Hydrogels loaded with atenolol drug metal–organic framework showing biological activity
Using the starting reactants of Zn(OAc)2 and 2-mercaptonicotinic acid (H2L), we successfully synthesized a fresh Zn(ii) compound, that is, [Zn3(L)3]n (1), under hydrothermal conditions and then successfully loaded with atenolol. Hualuronic acid/carboxymethyl chitosan hydrogels loaded with atenolol d...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2023-07-01
|
| Series: | Science and Engineering of Composite Materials |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/secm-2022-0216 |
| _version_ | 1797784171298422784 |
|---|---|
| author | Du Juan Fan Limei Fu Jinfeng |
| author_facet | Du Juan Fan Limei Fu Jinfeng |
| author_sort | Du Juan |
| collection | DOAJ |
| description | Using the starting reactants of Zn(OAc)2 and 2-mercaptonicotinic acid (H2L), we successfully synthesized a fresh Zn(ii) compound, that is, [Zn3(L)3]n (1), under hydrothermal conditions and then successfully loaded with atenolol. Hualuronic acid/carboxymethyl chitosan hydrogels loaded with atenolol drug metal–organic framework were prepared based on a chemical synthesis method. The microscopic morphology of the hydrogels was investigated, and scanning electron microscopic results showed that the hydrogels had a highly porous morphology with good penetration between the pores. For the new hydrogels, the enzyme-linked immunosorbent assay detection was conducted, and the production of sVCAM-1 and TNF-a in vascular endothelial cells was determined. Besides, the levels of inflammatory response in the vascular endothelial cells were also determined with the real-time reverse transcriptase polymerase chain reaction assay. |
| first_indexed | 2024-03-13T00:36:10Z |
| format | Article |
| id | doaj.art-c7c5875be0df450a879a2add29a2d48a |
| institution | Directory Open Access Journal |
| issn | 2191-0359 |
| language | English |
| last_indexed | 2024-03-13T00:36:10Z |
| publishDate | 2023-07-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Science and Engineering of Composite Materials |
| spelling | doaj.art-c7c5875be0df450a879a2add29a2d48a2023-07-10T06:04:27ZengDe GruyterScience and Engineering of Composite Materials2191-03592023-07-013011199372110.1515/secm-2022-0216Hydrogels loaded with atenolol drug metal–organic framework showing biological activityDu Juan0Fan Limei1Fu Jinfeng2School of Chemical and Environmental Engineering, Jiaozuo University, Jiaozuo454000, ChinaSchool of Chemical and Environmental Engineering, Jiaozuo University, Jiaozuo454000, ChinaSchool of Chemical and Environmental Engineering, Jiaozuo University, Jiaozuo454000, ChinaUsing the starting reactants of Zn(OAc)2 and 2-mercaptonicotinic acid (H2L), we successfully synthesized a fresh Zn(ii) compound, that is, [Zn3(L)3]n (1), under hydrothermal conditions and then successfully loaded with atenolol. Hualuronic acid/carboxymethyl chitosan hydrogels loaded with atenolol drug metal–organic framework were prepared based on a chemical synthesis method. The microscopic morphology of the hydrogels was investigated, and scanning electron microscopic results showed that the hydrogels had a highly porous morphology with good penetration between the pores. For the new hydrogels, the enzyme-linked immunosorbent assay detection was conducted, and the production of sVCAM-1 and TNF-a in vascular endothelial cells was determined. Besides, the levels of inflammatory response in the vascular endothelial cells were also determined with the real-time reverse transcriptase polymerase chain reaction assay.https://doi.org/10.1515/secm-2022-0216zn(ii) compoundhydrogelsatenolol |
| spellingShingle | Du Juan Fan Limei Fu Jinfeng Hydrogels loaded with atenolol drug metal–organic framework showing biological activity Science and Engineering of Composite Materials zn(ii) compound hydrogels atenolol |
| title | Hydrogels loaded with atenolol drug metal–organic framework showing biological activity |
| title_full | Hydrogels loaded with atenolol drug metal–organic framework showing biological activity |
| title_fullStr | Hydrogels loaded with atenolol drug metal–organic framework showing biological activity |
| title_full_unstemmed | Hydrogels loaded with atenolol drug metal–organic framework showing biological activity |
| title_short | Hydrogels loaded with atenolol drug metal–organic framework showing biological activity |
| title_sort | hydrogels loaded with atenolol drug metal organic framework showing biological activity |
| topic | zn(ii) compound hydrogels atenolol |
| url | https://doi.org/10.1515/secm-2022-0216 |
| work_keys_str_mv | AT dujuan hydrogelsloadedwithatenololdrugmetalorganicframeworkshowingbiologicalactivity AT fanlimei hydrogelsloadedwithatenololdrugmetalorganicframeworkshowingbiologicalactivity AT fujinfeng hydrogelsloadedwithatenololdrugmetalorganicframeworkshowingbiologicalactivity |