Altered cerebellar functional connectivity in chronic subcortical stroke patients

BackgroundPrevious studies demonstrated that cerebellar subregions are involved in different functions. Especially the cerebellar anterior lobe (CAL) and cerebellar posterior lobe (CPL) have been postulated to primarily account for sensorimotor and cognitive function, respectively. However, the func...

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Main Authors: Wenjun Hong, Yilin Du, Rong Xu, Xin Zhang, Zaixing Liu, Ming Li, Zhixuan Yu, Yuxin Wang, Minmin Wang, Bo Yang, Fenfen Sun, Guangxu Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Human Neuroscience
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fnhum.2022.1046378/full
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author Wenjun Hong
Wenjun Hong
Yilin Du
Rong Xu
Xin Zhang
Zaixing Liu
Ming Li
Zhixuan Yu
Yuxin Wang
Minmin Wang
Minmin Wang
Bo Yang
Fenfen Sun
Guangxu Xu
Guangxu Xu
author_facet Wenjun Hong
Wenjun Hong
Yilin Du
Rong Xu
Xin Zhang
Zaixing Liu
Ming Li
Zhixuan Yu
Yuxin Wang
Minmin Wang
Minmin Wang
Bo Yang
Fenfen Sun
Guangxu Xu
Guangxu Xu
author_sort Wenjun Hong
collection DOAJ
description BackgroundPrevious studies demonstrated that cerebellar subregions are involved in different functions. Especially the cerebellar anterior lobe (CAL) and cerebellar posterior lobe (CPL) have been postulated to primarily account for sensorimotor and cognitive function, respectively. However, the functional connectivity (FC) alterations of CAL and CPL, and their relationships with behavior performance in chronic stroke participants are unclear so far.Materials and methodsThe present study collected resting-state fMRI data from thirty-six subcortical chronic stroke participants and thirty-eight well-matched healthy controls (HCs). We performed the FC analysis with bilateral CAL and CPL as seeds for each participant. Then, we detected the FC difference between the two groups by using a two-sample t-test and evaluated the relationship between the FC and scores of motor and cognitive assessments across all post-stroke participants by using partial correlation analysis.ResultsThe CAL showed increased FCs in the prefrontal cortex, superior/inferior temporal gyrus, and lingual gyrus, while the CPL showed increased FCs in the inferior parietal lobule, precuneus, and cingulum gyrus in the stroke participants compared with HCs. Moreover, the FC alteration in the right CAL and the right CPL were negatively correlated with executive and memory functions across stroke participants, respectively.ConclusionThese findings shed light on the different increased FC alteration patterns of CAL and CPL that help understand the neuro-mechanisms underlying behavior performance in chronic stroke survivors.
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spelling doaj.art-c7cdff1e05d141ba9d499280484003e72022-12-22T04:38:51ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612022-11-011610.3389/fnhum.2022.10463781046378Altered cerebellar functional connectivity in chronic subcortical stroke patientsWenjun Hong0Wenjun Hong1Yilin Du2Rong Xu3Xin Zhang4Zaixing Liu5Ming Li6Zhixuan Yu7Yuxin Wang8Minmin Wang9Minmin Wang10Bo Yang11Fenfen Sun12Guangxu Xu13Guangxu Xu14School of Rehabilitation Medicine, Nanjing Medical University, Nanjing, ChinaDepartment of Rehabilitation Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, ChinaSchool of Rehabilitation Medicine, Nanjing Medical University, Nanjing, ChinaDepartment of Rehabilitation Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, ChinaDepartment of Radiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, ChinaDepartment of Rehabilitation Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, ChinaDepartment of Radiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, ChinaDepartment of Radiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, ChinaDepartment of Rehabilitation Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, ChinaSchool of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, ChinaBinjiang Institute of Zhejiang University, Hangzhou, ChinaDepartment of Rehabilitation Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, ChinaCenter for Brain, Mind, and Education, Shaoxing University, Shaoxing, ChinaSchool of Rehabilitation Medicine, Nanjing Medical University, Nanjing, ChinaDepartment of Rehabilitation Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaBackgroundPrevious studies demonstrated that cerebellar subregions are involved in different functions. Especially the cerebellar anterior lobe (CAL) and cerebellar posterior lobe (CPL) have been postulated to primarily account for sensorimotor and cognitive function, respectively. However, the functional connectivity (FC) alterations of CAL and CPL, and their relationships with behavior performance in chronic stroke participants are unclear so far.Materials and methodsThe present study collected resting-state fMRI data from thirty-six subcortical chronic stroke participants and thirty-eight well-matched healthy controls (HCs). We performed the FC analysis with bilateral CAL and CPL as seeds for each participant. Then, we detected the FC difference between the two groups by using a two-sample t-test and evaluated the relationship between the FC and scores of motor and cognitive assessments across all post-stroke participants by using partial correlation analysis.ResultsThe CAL showed increased FCs in the prefrontal cortex, superior/inferior temporal gyrus, and lingual gyrus, while the CPL showed increased FCs in the inferior parietal lobule, precuneus, and cingulum gyrus in the stroke participants compared with HCs. Moreover, the FC alteration in the right CAL and the right CPL were negatively correlated with executive and memory functions across stroke participants, respectively.ConclusionThese findings shed light on the different increased FC alteration patterns of CAL and CPL that help understand the neuro-mechanisms underlying behavior performance in chronic stroke survivors.https://www.frontiersin.org/articles/10.3389/fnhum.2022.1046378/fullstrokecerebellar anterior lobecerebellar posterior loberesting-state fMRIfunctional connectivity
spellingShingle Wenjun Hong
Wenjun Hong
Yilin Du
Rong Xu
Xin Zhang
Zaixing Liu
Ming Li
Zhixuan Yu
Yuxin Wang
Minmin Wang
Minmin Wang
Bo Yang
Fenfen Sun
Guangxu Xu
Guangxu Xu
Altered cerebellar functional connectivity in chronic subcortical stroke patients
Frontiers in Human Neuroscience
stroke
cerebellar anterior lobe
cerebellar posterior lobe
resting-state fMRI
functional connectivity
title Altered cerebellar functional connectivity in chronic subcortical stroke patients
title_full Altered cerebellar functional connectivity in chronic subcortical stroke patients
title_fullStr Altered cerebellar functional connectivity in chronic subcortical stroke patients
title_full_unstemmed Altered cerebellar functional connectivity in chronic subcortical stroke patients
title_short Altered cerebellar functional connectivity in chronic subcortical stroke patients
title_sort altered cerebellar functional connectivity in chronic subcortical stroke patients
topic stroke
cerebellar anterior lobe
cerebellar posterior lobe
resting-state fMRI
functional connectivity
url https://www.frontiersin.org/articles/10.3389/fnhum.2022.1046378/full
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