Oxidative stress-related patterns determination for establishment of prognostic models, and characteristics of tumor microenvironment infiltration
Oxidative stress-mediated excessive accumulation of ROS in the body destroys cell homeostasis and participates in various diseases. However, the relationship between oxidative stress-related genes (ORGs) and tumor microenvironment (TME) in gastric cancer remains poorly understood. For improving the...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Surgery |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fsurg.2022.1013794/full |
| _version_ | 1811256116744552448 |
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| author | Zihao Bai Yihua Bai Changzhong Fang Wenliang Chen |
| author_facet | Zihao Bai Yihua Bai Changzhong Fang Wenliang Chen |
| author_sort | Zihao Bai |
| collection | DOAJ |
| description | Oxidative stress-mediated excessive accumulation of ROS in the body destroys cell homeostasis and participates in various diseases. However, the relationship between oxidative stress-related genes (ORGs) and tumor microenvironment (TME) in gastric cancer remains poorly understood. For improving the treatment strategy of GC, it is necessary to explore the relationship among them. We describe the changes of ORGs in 732 gastric cancer samples from two data sets. The two different molecular subtypes revealed that the changes of ORGs were associated with clinical features, prognosis, and TME. Subsequently, the OE_score was related to RFS, as confirmed by the correlation between OE_score and TME, TMB, MSI, immunotherapy, stem cell analysis, chemotherapeutic drugs, etc. OE_score can be used as an independent predictive marker for the treatment and prognosis of gastric cancer. Further, a Norman diagram was established to improve clinical practicability. Our research showed a potential role of ORGs in clinical features, prognosis, and tumor microenvironment of gastric cancer. Our research findings broaden the understanding of gastric cancer ORGs as a potential target for individualized treatment of gastric cancer and a new direction to evaluate the prognosis. |
| first_indexed | 2024-04-12T17:35:11Z |
| format | Article |
| id | doaj.art-c7c8fbbe6444497bbbe79610b803d213 |
| institution | Directory Open Access Journal |
| issn | 2296-875X |
| language | English |
| last_indexed | 2024-04-12T17:35:11Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Surgery |
| spelling | doaj.art-c7c8fbbe6444497bbbe79610b803d2132022-12-22T03:23:00ZengFrontiers Media S.A.Frontiers in Surgery2296-875X2022-11-01910.3389/fsurg.2022.10137941013794Oxidative stress-related patterns determination for establishment of prognostic models, and characteristics of tumor microenvironment infiltrationZihao Bai0Yihua Bai1Changzhong Fang2Wenliang Chen3Graduate Department, Shanxi Medical University, Taiyuan, ChinaGraduate Department, Shanxi Medical University, Taiyuan, ChinaGraduate Department, Shanxi Medical University, Taiyuan, ChinaDepartment of General Surgery, The 2nd Affiliated Hospital of Shanxi Medical University, Taiyuan, ChinaOxidative stress-mediated excessive accumulation of ROS in the body destroys cell homeostasis and participates in various diseases. However, the relationship between oxidative stress-related genes (ORGs) and tumor microenvironment (TME) in gastric cancer remains poorly understood. For improving the treatment strategy of GC, it is necessary to explore the relationship among them. We describe the changes of ORGs in 732 gastric cancer samples from two data sets. The two different molecular subtypes revealed that the changes of ORGs were associated with clinical features, prognosis, and TME. Subsequently, the OE_score was related to RFS, as confirmed by the correlation between OE_score and TME, TMB, MSI, immunotherapy, stem cell analysis, chemotherapeutic drugs, etc. OE_score can be used as an independent predictive marker for the treatment and prognosis of gastric cancer. Further, a Norman diagram was established to improve clinical practicability. Our research showed a potential role of ORGs in clinical features, prognosis, and tumor microenvironment of gastric cancer. Our research findings broaden the understanding of gastric cancer ORGs as a potential target for individualized treatment of gastric cancer and a new direction to evaluate the prognosis.https://www.frontiersin.org/articles/10.3389/fsurg.2022.1013794/fullgastric canceroxidative stresstumor microenvironmentmicrosatellite instabilityprognosis |
| spellingShingle | Zihao Bai Yihua Bai Changzhong Fang Wenliang Chen Oxidative stress-related patterns determination for establishment of prognostic models, and characteristics of tumor microenvironment infiltration Frontiers in Surgery gastric cancer oxidative stress tumor microenvironment microsatellite instability prognosis |
| title | Oxidative stress-related patterns determination for establishment of prognostic models, and characteristics of tumor microenvironment infiltration |
| title_full | Oxidative stress-related patterns determination for establishment of prognostic models, and characteristics of tumor microenvironment infiltration |
| title_fullStr | Oxidative stress-related patterns determination for establishment of prognostic models, and characteristics of tumor microenvironment infiltration |
| title_full_unstemmed | Oxidative stress-related patterns determination for establishment of prognostic models, and characteristics of tumor microenvironment infiltration |
| title_short | Oxidative stress-related patterns determination for establishment of prognostic models, and characteristics of tumor microenvironment infiltration |
| title_sort | oxidative stress related patterns determination for establishment of prognostic models and characteristics of tumor microenvironment infiltration |
| topic | gastric cancer oxidative stress tumor microenvironment microsatellite instability prognosis |
| url | https://www.frontiersin.org/articles/10.3389/fsurg.2022.1013794/full |
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