Tunable deterministic lateral displacement of particles flowing through thermo-responsive hydrogel micropillar arrays
Abstract Deterministic lateral displacement (DLD) is a promising technology that allows for the continuous and the size-based separation of suspended particles at a high resolution through periodically arrayed micropillars. In conventional DLD, the critical diameter (D c), which determines the migra...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-03-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-32233-z |
| _version_ | 1797853877866856448 |
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| author | Naotomo Tottori Takasi Nisisako |
| author_facet | Naotomo Tottori Takasi Nisisako |
| author_sort | Naotomo Tottori |
| collection | DOAJ |
| description | Abstract Deterministic lateral displacement (DLD) is a promising technology that allows for the continuous and the size-based separation of suspended particles at a high resolution through periodically arrayed micropillars. In conventional DLD, the critical diameter (D c), which determines the migration mode of a particle of a particular size, is fixed by the device geometry. Here, we propose a novel DLD that uses the pillars of a thermo-responsive hydrogel, poly(N-isopropylacrylamide) (PNIPAM) to flexibly tune the D c value. Upon heating and cooling, the PNIPAM pillars in the aqueous solution shrink and swell because of their hydrophobic-hydrophilic phase transitions as the temperature varies. Using the PNIPAM pillars confined in a poly(dimethylsiloxane) microchannel, we demonstrate continuous switching of particle (7-μm beads) trajectories (displacement or zigzag mode) by adjusting the D c through temperature control of the device on a Peltier element. Further, we perform on/off operation of the particle separation (7-μm and 2-μm beads) by adjusting the D c values. |
| first_indexed | 2024-04-09T19:57:55Z |
| format | Article |
| id | doaj.art-c7c7290a33744e7e81fabbf1a1f40bf5 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-09T19:57:55Z |
| publishDate | 2023-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-c7c7290a33744e7e81fabbf1a1f40bf52023-04-03T05:23:07ZengNature PortfolioScientific Reports2045-23222023-03-0113111010.1038/s41598-023-32233-zTunable deterministic lateral displacement of particles flowing through thermo-responsive hydrogel micropillar arraysNaotomo Tottori0Takasi Nisisako1Department of Mechanical Engineering, School of Engineering, Tokyo Institute of TechnologyLaboratory for Future Interdisciplinary Research of Science and Technology (FIRST), Institute of Innovative Research, Tokyo Institute of TechnologyAbstract Deterministic lateral displacement (DLD) is a promising technology that allows for the continuous and the size-based separation of suspended particles at a high resolution through periodically arrayed micropillars. In conventional DLD, the critical diameter (D c), which determines the migration mode of a particle of a particular size, is fixed by the device geometry. Here, we propose a novel DLD that uses the pillars of a thermo-responsive hydrogel, poly(N-isopropylacrylamide) (PNIPAM) to flexibly tune the D c value. Upon heating and cooling, the PNIPAM pillars in the aqueous solution shrink and swell because of their hydrophobic-hydrophilic phase transitions as the temperature varies. Using the PNIPAM pillars confined in a poly(dimethylsiloxane) microchannel, we demonstrate continuous switching of particle (7-μm beads) trajectories (displacement or zigzag mode) by adjusting the D c through temperature control of the device on a Peltier element. Further, we perform on/off operation of the particle separation (7-μm and 2-μm beads) by adjusting the D c values.https://doi.org/10.1038/s41598-023-32233-z |
| spellingShingle | Naotomo Tottori Takasi Nisisako Tunable deterministic lateral displacement of particles flowing through thermo-responsive hydrogel micropillar arrays Scientific Reports |
| title | Tunable deterministic lateral displacement of particles flowing through thermo-responsive hydrogel micropillar arrays |
| title_full | Tunable deterministic lateral displacement of particles flowing through thermo-responsive hydrogel micropillar arrays |
| title_fullStr | Tunable deterministic lateral displacement of particles flowing through thermo-responsive hydrogel micropillar arrays |
| title_full_unstemmed | Tunable deterministic lateral displacement of particles flowing through thermo-responsive hydrogel micropillar arrays |
| title_short | Tunable deterministic lateral displacement of particles flowing through thermo-responsive hydrogel micropillar arrays |
| title_sort | tunable deterministic lateral displacement of particles flowing through thermo responsive hydrogel micropillar arrays |
| url | https://doi.org/10.1038/s41598-023-32233-z |
| work_keys_str_mv | AT naotomotottori tunabledeterministiclateraldisplacementofparticlesflowingthroughthermoresponsivehydrogelmicropillararrays AT takasinisisako tunabledeterministiclateraldisplacementofparticlesflowingthroughthermoresponsivehydrogelmicropillararrays |