Effects of Lithium on Morphine Tolerance Using Analgesia, Nitrite Determination, Histology and Immunohistochemistry of Forehead Cortex in Adult Male Swiss Mice

Effects of Lithium on Morphine Tolerance Using Analgesia, Nitrite Determination, Histology and Immunohistochemistry of Forehead Cortex in Adult Male Swiss Mice

Background and Objective: Chronic use of opioids leads to analgesic tolerance. Protein kinase C (PKC), adenylyl cyclase (AC), nitric oxide (NO) and glycogen synthase kinase 3 beta (GSK-3β) are involved in morphine tolerance. Lithium activates the phosphatidylinositol 3 kinase (PI3K)/protein kinase B...

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Bibliographic Details
Main Authors: Saman Barzegar, Tayebeh Noori, Mohammad Hosein Farzaei, Mozafar Khazaei, Samira Shirooie
Format: Article
Language:fas
Published: Golestan University of Medical Sciences 2022-09-01
Series:مجله دانشگاه علوم پزشکی گرگان
Subjects:
opioid
pain
morphine
glycogen synthase kinase 3 beta
lithium
Online Access:http://goums.ac.ir/journal/article-1-4088-en.html

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