Association between interleukin 6 -174 G/C promoter gene polymorphism and runners' responses to the dietary ingestion of antioxidant supplementation based on pequi (Caryocar brasiliense Camb.) oil: a before-after study
Abstract Exercise is a double-edged sword: when practiced in moderation, it increases the expression of antioxidant enzymes, but when practiced strenuously it causes oxidative stress and cell damage. In this context, polymorphisms in the interleukin (IL)-6 gene should be investigated better because...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Genética
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| Series: | Genetics and Molecular Biology |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572016005014101&lng=en&tlng=en |
| _version_ | 1818841001962242048 |
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| author | Ana Luisa Miranda-Vilela Ieler Ferreira Ribeiro Cesar Koppe Grisolia |
| author_facet | Ana Luisa Miranda-Vilela Ieler Ferreira Ribeiro Cesar Koppe Grisolia |
| author_sort | Ana Luisa Miranda-Vilela |
| collection | DOAJ |
| description | Abstract Exercise is a double-edged sword: when practiced in moderation, it increases the expression of antioxidant enzymes, but when practiced strenuously it causes oxidative stress and cell damage. In this context, polymorphisms in the interleukin (IL)-6 gene should be investigated better because they can influence performance, at least in exercise that generates oxidative stress and leads to muscular injuries with consequent inflammation. In this work, we investigated the influence of IL-6 –174 G/C polymorphism on tissue damage and inflammation markers, lipid peroxidation, hemogram and lipid profile of runners before and after ingestion of 400 mg of pequi oil in capsules supplied daily for 14 consecutive days. The IL-6 genotypes were associated with significant differences in lipid peroxidation, with the CC mutant having lower values. There were also significant differences among these genotypes in the response to supplementation with pequi oil, exercise-induced damage and C-reactive protein (CRP) levels. The best protection against damage was observed with the heterozygous genotype. Although the CC genotype showed an increase in CRP levels after supplementation, the lack of a positive correlation between triglycerides and high-sensitivity CRP in this mutant genotype after supplementation indicated a protective effect of pequi. These findings deserve further investigation, particularly with regard to the quantification of circulating IL-6 concentrations. |
| first_indexed | 2024-12-19T04:19:09Z |
| format | Article |
| id | doaj.art-c7c8ca78271a4d4788c0171b4f756226 |
| institution | Directory Open Access Journal |
| issn | 1678-4685 |
| language | English |
| last_indexed | 2024-12-19T04:19:09Z |
| publisher | Sociedade Brasileira de Genética |
| record_format | Article |
| series | Genetics and Molecular Biology |
| spelling | doaj.art-c7c8ca78271a4d4788c0171b4f7562262022-12-21T20:36:13ZengSociedade Brasileira de GenéticaGenetics and Molecular Biology1678-4685010.1590/1678-4685-GMB-2015-0299S1415-47572016005014101Association between interleukin 6 -174 G/C promoter gene polymorphism and runners' responses to the dietary ingestion of antioxidant supplementation based on pequi (Caryocar brasiliense Camb.) oil: a before-after studyAna Luisa Miranda-VilelaIeler Ferreira RibeiroCesar Koppe GrisoliaAbstract Exercise is a double-edged sword: when practiced in moderation, it increases the expression of antioxidant enzymes, but when practiced strenuously it causes oxidative stress and cell damage. In this context, polymorphisms in the interleukin (IL)-6 gene should be investigated better because they can influence performance, at least in exercise that generates oxidative stress and leads to muscular injuries with consequent inflammation. In this work, we investigated the influence of IL-6 –174 G/C polymorphism on tissue damage and inflammation markers, lipid peroxidation, hemogram and lipid profile of runners before and after ingestion of 400 mg of pequi oil in capsules supplied daily for 14 consecutive days. The IL-6 genotypes were associated with significant differences in lipid peroxidation, with the CC mutant having lower values. There were also significant differences among these genotypes in the response to supplementation with pequi oil, exercise-induced damage and C-reactive protein (CRP) levels. The best protection against damage was observed with the heterozygous genotype. Although the CC genotype showed an increase in CRP levels after supplementation, the lack of a positive correlation between triglycerides and high-sensitivity CRP in this mutant genotype after supplementation indicated a protective effect of pequi. These findings deserve further investigation, particularly with regard to the quantification of circulating IL-6 concentrations.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572016005014101&lng=en&tlng=enantioxidant supplementationexercise-induced oxidative damageinflammatory markersnutrigeneticsnutrigenomics |
| spellingShingle | Ana Luisa Miranda-Vilela Ieler Ferreira Ribeiro Cesar Koppe Grisolia Association between interleukin 6 -174 G/C promoter gene polymorphism and runners' responses to the dietary ingestion of antioxidant supplementation based on pequi (Caryocar brasiliense Camb.) oil: a before-after study Genetics and Molecular Biology antioxidant supplementation exercise-induced oxidative damage inflammatory markers nutrigenetics nutrigenomics |
| title | Association between interleukin 6 -174 G/C promoter gene polymorphism and runners' responses to the dietary ingestion of antioxidant supplementation based on pequi (Caryocar brasiliense Camb.) oil: a before-after study |
| title_full | Association between interleukin 6 -174 G/C promoter gene polymorphism and runners' responses to the dietary ingestion of antioxidant supplementation based on pequi (Caryocar brasiliense Camb.) oil: a before-after study |
| title_fullStr | Association between interleukin 6 -174 G/C promoter gene polymorphism and runners' responses to the dietary ingestion of antioxidant supplementation based on pequi (Caryocar brasiliense Camb.) oil: a before-after study |
| title_full_unstemmed | Association between interleukin 6 -174 G/C promoter gene polymorphism and runners' responses to the dietary ingestion of antioxidant supplementation based on pequi (Caryocar brasiliense Camb.) oil: a before-after study |
| title_short | Association between interleukin 6 -174 G/C promoter gene polymorphism and runners' responses to the dietary ingestion of antioxidant supplementation based on pequi (Caryocar brasiliense Camb.) oil: a before-after study |
| title_sort | association between interleukin 6 174 g c promoter gene polymorphism and runners responses to the dietary ingestion of antioxidant supplementation based on pequi caryocar brasiliense camb oil a before after study |
| topic | antioxidant supplementation exercise-induced oxidative damage inflammatory markers nutrigenetics nutrigenomics |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572016005014101&lng=en&tlng=en |
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