Verteporfin Inhibits the Progression of Spontaneous Osteosarcoma Caused by Trp53 and Rb1 Deficiency in Ctsk-Expressing Cells via Impeding Hippo Pathway

Verteporfin Inhibits the Progression of Spontaneous Osteosarcoma Caused by Trp53 and Rb1 Deficiency in Ctsk-Expressing Cells via Impeding Hippo Pathway

Osteosarcoma is the most common primary malignancy of bone in children and adolescents. Others and our previous studies have shown that Yes-associated protein (YAP)/transcriptional coactivator with PDZ-binding motif (TAZ) as core components of the Hippo pathway are crucial regulators of osteosarcoma...

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Bibliographic Details
Main Authors: Yang Li, Shuting Yang, Shuying Yang
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Cells
Subjects:
osteosarcoma
Trp53
Rb1
YAP/TAZ
verteporfin
Online Access:https://www.mdpi.com/2073-4409/11/8/1361

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