Interspecies Chimeric Barriers for Generating Exogenic Organs and Cells for Transplantation
A growing need for organs and novel cell-based therapies has provided a niche for approaches like interspecies chimeras. To generate organs from one donor species in another host species requires techniques such as blastocyst complementation and gene editing to successfully create an embryo that has...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2022-09-01
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| Series: | Cell Transplantation |
| Online Access: | https://doi.org/10.1177/09636897221110525 |
| _version_ | 1818029559814029312 |
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| author | Phoebe Strell Anala Shetty Clifford J. Steer Walter C. Low |
| author_facet | Phoebe Strell Anala Shetty Clifford J. Steer Walter C. Low |
| author_sort | Phoebe Strell |
| collection | DOAJ |
| description | A growing need for organs and novel cell-based therapies has provided a niche for approaches like interspecies chimeras. To generate organs from one donor species in another host species requires techniques such as blastocyst complementation and gene editing to successfully create an embryo that has cells from both the donor and the host. However, the task of developing highly efficacious and competent interspecies chimeras is met by many challenges. These interspecies chimeric barriers impede the formation of chimeras, often leading to lower levels of chimeric competency. The barriers that need to be addressed include the evolutionary distance between species, stage-matching, temporal and spatial synchronization of developmental timing, interspecies cell competition and the survival of pluripotent stem cells and embryos, compatibility of ligand–receptor signaling between species, and the ethical concerns of forming such models. By overcoming the interspecies chimera barriers and creating highly competent chimeras, the technology of organ and cellular generation can be honed and refined to develop fully functioning exogenic organs, tissues, and cells for transplantation. |
| first_indexed | 2024-12-10T05:21:37Z |
| format | Article |
| id | doaj.art-c7c51135bf104ecd9a685251472419db |
| institution | Directory Open Access Journal |
| issn | 1555-3892 |
| language | English |
| last_indexed | 2024-12-10T05:21:37Z |
| publishDate | 2022-09-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Cell Transplantation |
| spelling | doaj.art-c7c51135bf104ecd9a685251472419db2022-12-22T02:00:48ZengSAGE PublishingCell Transplantation1555-38922022-09-013110.1177/09636897221110525Interspecies Chimeric Barriers for Generating Exogenic Organs and Cells for TransplantationPhoebe Strell0Anala Shetty1Clifford J. Steer2Walter C. Low3Stem Cell Institute, University of Minnesota, Twin Cities, Minneapolis, MN, USAMolecular, Cellular, Developmental Biology, and Genetics Graduate Program, University of Minnesota, Twin Cities, Minneapolis, MN, USADepartment of Genetics, Cell Biology and Genetics, University of Minnesota, Twin Cities, Minneapolis, MN, USADepartment of Neurosurgery, University of Minnesota, Twin Cities, Minneapolis, MN, USAA growing need for organs and novel cell-based therapies has provided a niche for approaches like interspecies chimeras. To generate organs from one donor species in another host species requires techniques such as blastocyst complementation and gene editing to successfully create an embryo that has cells from both the donor and the host. However, the task of developing highly efficacious and competent interspecies chimeras is met by many challenges. These interspecies chimeric barriers impede the formation of chimeras, often leading to lower levels of chimeric competency. The barriers that need to be addressed include the evolutionary distance between species, stage-matching, temporal and spatial synchronization of developmental timing, interspecies cell competition and the survival of pluripotent stem cells and embryos, compatibility of ligand–receptor signaling between species, and the ethical concerns of forming such models. By overcoming the interspecies chimera barriers and creating highly competent chimeras, the technology of organ and cellular generation can be honed and refined to develop fully functioning exogenic organs, tissues, and cells for transplantation.https://doi.org/10.1177/09636897221110525 |
| spellingShingle | Phoebe Strell Anala Shetty Clifford J. Steer Walter C. Low Interspecies Chimeric Barriers for Generating Exogenic Organs and Cells for Transplantation Cell Transplantation |
| title | Interspecies Chimeric Barriers for Generating Exogenic Organs and Cells for Transplantation |
| title_full | Interspecies Chimeric Barriers for Generating Exogenic Organs and Cells for Transplantation |
| title_fullStr | Interspecies Chimeric Barriers for Generating Exogenic Organs and Cells for Transplantation |
| title_full_unstemmed | Interspecies Chimeric Barriers for Generating Exogenic Organs and Cells for Transplantation |
| title_short | Interspecies Chimeric Barriers for Generating Exogenic Organs and Cells for Transplantation |
| title_sort | interspecies chimeric barriers for generating exogenic organs and cells for transplantation |
| url | https://doi.org/10.1177/09636897221110525 |
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