DNA Physical Properties and Nucleosome Positions Are Major Determinants of HIV-1 Integrase Selectivity.

DNA Physical Properties and Nucleosome Positions Are Major Determinants of HIV-1 Integrase Selectivity.

Retroviral integrases (INs) catalyse the integration of the reverse transcribed viral DNA into the host cell genome. This process is selective, and chromatin has been proposed to be a major factor regulating this step in the viral life cycle. However, the precise underlying mechanisms are still unde...

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Bibliographic Details
Main Authors: Monica Naughtin, Zofia Haftek-Terreau, Johan Xavier, Sam Meyer, Maud Silvain, Yan Jaszczyszyn, Nicolas Levy, Vincent Miele, Mohamed Salah Benleulmi, Marc Ruff, Vincent Parissi, Cédric Vaillant, Marc Lavigne
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4468133?pdf=render

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