The double-edged sword role of hydrogen sulfide in hepatocellular carcinoma
With an increasing worldwide prevalence, hepatocellular carcinoma (HCC) is the most common primary malignant tumor of the liver in the world. It is also the primary reason for cancer-related death in the world. The pathogenesis of HCC is complex, such as DNA methylation changes, immune regulatory di...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-10-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2023.1280308/full |
| _version_ | 1797662148592140288 |
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| author | Huijie Zhao Yanting Zhang Yanting Zhang Xiaodi Fu Chaoren Chen Saadullah Khattak Saadullah Khattak Honggang Wang |
| author_facet | Huijie Zhao Yanting Zhang Yanting Zhang Xiaodi Fu Chaoren Chen Saadullah Khattak Saadullah Khattak Honggang Wang |
| author_sort | Huijie Zhao |
| collection | DOAJ |
| description | With an increasing worldwide prevalence, hepatocellular carcinoma (HCC) is the most common primary malignant tumor of the liver in the world. It is also the primary reason for cancer-related death in the world. The pathogenesis of HCC is complex, such as DNA methylation changes, immune regulatory disorders, cell cycle disorders, chromosomal instability, and so on. Although many studies have been conducted on HCC, the molecular mechanisms of HCC are not completely understood. At present, there is no effective treatment for HCC. Hydrogen sulfide (H2S) has long been regarded as a toxic gas with the smell of rotten eggs, but recent studies have shown that it is an important gasotransmitter along with carbon monoxide (CO) and nitric oxide (NO). Increasing evidence indicates that H2S has multiple biological functions, such as anti-inflammation, anti-apoptosis, anti-oxidative stress, and so on. Recently, a lot of evidence has shown that H2S has a “double-edged sword” effect in HCC, but the mechanism is not fully understood. Here, we reviewed the progress on the role and mechanism of H2S in HCC in recent years, hoping to provide a theoretical reference for future related research. |
| first_indexed | 2024-03-11T18:55:56Z |
| format | Article |
| id | doaj.art-c7c57d1db7aa49f2a0abfaa019b1636c |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-03-11T18:55:56Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-c7c57d1db7aa49f2a0abfaa019b1636c2023-10-11T04:58:25ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122023-10-011410.3389/fphar.2023.12803081280308The double-edged sword role of hydrogen sulfide in hepatocellular carcinomaHuijie Zhao0Yanting Zhang1Yanting Zhang2Xiaodi Fu3Chaoren Chen4Saadullah Khattak5Saadullah Khattak6Honggang Wang7Institute of Chronic Disease Risks Assessment, Henan University, Kaifeng, ChinaSchool of Basic Medical Sciences, Henan University, Kaifeng, Henan, ChinaSchool of Clinical Medicine, Henan University, Kaifeng, Henan, ChinaSchool of Basic Medical Sciences, Henan University, Kaifeng, Henan, ChinaSchool of Nursing and Health, Institute of Nursing and Health, Henan University, Kaifeng, Henan, ChinaHenan International Joint Laboratory for Nuclear Protein Regulation, School of Basic Medical Sciences, Henan University, Kaifeng, Henan, ChinaSchool of Life Sciences, Henan University, Kaifeng, ChinaSchool of Basic Medical Sciences, Henan University, Kaifeng, Henan, ChinaWith an increasing worldwide prevalence, hepatocellular carcinoma (HCC) is the most common primary malignant tumor of the liver in the world. It is also the primary reason for cancer-related death in the world. The pathogenesis of HCC is complex, such as DNA methylation changes, immune regulatory disorders, cell cycle disorders, chromosomal instability, and so on. Although many studies have been conducted on HCC, the molecular mechanisms of HCC are not completely understood. At present, there is no effective treatment for HCC. Hydrogen sulfide (H2S) has long been regarded as a toxic gas with the smell of rotten eggs, but recent studies have shown that it is an important gasotransmitter along with carbon monoxide (CO) and nitric oxide (NO). Increasing evidence indicates that H2S has multiple biological functions, such as anti-inflammation, anti-apoptosis, anti-oxidative stress, and so on. Recently, a lot of evidence has shown that H2S has a “double-edged sword” effect in HCC, but the mechanism is not fully understood. Here, we reviewed the progress on the role and mechanism of H2S in HCC in recent years, hoping to provide a theoretical reference for future related research.https://www.frontiersin.org/articles/10.3389/fphar.2023.1280308/fullhydrogen sulfidehepatocellular carcinomaapoptosiscystathione gamma-lyase3-mercaptopyruvate sulfurtransferase |
| spellingShingle | Huijie Zhao Yanting Zhang Yanting Zhang Xiaodi Fu Chaoren Chen Saadullah Khattak Saadullah Khattak Honggang Wang The double-edged sword role of hydrogen sulfide in hepatocellular carcinoma Frontiers in Pharmacology hydrogen sulfide hepatocellular carcinoma apoptosis cystathione gamma-lyase 3-mercaptopyruvate sulfurtransferase |
| title | The double-edged sword role of hydrogen sulfide in hepatocellular carcinoma |
| title_full | The double-edged sword role of hydrogen sulfide in hepatocellular carcinoma |
| title_fullStr | The double-edged sword role of hydrogen sulfide in hepatocellular carcinoma |
| title_full_unstemmed | The double-edged sword role of hydrogen sulfide in hepatocellular carcinoma |
| title_short | The double-edged sword role of hydrogen sulfide in hepatocellular carcinoma |
| title_sort | double edged sword role of hydrogen sulfide in hepatocellular carcinoma |
| topic | hydrogen sulfide hepatocellular carcinoma apoptosis cystathione gamma-lyase 3-mercaptopyruvate sulfurtransferase |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2023.1280308/full |
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