Lung function six months after severe COVID-19: Does time, in fact, heal all wounds?
Background: COVID-19 has been associated with persistent symptoms and functional changes, especially in those surviving severe disease. Methods: We conducted a prospective multicenter study in patients with severe COVID-19 to determine respiratory sequelae. Patients were stratified into two groups:...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-05-01
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| Series: | Brazilian Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S141386702200040X |
| _version_ | 1811333791878217728 |
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| author | Daniel Cruz Bretas Arnaldo Santos Leite Eliane Viana Mancuzo Tarciane Aline Prata Bruno Horta Andrade Jacqueline das Graças Ferreira Oliveira Aline Priscila Batista George Luiz Lins Machado-Coelho Valéria Maria Augusto Carolina Coimbra Marinho |
| author_facet | Daniel Cruz Bretas Arnaldo Santos Leite Eliane Viana Mancuzo Tarciane Aline Prata Bruno Horta Andrade Jacqueline das Graças Ferreira Oliveira Aline Priscila Batista George Luiz Lins Machado-Coelho Valéria Maria Augusto Carolina Coimbra Marinho |
| author_sort | Daniel Cruz Bretas |
| collection | DOAJ |
| description | Background: COVID-19 has been associated with persistent symptoms and functional changes, especially in those surviving severe disease. Methods: We conducted a prospective multicenter study in patients with severe COVID-19 to determine respiratory sequelae. Patients were stratified into two groups: ward admission (WA) and intensive care unit (ICU) admission. In each follow-up visit, the patients where inquired about cough and dyspnea, and performed spirometry, lung volumes, carbon monoxide diffusion capacity (DLCO), 6-minute walk test (6MWT), and respiratory muscle strength (MIP and MEP). Results of pulmonary function tests at 45 days and 6 months after hospital admission were compared using paired analysis. Results: 211 patients were included, 112 in WA and 99 in ICU. Dyspnea persisted in 64.7% in the WA and 66.7% in the ICU group after 6 months. Lung function measures showed significant improvement between 45 days and 6 months, both in WA and ICU groups in VC, FVC, FEV1, total lung capacity, and 6MW distance measures. The improvement in the proportions of the altered functional parameters was significant in the ICU group for VC (44.2% 45 d; 20.8% 6 m; p = 0,014), FVC (47.6% 45 d; 28% 6 m; p = 0,003), FEV1 (45.1% 45 d; 28% 6 m; p = 0,044), DLCO (33.8% 45 d; 7.7% 6 m; p < 0,0001). Conclusion: Six months follow-up of patients with the severe forms of COVID-19 showed significant improvement in the lung function measures compared to 45 days post hospital discharge. The difference was more evident in those requiring ICU admission. |
| first_indexed | 2024-04-13T16:58:10Z |
| format | Article |
| id | doaj.art-c7c603335f974e41b66ca70ee9df5dac |
| institution | Directory Open Access Journal |
| issn | 1413-8670 |
| language | English |
| last_indexed | 2024-04-13T16:58:10Z |
| publishDate | 2022-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brazilian Journal of Infectious Diseases |
| spelling | doaj.art-c7c603335f974e41b66ca70ee9df5dac2022-12-22T02:38:45ZengElsevierBrazilian Journal of Infectious Diseases1413-86702022-05-01263102352Lung function six months after severe COVID-19: Does time, in fact, heal all wounds?Daniel Cruz Bretas0Arnaldo Santos Leite1Eliane Viana Mancuzo2Tarciane Aline Prata3Bruno Horta Andrade4Jacqueline das Graças Ferreira Oliveira5Aline Priscila Batista6George Luiz Lins Machado-Coelho7Valéria Maria Augusto8Carolina Coimbra Marinho9Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil; Corresponding author.Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, BrazilHospital Eduardo de Menezes - Fundação Hospitalar de Minas Gerais (FHEMIG), Belo Horizonte, MG, BrazilUniversidade Federal de Ouro Preto (UFOP), Ouro Preto, MG, BrazilUniversidade Federal de Ouro Preto (UFOP), Ouro Preto, MG, BrazilUniversidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, BrazilBackground: COVID-19 has been associated with persistent symptoms and functional changes, especially in those surviving severe disease. Methods: We conducted a prospective multicenter study in patients with severe COVID-19 to determine respiratory sequelae. Patients were stratified into two groups: ward admission (WA) and intensive care unit (ICU) admission. In each follow-up visit, the patients where inquired about cough and dyspnea, and performed spirometry, lung volumes, carbon monoxide diffusion capacity (DLCO), 6-minute walk test (6MWT), and respiratory muscle strength (MIP and MEP). Results of pulmonary function tests at 45 days and 6 months after hospital admission were compared using paired analysis. Results: 211 patients were included, 112 in WA and 99 in ICU. Dyspnea persisted in 64.7% in the WA and 66.7% in the ICU group after 6 months. Lung function measures showed significant improvement between 45 days and 6 months, both in WA and ICU groups in VC, FVC, FEV1, total lung capacity, and 6MW distance measures. The improvement in the proportions of the altered functional parameters was significant in the ICU group for VC (44.2% 45 d; 20.8% 6 m; p = 0,014), FVC (47.6% 45 d; 28% 6 m; p = 0,003), FEV1 (45.1% 45 d; 28% 6 m; p = 0,044), DLCO (33.8% 45 d; 7.7% 6 m; p < 0,0001). Conclusion: Six months follow-up of patients with the severe forms of COVID-19 showed significant improvement in the lung function measures compared to 45 days post hospital discharge. The difference was more evident in those requiring ICU admission.http://www.sciencedirect.com/science/article/pii/S141386702200040XCOVID-19Lung functionFollow-upPost-COVID condition |
| spellingShingle | Daniel Cruz Bretas Arnaldo Santos Leite Eliane Viana Mancuzo Tarciane Aline Prata Bruno Horta Andrade Jacqueline das Graças Ferreira Oliveira Aline Priscila Batista George Luiz Lins Machado-Coelho Valéria Maria Augusto Carolina Coimbra Marinho Lung function six months after severe COVID-19: Does time, in fact, heal all wounds? Brazilian Journal of Infectious Diseases COVID-19 Lung function Follow-up Post-COVID condition |
| title | Lung function six months after severe COVID-19: Does time, in fact, heal all wounds? |
| title_full | Lung function six months after severe COVID-19: Does time, in fact, heal all wounds? |
| title_fullStr | Lung function six months after severe COVID-19: Does time, in fact, heal all wounds? |
| title_full_unstemmed | Lung function six months after severe COVID-19: Does time, in fact, heal all wounds? |
| title_short | Lung function six months after severe COVID-19: Does time, in fact, heal all wounds? |
| title_sort | lung function six months after severe covid 19 does time in fact heal all wounds |
| topic | COVID-19 Lung function Follow-up Post-COVID condition |
| url | http://www.sciencedirect.com/science/article/pii/S141386702200040X |
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