Metastatic Primary Testicular Neuroendocrine Carcinoma Associated with Somatic Malignant Transformation of Teratoma: A Rare Case Report
Testicular neuroendocrine tumor associated with teratoma is a rare disease. Very few cases have been reported in the literature, particularly cases involving visceral metastasis. Teratoma with somatic malignant transformation (SMT) is associated with a worse prognosis compared to teratoma without SM...
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| Format: | Article |
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Karger Publishers
2022-03-01
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| Series: | Case Reports in Oncology |
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| Online Access: | https://www.karger.com/Article/FullText/521998 |
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| author | Jirapat Wonglhow Patrapim Sunpaweravong Chirawadee Sathitruangsak Kanet Kanjanapradit Arunee Dechaphunkul |
| author_facet | Jirapat Wonglhow Patrapim Sunpaweravong Chirawadee Sathitruangsak Kanet Kanjanapradit Arunee Dechaphunkul |
| author_sort | Jirapat Wonglhow |
| collection | DOAJ |
| description | Testicular neuroendocrine tumor associated with teratoma is a rare disease. Very few cases have been reported in the literature, particularly cases involving visceral metastasis. Teratoma with somatic malignant transformation (SMT) is associated with a worse prognosis compared to teratoma without SMT. Previous data have suggested that chemotherapy regimens should be directed toward the transformed histology; however, those suggestions were based on patients with rhabdomyosarcoma, adenocarcinoma, and primitive neuroectodermal subtypes. To the best of our knowledge, only 2 cases with visceral metastasis have been reported, and a better outcome with the bleomycin/etoposide/cisplatin regimen, which responds strongly to germ cell tumors, has been reported in these cases. In contrast, 2 others with lymph node metastasis did not respond to these regimens. Here, we report a case of a patient with testicular neuroendocrine carcinoma associated with teratoma who achieved a good response to chemotherapy. |
| first_indexed | 2024-04-12T14:41:00Z |
| format | Article |
| id | doaj.art-c7c532189e4f47e5a024ff89aaa6e42b |
| institution | Directory Open Access Journal |
| issn | 1662-6575 |
| language | English |
| last_indexed | 2024-04-12T14:41:00Z |
| publishDate | 2022-03-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Oncology |
| spelling | doaj.art-c7c532189e4f47e5a024ff89aaa6e42b2022-12-22T03:28:50ZengKarger PublishersCase Reports in Oncology1662-65752022-03-0115119119810.1159/000521998521998Metastatic Primary Testicular Neuroendocrine Carcinoma Associated with Somatic Malignant Transformation of Teratoma: A Rare Case ReportJirapat Wonglhow0https://orcid.org/0000-0003-1265-7459Patrapim Sunpaweravong1Chirawadee Sathitruangsak2Kanet Kanjanapradit3Arunee Dechaphunkul4https://orcid.org/0000-0002-0593-4385Unit of Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Songkhla, ThailandUnit of Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Songkhla, ThailandUnit of Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Songkhla, ThailandDepartment of Pathology, Faculty of Medicine, Prince of Songkla University, Songkhla, ThailandUnit of Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Songkhla, ThailandTesticular neuroendocrine tumor associated with teratoma is a rare disease. Very few cases have been reported in the literature, particularly cases involving visceral metastasis. Teratoma with somatic malignant transformation (SMT) is associated with a worse prognosis compared to teratoma without SMT. Previous data have suggested that chemotherapy regimens should be directed toward the transformed histology; however, those suggestions were based on patients with rhabdomyosarcoma, adenocarcinoma, and primitive neuroectodermal subtypes. To the best of our knowledge, only 2 cases with visceral metastasis have been reported, and a better outcome with the bleomycin/etoposide/cisplatin regimen, which responds strongly to germ cell tumors, has been reported in these cases. In contrast, 2 others with lymph node metastasis did not respond to these regimens. Here, we report a case of a patient with testicular neuroendocrine carcinoma associated with teratoma who achieved a good response to chemotherapy.https://www.karger.com/Article/FullText/521998testicular neuroendocrine tumortesticular teratomasomatic malignant transformationchemotherapycase report |
| spellingShingle | Jirapat Wonglhow Patrapim Sunpaweravong Chirawadee Sathitruangsak Kanet Kanjanapradit Arunee Dechaphunkul Metastatic Primary Testicular Neuroendocrine Carcinoma Associated with Somatic Malignant Transformation of Teratoma: A Rare Case Report Case Reports in Oncology testicular neuroendocrine tumor testicular teratoma somatic malignant transformation chemotherapy case report |
| title | Metastatic Primary Testicular Neuroendocrine Carcinoma Associated with Somatic Malignant Transformation of Teratoma: A Rare Case Report |
| title_full | Metastatic Primary Testicular Neuroendocrine Carcinoma Associated with Somatic Malignant Transformation of Teratoma: A Rare Case Report |
| title_fullStr | Metastatic Primary Testicular Neuroendocrine Carcinoma Associated with Somatic Malignant Transformation of Teratoma: A Rare Case Report |
| title_full_unstemmed | Metastatic Primary Testicular Neuroendocrine Carcinoma Associated with Somatic Malignant Transformation of Teratoma: A Rare Case Report |
| title_short | Metastatic Primary Testicular Neuroendocrine Carcinoma Associated with Somatic Malignant Transformation of Teratoma: A Rare Case Report |
| title_sort | metastatic primary testicular neuroendocrine carcinoma associated with somatic malignant transformation of teratoma a rare case report |
| topic | testicular neuroendocrine tumor testicular teratoma somatic malignant transformation chemotherapy case report |
| url | https://www.karger.com/Article/FullText/521998 |
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