Altered cerebellar functional connectivity in chronic subcortical stroke patients
BackgroundPrevious studies demonstrated that cerebellar subregions are involved in different functions. Especially the cerebellar anterior lobe (CAL) and cerebellar posterior lobe (CPL) have been postulated to primarily account for sensorimotor and cognitive function, respectively. However, the func...
Main Authors: | , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2022-11-01
|
Series: | Frontiers in Human Neuroscience |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fnhum.2022.1046378/full |
_version_ | 1797984294883295232 |
---|---|
author | Wenjun Hong Wenjun Hong Yilin Du Rong Xu Xin Zhang Zaixing Liu Ming Li Zhixuan Yu Yuxin Wang Minmin Wang Minmin Wang Bo Yang Fenfen Sun Guangxu Xu Guangxu Xu |
author_facet | Wenjun Hong Wenjun Hong Yilin Du Rong Xu Xin Zhang Zaixing Liu Ming Li Zhixuan Yu Yuxin Wang Minmin Wang Minmin Wang Bo Yang Fenfen Sun Guangxu Xu Guangxu Xu |
author_sort | Wenjun Hong |
collection | DOAJ |
description | BackgroundPrevious studies demonstrated that cerebellar subregions are involved in different functions. Especially the cerebellar anterior lobe (CAL) and cerebellar posterior lobe (CPL) have been postulated to primarily account for sensorimotor and cognitive function, respectively. However, the functional connectivity (FC) alterations of CAL and CPL, and their relationships with behavior performance in chronic stroke participants are unclear so far.Materials and methodsThe present study collected resting-state fMRI data from thirty-six subcortical chronic stroke participants and thirty-eight well-matched healthy controls (HCs). We performed the FC analysis with bilateral CAL and CPL as seeds for each participant. Then, we detected the FC difference between the two groups by using a two-sample t-test and evaluated the relationship between the FC and scores of motor and cognitive assessments across all post-stroke participants by using partial correlation analysis.ResultsThe CAL showed increased FCs in the prefrontal cortex, superior/inferior temporal gyrus, and lingual gyrus, while the CPL showed increased FCs in the inferior parietal lobule, precuneus, and cingulum gyrus in the stroke participants compared with HCs. Moreover, the FC alteration in the right CAL and the right CPL were negatively correlated with executive and memory functions across stroke participants, respectively.ConclusionThese findings shed light on the different increased FC alteration patterns of CAL and CPL that help understand the neuro-mechanisms underlying behavior performance in chronic stroke survivors. |
first_indexed | 2024-04-11T07:00:30Z |
format | Article |
id | doaj.art-c7cdff1e05d141ba9d499280484003e7 |
institution | Directory Open Access Journal |
issn | 1662-5161 |
language | English |
last_indexed | 2024-04-11T07:00:30Z |
publishDate | 2022-11-01 |
publisher | Frontiers Media S.A. |
record_format | Article |
series | Frontiers in Human Neuroscience |
spelling | doaj.art-c7cdff1e05d141ba9d499280484003e72022-12-22T04:38:51ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612022-11-011610.3389/fnhum.2022.10463781046378Altered cerebellar functional connectivity in chronic subcortical stroke patientsWenjun Hong0Wenjun Hong1Yilin Du2Rong Xu3Xin Zhang4Zaixing Liu5Ming Li6Zhixuan Yu7Yuxin Wang8Minmin Wang9Minmin Wang10Bo Yang11Fenfen Sun12Guangxu Xu13Guangxu Xu14School of Rehabilitation Medicine, Nanjing Medical University, Nanjing, ChinaDepartment of Rehabilitation Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, ChinaSchool of Rehabilitation Medicine, Nanjing Medical University, Nanjing, ChinaDepartment of Rehabilitation Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, ChinaDepartment of Radiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, ChinaDepartment of Rehabilitation Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, ChinaDepartment of Radiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, ChinaDepartment of Radiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, ChinaDepartment of Rehabilitation Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, ChinaSchool of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, ChinaBinjiang Institute of Zhejiang University, Hangzhou, ChinaDepartment of Rehabilitation Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, ChinaCenter for Brain, Mind, and Education, Shaoxing University, Shaoxing, ChinaSchool of Rehabilitation Medicine, Nanjing Medical University, Nanjing, ChinaDepartment of Rehabilitation Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaBackgroundPrevious studies demonstrated that cerebellar subregions are involved in different functions. Especially the cerebellar anterior lobe (CAL) and cerebellar posterior lobe (CPL) have been postulated to primarily account for sensorimotor and cognitive function, respectively. However, the functional connectivity (FC) alterations of CAL and CPL, and their relationships with behavior performance in chronic stroke participants are unclear so far.Materials and methodsThe present study collected resting-state fMRI data from thirty-six subcortical chronic stroke participants and thirty-eight well-matched healthy controls (HCs). We performed the FC analysis with bilateral CAL and CPL as seeds for each participant. Then, we detected the FC difference between the two groups by using a two-sample t-test and evaluated the relationship between the FC and scores of motor and cognitive assessments across all post-stroke participants by using partial correlation analysis.ResultsThe CAL showed increased FCs in the prefrontal cortex, superior/inferior temporal gyrus, and lingual gyrus, while the CPL showed increased FCs in the inferior parietal lobule, precuneus, and cingulum gyrus in the stroke participants compared with HCs. Moreover, the FC alteration in the right CAL and the right CPL were negatively correlated with executive and memory functions across stroke participants, respectively.ConclusionThese findings shed light on the different increased FC alteration patterns of CAL and CPL that help understand the neuro-mechanisms underlying behavior performance in chronic stroke survivors.https://www.frontiersin.org/articles/10.3389/fnhum.2022.1046378/fullstrokecerebellar anterior lobecerebellar posterior loberesting-state fMRIfunctional connectivity |
spellingShingle | Wenjun Hong Wenjun Hong Yilin Du Rong Xu Xin Zhang Zaixing Liu Ming Li Zhixuan Yu Yuxin Wang Minmin Wang Minmin Wang Bo Yang Fenfen Sun Guangxu Xu Guangxu Xu Altered cerebellar functional connectivity in chronic subcortical stroke patients Frontiers in Human Neuroscience stroke cerebellar anterior lobe cerebellar posterior lobe resting-state fMRI functional connectivity |
title | Altered cerebellar functional connectivity in chronic subcortical stroke patients |
title_full | Altered cerebellar functional connectivity in chronic subcortical stroke patients |
title_fullStr | Altered cerebellar functional connectivity in chronic subcortical stroke patients |
title_full_unstemmed | Altered cerebellar functional connectivity in chronic subcortical stroke patients |
title_short | Altered cerebellar functional connectivity in chronic subcortical stroke patients |
title_sort | altered cerebellar functional connectivity in chronic subcortical stroke patients |
topic | stroke cerebellar anterior lobe cerebellar posterior lobe resting-state fMRI functional connectivity |
url | https://www.frontiersin.org/articles/10.3389/fnhum.2022.1046378/full |
work_keys_str_mv | AT wenjunhong alteredcerebellarfunctionalconnectivityinchronicsubcorticalstrokepatients AT wenjunhong alteredcerebellarfunctionalconnectivityinchronicsubcorticalstrokepatients AT yilindu alteredcerebellarfunctionalconnectivityinchronicsubcorticalstrokepatients AT rongxu alteredcerebellarfunctionalconnectivityinchronicsubcorticalstrokepatients AT xinzhang alteredcerebellarfunctionalconnectivityinchronicsubcorticalstrokepatients AT zaixingliu alteredcerebellarfunctionalconnectivityinchronicsubcorticalstrokepatients AT mingli alteredcerebellarfunctionalconnectivityinchronicsubcorticalstrokepatients AT zhixuanyu alteredcerebellarfunctionalconnectivityinchronicsubcorticalstrokepatients AT yuxinwang alteredcerebellarfunctionalconnectivityinchronicsubcorticalstrokepatients AT minminwang alteredcerebellarfunctionalconnectivityinchronicsubcorticalstrokepatients AT minminwang alteredcerebellarfunctionalconnectivityinchronicsubcorticalstrokepatients AT boyang alteredcerebellarfunctionalconnectivityinchronicsubcorticalstrokepatients AT fenfensun alteredcerebellarfunctionalconnectivityinchronicsubcorticalstrokepatients AT guangxuxu alteredcerebellarfunctionalconnectivityinchronicsubcorticalstrokepatients AT guangxuxu alteredcerebellarfunctionalconnectivityinchronicsubcorticalstrokepatients |