The Role of Testosterone in the Elderly: What Do We Know?
Testosterone is the most important hormone in male health. Aging is characterized by testosterone deficiency due to decreasing testosterone levels associated with low testicular production, genetic factors, adiposity, and illness. Low testosterone levels in men are associated with sexual dysfunction...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/7/3535 |
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| author | Biagio Barone Luigi Napolitano Marco Abate Luigi Cirillo Pasquale Reccia Francesco Passaro Carmine Turco Simone Morra Francesco Mastrangelo Antonio Scarpato Ugo Amicuzi Vincenzo Morgera Lorenzo Romano Francesco Paolo Calace Savio Domenico Pandolfo Luigi De Luca Achille Aveta Enrico Sicignano Massimiliano Trivellato Gianluca Spena Carlo D’Alterio Giovanni Maria Fusco Raffaele Vitale Davide Arcaniolo Felice Crocetto |
| author_facet | Biagio Barone Luigi Napolitano Marco Abate Luigi Cirillo Pasquale Reccia Francesco Passaro Carmine Turco Simone Morra Francesco Mastrangelo Antonio Scarpato Ugo Amicuzi Vincenzo Morgera Lorenzo Romano Francesco Paolo Calace Savio Domenico Pandolfo Luigi De Luca Achille Aveta Enrico Sicignano Massimiliano Trivellato Gianluca Spena Carlo D’Alterio Giovanni Maria Fusco Raffaele Vitale Davide Arcaniolo Felice Crocetto |
| author_sort | Biagio Barone |
| collection | DOAJ |
| description | Testosterone is the most important hormone in male health. Aging is characterized by testosterone deficiency due to decreasing testosterone levels associated with low testicular production, genetic factors, adiposity, and illness. Low testosterone levels in men are associated with sexual dysfunction (low sexual desire, erectile dysfunction), reduced skeletal muscle mass and strength, decreased bone mineral density, increased cardiovascular risk and alterations of the glycometabolic profile. Testosterone replacement therapy (TRT) shows several therapeutic effects while maintaining a good safety profile in hypogonadal men. TRT restores normal levels of serum testosterone in men, increasing libido and energy level and producing beneficial effects on bone density, strength and muscle as well as yielding cardioprotective effects. Nevertheless, TRT could be contraindicated in men with untreated prostate cancer, although poor findings are reported in the literature. In addition, different potential side effects, such as polycythemia, cardiac events and obstructive sleep apnea, should be monitored. The aim of our review is to provide an updated background regarding the pros and cons of TRT, evaluating its role and its clinical applicability in different domains. |
| first_indexed | 2024-03-09T11:48:48Z |
| format | Article |
| id | doaj.art-c7ce796ec5484114ae406db45a34c6de |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T11:48:48Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-c7ce796ec5484114ae406db45a34c6de2023-11-30T23:18:20ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-03-01237353510.3390/ijms23073535The Role of Testosterone in the Elderly: What Do We Know?Biagio Barone0Luigi Napolitano1Marco Abate2Luigi Cirillo3Pasquale Reccia4Francesco Passaro5Carmine Turco6Simone Morra7Francesco Mastrangelo8Antonio Scarpato9Ugo Amicuzi10Vincenzo Morgera11Lorenzo Romano12Francesco Paolo Calace13Savio Domenico Pandolfo14Luigi De Luca15Achille Aveta16Enrico Sicignano17Massimiliano Trivellato18Gianluca Spena19Carlo D’Alterio20Giovanni Maria Fusco21Raffaele Vitale22Davide Arcaniolo23Felice Crocetto24Department of Neurosciences, Science of Reproduction and Odontostomatology, University of Naples Federico II, 80131 Naples, ItalyDepartment of Neurosciences, Science of Reproduction and Odontostomatology, University of Naples Federico II, 80131 Naples, ItalyDepartment of Neurosciences, Science of Reproduction and Odontostomatology, University of Naples Federico II, 80131 Naples, ItalyDepartment of Neurosciences, Science of Reproduction and Odontostomatology, University of Naples Federico II, 80131 Naples, ItalyDepartment of Neurosciences, Science of Reproduction and Odontostomatology, University of Naples Federico II, 80131 Naples, ItalyDepartment of Neurosciences, Science of Reproduction and Odontostomatology, University of Naples Federico II, 80131 Naples, ItalyDepartment of Neurosciences, Science of Reproduction and Odontostomatology, University of Naples Federico II, 80131 Naples, ItalyDepartment of Neurosciences, Science of Reproduction and Odontostomatology, University of Naples Federico II, 80131 Naples, ItalyDepartment of Neurosciences, Science of Reproduction and Odontostomatology, University of Naples Federico II, 80131 Naples, ItalyDepartment of Neurosciences, Science of Reproduction and Odontostomatology, University of Naples Federico II, 80131 Naples, ItalyDepartment of Neurosciences, Science of Reproduction and Odontostomatology, University of Naples Federico II, 80131 Naples, ItalyDepartment of Neurosciences, Science of Reproduction and Odontostomatology, University of Naples Federico II, 80131 Naples, ItalyDepartment of Neurosciences, Science of Reproduction and Odontostomatology, University of Naples Federico II, 80131 Naples, ItalyDepartment of Neurosciences, Science of Reproduction and Odontostomatology, University of Naples Federico II, 80131 Naples, ItalyDepartment of Neurosciences, Science of Reproduction and Odontostomatology, University of Naples Federico II, 80131 Naples, ItalyDepartment of Neurosciences, Science of Reproduction and Odontostomatology, University of Naples Federico II, 80131 Naples, ItalyDepartment of Neurosciences, Science of Reproduction and Odontostomatology, University of Naples Federico II, 80131 Naples, ItalyDepartment of Neurosciences, Science of Reproduction and Odontostomatology, University of Naples Federico II, 80131 Naples, ItalyDepartment of Neurosciences, Science of Reproduction and Odontostomatology, University of Naples Federico II, 80131 Naples, ItalyDepartment of Neurosciences, Science of Reproduction and Odontostomatology, University of Naples Federico II, 80131 Naples, ItalyDepartment of Neurosciences, Science of Reproduction and Odontostomatology, University of Naples Federico II, 80131 Naples, ItalyDepartment of Neurosciences, Science of Reproduction and Odontostomatology, University of Naples Federico II, 80131 Naples, ItalyDivision of Urology, AORN “San Giuseppe Moscati”, 83100 Avellino, ItalyUrology Unit, Department of Woman, Child and General and Specialized Surgery, University of Campania ‘Luigi Vanvitelli’, 80131 Naples, ItalyDepartment of Neurosciences, Science of Reproduction and Odontostomatology, University of Naples Federico II, 80131 Naples, ItalyTestosterone is the most important hormone in male health. Aging is characterized by testosterone deficiency due to decreasing testosterone levels associated with low testicular production, genetic factors, adiposity, and illness. Low testosterone levels in men are associated with sexual dysfunction (low sexual desire, erectile dysfunction), reduced skeletal muscle mass and strength, decreased bone mineral density, increased cardiovascular risk and alterations of the glycometabolic profile. Testosterone replacement therapy (TRT) shows several therapeutic effects while maintaining a good safety profile in hypogonadal men. TRT restores normal levels of serum testosterone in men, increasing libido and energy level and producing beneficial effects on bone density, strength and muscle as well as yielding cardioprotective effects. Nevertheless, TRT could be contraindicated in men with untreated prostate cancer, although poor findings are reported in the literature. In addition, different potential side effects, such as polycythemia, cardiac events and obstructive sleep apnea, should be monitored. The aim of our review is to provide an updated background regarding the pros and cons of TRT, evaluating its role and its clinical applicability in different domains.https://www.mdpi.com/1422-0067/23/7/3535testosteroneagingreplacement therapyerectile dysfunctionmetabolic syndromedepression |
| spellingShingle | Biagio Barone Luigi Napolitano Marco Abate Luigi Cirillo Pasquale Reccia Francesco Passaro Carmine Turco Simone Morra Francesco Mastrangelo Antonio Scarpato Ugo Amicuzi Vincenzo Morgera Lorenzo Romano Francesco Paolo Calace Savio Domenico Pandolfo Luigi De Luca Achille Aveta Enrico Sicignano Massimiliano Trivellato Gianluca Spena Carlo D’Alterio Giovanni Maria Fusco Raffaele Vitale Davide Arcaniolo Felice Crocetto The Role of Testosterone in the Elderly: What Do We Know? International Journal of Molecular Sciences testosterone aging replacement therapy erectile dysfunction metabolic syndrome depression |
| title | The Role of Testosterone in the Elderly: What Do We Know? |
| title_full | The Role of Testosterone in the Elderly: What Do We Know? |
| title_fullStr | The Role of Testosterone in the Elderly: What Do We Know? |
| title_full_unstemmed | The Role of Testosterone in the Elderly: What Do We Know? |
| title_short | The Role of Testosterone in the Elderly: What Do We Know? |
| title_sort | role of testosterone in the elderly what do we know |
| topic | testosterone aging replacement therapy erectile dysfunction metabolic syndrome depression |
| url | https://www.mdpi.com/1422-0067/23/7/3535 |
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