Comparison of Efficacy and Safety of Different Doses of Dexmedetomidine for Epidural Labor Analgesia
Objective. To explore the efficacy and safety of different doses of dexmedetomidine (DEX) for epidural labor analgesia (ELA). Methods. From June 2021 to June 2022, 147 parturients who underwent ELA in our hospital were selected and divided into low- (0.5 μg/kg DEX), medium- (0.75 μg/kg DEX), and hig...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Hindawi Limited
2023-01-01
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| Series: | Emergency Medicine International |
| Online Access: | http://dx.doi.org/10.1155/2023/2358888 |
| _version_ | 1797848266677682176 |
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| author | Liang Ge Peng Zhang Lingguo Kong Wei Wang Qian Tong Quanlong Fan Xudong Han |
| author_facet | Liang Ge Peng Zhang Lingguo Kong Wei Wang Qian Tong Quanlong Fan Xudong Han |
| author_sort | Liang Ge |
| collection | DOAJ |
| description | Objective. To explore the efficacy and safety of different doses of dexmedetomidine (DEX) for epidural labor analgesia (ELA). Methods. From June 2021 to June 2022, 147 parturients who underwent ELA in our hospital were selected and divided into low- (0.5 μg/kg DEX), medium- (0.75 μg/kg DEX), and high-dose (1.0 μg/kg DEX) groups (n = 49 for each) according to the random number table method. The analgesic effect was assessed using the Ramsay sedation score and Visual Analogue Scale (VAS), and the labor duration, mean arterial pressure (MAP), and heart rate (HR) before and after analgesia, vaginal bleeding within 2 h postpartum, and delivery outcomes (the cesarean section conversion rate and the neonatal Apgar score) were statistically analyzed. Furthermore, the incidence of adverse reactions was calculated, and maternal satisfaction with delivery was investigated. Results. After analgesia, the the Ramsay and labor duration were higher in the high-dose group than those in the low- and medium-dose groups, and the VAS scores was lowerin the high-dose group than those in the low- and medium-dose groupsP<0.05, while no difference was identified among the three groups in terms of the cesarean section conversion rate and the neonatal Apgar score P>0.05. The high-dose group had the greatest fluctuations in MAP and HR levels before and after analgesia than the other two groups, with a higher incidence of adverse reactions P<0.05. Finally, the survey of delivery satisfaction showed no significant difference in delivery satisfaction among the three groups P>0.05. Conclusion. DEX has excellent performance in ELA, which can effectively relieve the pain of puerperae and shorten the labor process. Among them, low-dose DEX has higher safety and is recommended as the first choice. Trial Registrations. This trial is registered with ML2021073. |
| first_indexed | 2024-04-09T18:25:52Z |
| format | Article |
| id | doaj.art-c7c855a1ecbd45a8b21759a58565c3ea |
| institution | Directory Open Access Journal |
| issn | 2090-2859 |
| language | English |
| last_indexed | 2024-04-09T18:25:52Z |
| publishDate | 2023-01-01 |
| publisher | Hindawi Limited |
| record_format | Article |
| series | Emergency Medicine International |
| spelling | doaj.art-c7c855a1ecbd45a8b21759a58565c3ea2023-04-12T00:00:07ZengHindawi LimitedEmergency Medicine International2090-28592023-01-01202310.1155/2023/2358888Comparison of Efficacy and Safety of Different Doses of Dexmedetomidine for Epidural Labor AnalgesiaLiang Ge0Peng Zhang1Lingguo Kong2Wei Wang3Qian Tong4Quanlong Fan5Xudong Han6Department of AnesthesiologyDepartment of AnesthesiologyDepartment of AnesthesiologyThe Reproductive Medicine Special Hospital of the 1st Hospital of Lanzhou UniversityDepartment of AnesthesiologyDepartment of AnesthesiologyDepartment of AnesthesiologyObjective. To explore the efficacy and safety of different doses of dexmedetomidine (DEX) for epidural labor analgesia (ELA). Methods. From June 2021 to June 2022, 147 parturients who underwent ELA in our hospital were selected and divided into low- (0.5 μg/kg DEX), medium- (0.75 μg/kg DEX), and high-dose (1.0 μg/kg DEX) groups (n = 49 for each) according to the random number table method. The analgesic effect was assessed using the Ramsay sedation score and Visual Analogue Scale (VAS), and the labor duration, mean arterial pressure (MAP), and heart rate (HR) before and after analgesia, vaginal bleeding within 2 h postpartum, and delivery outcomes (the cesarean section conversion rate and the neonatal Apgar score) were statistically analyzed. Furthermore, the incidence of adverse reactions was calculated, and maternal satisfaction with delivery was investigated. Results. After analgesia, the the Ramsay and labor duration were higher in the high-dose group than those in the low- and medium-dose groups, and the VAS scores was lowerin the high-dose group than those in the low- and medium-dose groupsP<0.05, while no difference was identified among the three groups in terms of the cesarean section conversion rate and the neonatal Apgar score P>0.05. The high-dose group had the greatest fluctuations in MAP and HR levels before and after analgesia than the other two groups, with a higher incidence of adverse reactions P<0.05. Finally, the survey of delivery satisfaction showed no significant difference in delivery satisfaction among the three groups P>0.05. Conclusion. DEX has excellent performance in ELA, which can effectively relieve the pain of puerperae and shorten the labor process. Among them, low-dose DEX has higher safety and is recommended as the first choice. Trial Registrations. This trial is registered with ML2021073.http://dx.doi.org/10.1155/2023/2358888 |
| spellingShingle | Liang Ge Peng Zhang Lingguo Kong Wei Wang Qian Tong Quanlong Fan Xudong Han Comparison of Efficacy and Safety of Different Doses of Dexmedetomidine for Epidural Labor Analgesia Emergency Medicine International |
| title | Comparison of Efficacy and Safety of Different Doses of Dexmedetomidine for Epidural Labor Analgesia |
| title_full | Comparison of Efficacy and Safety of Different Doses of Dexmedetomidine for Epidural Labor Analgesia |
| title_fullStr | Comparison of Efficacy and Safety of Different Doses of Dexmedetomidine for Epidural Labor Analgesia |
| title_full_unstemmed | Comparison of Efficacy and Safety of Different Doses of Dexmedetomidine for Epidural Labor Analgesia |
| title_short | Comparison of Efficacy and Safety of Different Doses of Dexmedetomidine for Epidural Labor Analgesia |
| title_sort | comparison of efficacy and safety of different doses of dexmedetomidine for epidural labor analgesia |
| url | http://dx.doi.org/10.1155/2023/2358888 |
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