysis

Genome-Wide Gene-Based Multi-Trait Analysis

Genome-wide association studies focusing on a single phenotype have been broadly conducted to identify genetic variants associated with a complex disease. The commonly applied single variant analysis is limited by failing to consider the complex interactions between variants, which motivated the dev...

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Bibliographic Details
Main Authors: Yamin Deng, Tao He, Ruiling Fang, Shaoyu Li, Hongyan Cao, Yuehua Cui
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Genetics
Subjects:
gene-based association
kernel function
multi-trait
nonlinear effect
p-value combination
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2020.00437/full

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