Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246
p53 gain of function mutants (mutp53) are involved in the pathogenesis of most human cancers. Here, the authors show that mutp53 regulates the tumor microenvironment by inducing the release of specific exosomes containing miR-1246 that once received by macrophages turns them into tumor supportive ma...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2018-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-03224-w |
| _version_ | 1819129679525707776 |
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| author | Tomer Cooks Ioannis S. Pateras Lisa M. Jenkins Keval M. Patel Ana I. Robles James Morris Tim Forshew Ettore Appella Vassilis G. Gorgoulis Curtis C. Harris |
| author_facet | Tomer Cooks Ioannis S. Pateras Lisa M. Jenkins Keval M. Patel Ana I. Robles James Morris Tim Forshew Ettore Appella Vassilis G. Gorgoulis Curtis C. Harris |
| author_sort | Tomer Cooks |
| collection | DOAJ |
| description | p53 gain of function mutants (mutp53) are involved in the pathogenesis of most human cancers. Here, the authors show that mutp53 regulates the tumor microenvironment by inducing the release of specific exosomes containing miR-1246 that once received by macrophages turns them into tumor supportive macrophages. |
| first_indexed | 2024-12-22T08:47:33Z |
| format | Article |
| id | doaj.art-c7c38fedb00642b095bd023227041cc0 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-22T08:47:33Z |
| publishDate | 2018-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-c7c38fedb00642b095bd023227041cc02022-12-21T18:32:04ZengNature PortfolioNature Communications2041-17232018-02-019111510.1038/s41467-018-03224-wMutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246Tomer Cooks0Ioannis S. Pateras1Lisa M. Jenkins2Keval M. Patel3Ana I. Robles4James Morris5Tim Forshew6Ettore Appella7Vassilis G. Gorgoulis8Curtis C. Harris9Laboratory of Human Carcinogenesis, NCI-CCR, National Institutes of HealthMolecular Carcinogenesis Group, Department of Histology and Embryology, School of Medicine, National Kapodistrian University of AthensLaboratory of Cell Biology, National Cancer Institute, National Institutes of HealthAddenbrooke’s HospitalLaboratory of Human Carcinogenesis, NCI-CCR, National Institutes of HealthCancer Research UK, Cambridge Research InstituteUCL Cancer InstituteLaboratory of Cell Biology, National Cancer Institute, National Institutes of HealthMolecular Carcinogenesis Group, Department of Histology and Embryology, School of Medicine, National Kapodistrian University of AthensLaboratory of Human Carcinogenesis, NCI-CCR, National Institutes of Healthp53 gain of function mutants (mutp53) are involved in the pathogenesis of most human cancers. Here, the authors show that mutp53 regulates the tumor microenvironment by inducing the release of specific exosomes containing miR-1246 that once received by macrophages turns them into tumor supportive macrophages.https://doi.org/10.1038/s41467-018-03224-w |
| spellingShingle | Tomer Cooks Ioannis S. Pateras Lisa M. Jenkins Keval M. Patel Ana I. Robles James Morris Tim Forshew Ettore Appella Vassilis G. Gorgoulis Curtis C. Harris Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246 Nature Communications |
| title | Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246 |
| title_full | Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246 |
| title_fullStr | Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246 |
| title_full_unstemmed | Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246 |
| title_short | Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246 |
| title_sort | mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal mir 1246 |
| url | https://doi.org/10.1038/s41467-018-03224-w |
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