Association Between Gestational Diabetes Mellitus and the Risks of Type-Specific Cardiovascular Diseases
ObjectiveGestational diabetes mellitus (GDM) has been linked to subsequent overall cardiovascular diseases. However, evidence on the associations of GDM with type-specific cardiovascular diseases is lacking, and findings on the potential impact of type 2 diabetes on the associations are not consiste...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2022.940335/full |
| _version_ | 1817979314535137280 |
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| author | Yuanyuan Mao Yuanyuan Mao Wenbin Hu Bin Xia Bin Xia Li Liu Xia Han Qin Liu |
| author_facet | Yuanyuan Mao Yuanyuan Mao Wenbin Hu Bin Xia Bin Xia Li Liu Xia Han Qin Liu |
| author_sort | Yuanyuan Mao |
| collection | DOAJ |
| description | ObjectiveGestational diabetes mellitus (GDM) has been linked to subsequent overall cardiovascular diseases. However, evidence on the associations of GDM with type-specific cardiovascular diseases is lacking, and findings on the potential impact of type 2 diabetes on the associations are not consistent. This study aimed to explore the associations between GDM and the risks of type-specific cardiovascular diseases.MethodsData were from 12,025 women (≥20 years) who had delivered at least one live birth in the National Health and Nutrition Examination Survey, 2007–2018. GDM history and type-specific cardiovascular diseases including coronary heart disease (CHD), heart failure and stroke were defined by self-report. We also combined our results with those from previously related publications on the associations between GDM and risks of type-specific cardiovascular diseases with a random-effect model.ResultsCompared with women without GDM, the multivariable-adjusted odds ratios (95% confidence intervals) were 1.82 (1.21–2.72) for CHD, 1.43 (0.80–2.53) for heart failure, and 1.19 (0.76–1.86) for stroke among women with a history of GDM. Type 2 diabetes was associated with 43.90, 67.44, and 63.16% of the excess odds of CHD, heart failure and stroke associated with GDM, respectively. Combining results from this study with those from previously related studies yielded odds ratios (95% confidence intervals) of 1.81 (1.60–2.05) for CHD (12 studies, 7,615,322 participants, I2= 72.6%), 1.66 (1.25–2.21) for heart failure (5 studies, 4,491,665 participants, I2= 88.6%), and 1.25 (1.07–1.46) for cerebrovascular disease (9 studies, 6,090,848 participants, I2= 77.8%).ConclusionsGDM showed stronger associations with coronary heart diseases and heart failure than cerebrovascular disease, and the excess risks are attributable, in part, to type 2 diabetes. |
| first_indexed | 2024-04-13T22:41:18Z |
| format | Article |
| id | doaj.art-c7c69dfafc224642b7a4eadf0044d75c |
| institution | Directory Open Access Journal |
| issn | 2296-2565 |
| language | English |
| last_indexed | 2024-04-13T22:41:18Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Public Health |
| spelling | doaj.art-c7c69dfafc224642b7a4eadf0044d75c2022-12-22T02:26:37ZengFrontiers Media S.A.Frontiers in Public Health2296-25652022-07-011010.3389/fpubh.2022.940335940335Association Between Gestational Diabetes Mellitus and the Risks of Type-Specific Cardiovascular DiseasesYuanyuan Mao0Yuanyuan Mao1Wenbin Hu2Bin Xia3Bin Xia4Li Liu5Xia Han6Qin Liu7Department of Obstetrics and Gynecology, Suzhou Medical College of Soochow University, Suzhou, ChinaDepartment of Obstetrics and Gynecology, The First People's Hospital of Kunshan Affiliated With Jiangsu University, Suzhou, ChinaDepartment of Chronic and Noncommunicable Disease Control and Preventions, The Kunshan Center for Disease Control and Prevention, Suzhou, ChinaDepartment of Obstetrics and Gynecology, Suzhou Medical College of Soochow University, Suzhou, ChinaDepartment of Obstetrics and Gynecology, The First People's Hospital of Kunshan Affiliated With Jiangsu University, Suzhou, ChinaDepartment of Obstetrics and Gynecology, The First People's Hospital of Kunshan Affiliated With Jiangsu University, Suzhou, ChinaDepartment of Administration, Maternal and Child Health Institution, Kunshan, ChinaDepartment of Obstetrics and Gynecology, The First People's Hospital of Kunshan Affiliated With Jiangsu University, Suzhou, ChinaObjectiveGestational diabetes mellitus (GDM) has been linked to subsequent overall cardiovascular diseases. However, evidence on the associations of GDM with type-specific cardiovascular diseases is lacking, and findings on the potential impact of type 2 diabetes on the associations are not consistent. This study aimed to explore the associations between GDM and the risks of type-specific cardiovascular diseases.MethodsData were from 12,025 women (≥20 years) who had delivered at least one live birth in the National Health and Nutrition Examination Survey, 2007–2018. GDM history and type-specific cardiovascular diseases including coronary heart disease (CHD), heart failure and stroke were defined by self-report. We also combined our results with those from previously related publications on the associations between GDM and risks of type-specific cardiovascular diseases with a random-effect model.ResultsCompared with women without GDM, the multivariable-adjusted odds ratios (95% confidence intervals) were 1.82 (1.21–2.72) for CHD, 1.43 (0.80–2.53) for heart failure, and 1.19 (0.76–1.86) for stroke among women with a history of GDM. Type 2 diabetes was associated with 43.90, 67.44, and 63.16% of the excess odds of CHD, heart failure and stroke associated with GDM, respectively. Combining results from this study with those from previously related studies yielded odds ratios (95% confidence intervals) of 1.81 (1.60–2.05) for CHD (12 studies, 7,615,322 participants, I2= 72.6%), 1.66 (1.25–2.21) for heart failure (5 studies, 4,491,665 participants, I2= 88.6%), and 1.25 (1.07–1.46) for cerebrovascular disease (9 studies, 6,090,848 participants, I2= 77.8%).ConclusionsGDM showed stronger associations with coronary heart diseases and heart failure than cerebrovascular disease, and the excess risks are attributable, in part, to type 2 diabetes.https://www.frontiersin.org/articles/10.3389/fpubh.2022.940335/fullgestational diabetes mellitustype 2 diabetescoronary heart diseaseheart failurecerebrovascular disease |
| spellingShingle | Yuanyuan Mao Yuanyuan Mao Wenbin Hu Bin Xia Bin Xia Li Liu Xia Han Qin Liu Association Between Gestational Diabetes Mellitus and the Risks of Type-Specific Cardiovascular Diseases Frontiers in Public Health gestational diabetes mellitus type 2 diabetes coronary heart disease heart failure cerebrovascular disease |
| title | Association Between Gestational Diabetes Mellitus and the Risks of Type-Specific Cardiovascular Diseases |
| title_full | Association Between Gestational Diabetes Mellitus and the Risks of Type-Specific Cardiovascular Diseases |
| title_fullStr | Association Between Gestational Diabetes Mellitus and the Risks of Type-Specific Cardiovascular Diseases |
| title_full_unstemmed | Association Between Gestational Diabetes Mellitus and the Risks of Type-Specific Cardiovascular Diseases |
| title_short | Association Between Gestational Diabetes Mellitus and the Risks of Type-Specific Cardiovascular Diseases |
| title_sort | association between gestational diabetes mellitus and the risks of type specific cardiovascular diseases |
| topic | gestational diabetes mellitus type 2 diabetes coronary heart disease heart failure cerebrovascular disease |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2022.940335/full |
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