Impaired Emotional Mirroring in Parkinson’s Disease—A Study on Brain Activation during Processing of Facial Expressions
BackgroundAffective dysfunctions are common in patients with Parkinson’s disease, but the underlying neurobiological deviations have rarely been examined. Parkinson’s disease is characterized by a loss of dopamine neurons in the substantia nigra resulting in impairment of motor and non-motor basal g...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-12-01
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| Series: | Frontiers in Neurology |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fneur.2017.00682/full |
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| author | Anna Pohl Anna Pohl Silke Anders Hong Chen Harshal Jayeshkumar Patel Harshal Jayeshkumar Patel Julia Heller Julia Heller Kathrin Reetz Kathrin Reetz Klaus Mathiak Klaus Mathiak Ferdinand Binkofski Ferdinand Binkofski Ferdinand Binkofski |
| author_facet | Anna Pohl Anna Pohl Silke Anders Hong Chen Harshal Jayeshkumar Patel Harshal Jayeshkumar Patel Julia Heller Julia Heller Kathrin Reetz Kathrin Reetz Klaus Mathiak Klaus Mathiak Ferdinand Binkofski Ferdinand Binkofski Ferdinand Binkofski |
| author_sort | Anna Pohl |
| collection | DOAJ |
| description | BackgroundAffective dysfunctions are common in patients with Parkinson’s disease, but the underlying neurobiological deviations have rarely been examined. Parkinson’s disease is characterized by a loss of dopamine neurons in the substantia nigra resulting in impairment of motor and non-motor basal ganglia-cortical loops. Concerning emotional deficits, some studies provide evidence for altered brain processing in limbic- and lateral-orbitofrontal gating loops. In a second line of evidence, human premotor and inferior parietal homologs of mirror neuron areas were involved in processing and understanding of emotional facial expressions. We examined deviations in brain activation during processing of facial expressions in patients and related these to emotion recognition accuracy.Methods13 patients and 13 healthy controls underwent an emotion recognition task and a functional magnetic resonance imaging (fMRI) measurement. In the Emotion Hexagon test, participants were presented with blends of two emotions and had to indicate which emotion best described the presented picture. Blended pictures with three levels of difficulty were included. During fMRI scanning, participants observed video clips depicting emotional, non-emotional, and neutral facial expressions or were asked to produce these facial expressions themselves.ResultsPatients performed slightly worse in the emotion recognition task, but only when judging the most ambiguous facial expressions. Both groups activated inferior frontal and anterior inferior parietal homologs of mirror neuron areas during observation and execution of the emotional facial expressions. During observation, responses in the pars opercularis of the right inferior frontal gyrus, in the bilateral inferior parietal lobule and in the bilateral supplementary motor cortex were decreased in patients. Furthermore, in patients, activation of the right anterior inferior parietal lobule was positively related to accuracy in the emotion recognition task.ConclusionOur data provide evidence for a contribution of human homologs of monkey mirror areas to the emotion recognition deficit in Parkinson’s disease. |
| first_indexed | 2024-12-12T19:17:19Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-12T19:17:19Z |
| publishDate | 2017-12-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neurology |
| spelling | doaj.art-c7c92d322f484921ad4eeeb103c7412d2022-12-22T00:14:42ZengFrontiers Media S.A.Frontiers in Neurology1664-22952017-12-01810.3389/fneur.2017.00682313015Impaired Emotional Mirroring in Parkinson’s Disease—A Study on Brain Activation during Processing of Facial ExpressionsAnna Pohl0Anna Pohl1Silke Anders2Hong Chen3Harshal Jayeshkumar Patel4Harshal Jayeshkumar Patel5Julia Heller6Julia Heller7Kathrin Reetz8Kathrin Reetz9Klaus Mathiak10Klaus Mathiak11Ferdinand Binkofski12Ferdinand Binkofski13Ferdinand Binkofski14Department of Psychology, University of Cologne, Cologne, GermanyDivision of Clinical Cognitive Sciences, RWTH Aachen University, Aachen, GermanyDepartment of Neurology, University of Lübeck, Lübeck, GermanyDivision of Clinical Cognitive Sciences, RWTH Aachen University, Aachen, GermanyDivision of Clinical Cognitive Sciences, RWTH Aachen University, Aachen, GermanyInstitute of Neuroscience and Medicine (INM-4), Research Center Jülich GmbH, Jülich, GermanyDepartment of Neurology, RWTH Aachen University, Aachen, GermanyJülich Aachen Research Alliance (JARA), Translational Brain Medicine, Aachen, GermanyDepartment of Neurology, RWTH Aachen University, Aachen, GermanyJülich Aachen Research Alliance (JARA), Translational Brain Medicine, Aachen, GermanyJülich Aachen Research Alliance (JARA), Translational Brain Medicine, Aachen, GermanyDepartment of Psychiatry, Psychotherapy, and Psychosomatics, RWTH Aachen University, Aachen, GermanyDivision of Clinical Cognitive Sciences, RWTH Aachen University, Aachen, GermanyInstitute of Neuroscience and Medicine (INM-4), Research Center Jülich GmbH, Jülich, GermanyJülich Aachen Research Alliance (JARA), Translational Brain Medicine, Aachen, GermanyBackgroundAffective dysfunctions are common in patients with Parkinson’s disease, but the underlying neurobiological deviations have rarely been examined. Parkinson’s disease is characterized by a loss of dopamine neurons in the substantia nigra resulting in impairment of motor and non-motor basal ganglia-cortical loops. Concerning emotional deficits, some studies provide evidence for altered brain processing in limbic- and lateral-orbitofrontal gating loops. In a second line of evidence, human premotor and inferior parietal homologs of mirror neuron areas were involved in processing and understanding of emotional facial expressions. We examined deviations in brain activation during processing of facial expressions in patients and related these to emotion recognition accuracy.Methods13 patients and 13 healthy controls underwent an emotion recognition task and a functional magnetic resonance imaging (fMRI) measurement. In the Emotion Hexagon test, participants were presented with blends of two emotions and had to indicate which emotion best described the presented picture. Blended pictures with three levels of difficulty were included. During fMRI scanning, participants observed video clips depicting emotional, non-emotional, and neutral facial expressions or were asked to produce these facial expressions themselves.ResultsPatients performed slightly worse in the emotion recognition task, but only when judging the most ambiguous facial expressions. Both groups activated inferior frontal and anterior inferior parietal homologs of mirror neuron areas during observation and execution of the emotional facial expressions. During observation, responses in the pars opercularis of the right inferior frontal gyrus, in the bilateral inferior parietal lobule and in the bilateral supplementary motor cortex were decreased in patients. Furthermore, in patients, activation of the right anterior inferior parietal lobule was positively related to accuracy in the emotion recognition task.ConclusionOur data provide evidence for a contribution of human homologs of monkey mirror areas to the emotion recognition deficit in Parkinson’s disease.http://journal.frontiersin.org/article/10.3389/fneur.2017.00682/fullneurodegenerationmirror neuronsemotionfunctional MRIfacial emotionsParkinson’s disease |
| spellingShingle | Anna Pohl Anna Pohl Silke Anders Hong Chen Harshal Jayeshkumar Patel Harshal Jayeshkumar Patel Julia Heller Julia Heller Kathrin Reetz Kathrin Reetz Klaus Mathiak Klaus Mathiak Ferdinand Binkofski Ferdinand Binkofski Ferdinand Binkofski Impaired Emotional Mirroring in Parkinson’s Disease—A Study on Brain Activation during Processing of Facial Expressions Frontiers in Neurology neurodegeneration mirror neurons emotion functional MRI facial emotions Parkinson’s disease |
| title | Impaired Emotional Mirroring in Parkinson’s Disease—A Study on Brain Activation during Processing of Facial Expressions |
| title_full | Impaired Emotional Mirroring in Parkinson’s Disease—A Study on Brain Activation during Processing of Facial Expressions |
| title_fullStr | Impaired Emotional Mirroring in Parkinson’s Disease—A Study on Brain Activation during Processing of Facial Expressions |
| title_full_unstemmed | Impaired Emotional Mirroring in Parkinson’s Disease—A Study on Brain Activation during Processing of Facial Expressions |
| title_short | Impaired Emotional Mirroring in Parkinson’s Disease—A Study on Brain Activation during Processing of Facial Expressions |
| title_sort | impaired emotional mirroring in parkinson s disease a study on brain activation during processing of facial expressions |
| topic | neurodegeneration mirror neurons emotion functional MRI facial emotions Parkinson’s disease |
| url | http://journal.frontiersin.org/article/10.3389/fneur.2017.00682/full |
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