Safety and Efficacy upon Infection in Sheep with Rift Valley Fever Virus ZH548-rA2, a Triple Mutant Rescued Virus

Safety and Efficacy upon Infection in Sheep with Rift Valley Fever Virus ZH548-rA2, a Triple Mutant Rescued Virus

The introduction of three single nucleotide mutations into the genome of the virulent RVFV ZH548 strain allows for the rescue of a fully attenuated virus in mice (ZH548-rA2). These mutations are located in the viral genes encoding the RdRp and the non-structural protein NSs. This paper shows the res...

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Bibliographic Details
Main Authors: Sandra Moreno, Gema Lorenzo, Álvaro López-Valiñas, Nuria de la Losa, Celia Alonso, Elena Charro, José I. Núñez, Pedro J. Sánchez-Cordón, Belén Borrego, Alejandro Brun
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Viruses
Subjects:
Rift Valley fever virus
attenuating mutations
vaccine efficacy
sheep pathology
Online Access:https://www.mdpi.com/1999-4915/16/1/87

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