Pathology review of proliferative lesions of the exocrine pancreas in two chronic feeding studies in rats with ammonium perfluorooctanoate
Two chronic dietary studies, conducted years apart, with ammonium perfluorooctanoate (APFO) in Sprague Dawley rats have been previously reported. Although both included male 300 ppm dietary dose groups, only the later study, conducted in 1990–1992 by Biegel et al., reported an increase in proliferat...
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| Format: | Article |
| Language: | English |
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Elsevier
2014-01-01
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| Series: | Toxicology Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214750014000171 |
| _version_ | 1818911096824659968 |
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| author | Jessica M. Caverly Rae Steven R. Frame Gerald L. Kennedy John L. Butenhoff Shu-Ching Chang |
| author_facet | Jessica M. Caverly Rae Steven R. Frame Gerald L. Kennedy John L. Butenhoff Shu-Ching Chang |
| author_sort | Jessica M. Caverly Rae |
| collection | DOAJ |
| description | Two chronic dietary studies, conducted years apart, with ammonium perfluorooctanoate (APFO) in Sprague Dawley rats have been previously reported. Although both included male 300 ppm dietary dose groups, only the later study, conducted in 1990–1992 by Biegel et al., reported an increase in proliferative lesions (hyperplasia and adenoma) of the acinar pancreas. An assessment of the significance of the differences between both studies requires careful consideration of: the diagnostic criteria for proliferative acinar cell lesions of the rat pancreas (for example, the diagnosis of pancreatic acinar cell hyperplasia versus adenoma is based on the two-dimensional size of the lesion rather than distinct morphological differences); the basis for those criteria in light of their relevance to biological behavior; and the potential diagnostic variability between individual pathologists for difficult-to-classify lesions. A pathology peer review of male exocrine pancreatic tissues from the earlier study, conducted in 1981–1983 by Butenhoff et al., was undertaken. This review identified an increase in acinar cell hyperplasia but not adenoma or carcinoma in the earlier study. Both studies observed a proliferative response in the acinar pancreas which was more pronounced in the study by Biegel et al. Definitive reasons for the greater incidence of proliferative lesions in the later study were not identified, but some possible explanations are presented herein. The relevance of this finding to human risk assessment, in the face of differences in the biological behavior of human and rat pancreatic proliferative lesions and the proposed mechanism of formation of these lesions, are questionable. |
| first_indexed | 2024-12-19T22:53:16Z |
| format | Article |
| id | doaj.art-c7d0dfff3a9e461da2d79892b3e64295 |
| institution | Directory Open Access Journal |
| issn | 2214-7500 |
| language | English |
| last_indexed | 2024-12-19T22:53:16Z |
| publishDate | 2014-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Toxicology Reports |
| spelling | doaj.art-c7d0dfff3a9e461da2d79892b3e642952022-12-21T20:02:43ZengElsevierToxicology Reports2214-75002014-01-011C859110.1016/j.toxrep.2014.04.005Pathology review of proliferative lesions of the exocrine pancreas in two chronic feeding studies in rats with ammonium perfluorooctanoateJessica M. Caverly Rae0Steven R. Frame1Gerald L. Kennedy2John L. Butenhoff3Shu-Ching Chang4DuPont Haskell Global Centers, Newark, DE 19714, USADuPont Haskell Global Centers, Newark, DE 19714, USAConsultant to DuPont Company, Wilmington, DE 19805, USA3M Company, Medical Department, 3M Center 220-06-W-08, Saint Paul, MN 55144, USA3M Company, Medical Department, 3M Center 220-06-W-08, Saint Paul, MN 55144, USATwo chronic dietary studies, conducted years apart, with ammonium perfluorooctanoate (APFO) in Sprague Dawley rats have been previously reported. Although both included male 300 ppm dietary dose groups, only the later study, conducted in 1990–1992 by Biegel et al., reported an increase in proliferative lesions (hyperplasia and adenoma) of the acinar pancreas. An assessment of the significance of the differences between both studies requires careful consideration of: the diagnostic criteria for proliferative acinar cell lesions of the rat pancreas (for example, the diagnosis of pancreatic acinar cell hyperplasia versus adenoma is based on the two-dimensional size of the lesion rather than distinct morphological differences); the basis for those criteria in light of their relevance to biological behavior; and the potential diagnostic variability between individual pathologists for difficult-to-classify lesions. A pathology peer review of male exocrine pancreatic tissues from the earlier study, conducted in 1981–1983 by Butenhoff et al., was undertaken. This review identified an increase in acinar cell hyperplasia but not adenoma or carcinoma in the earlier study. Both studies observed a proliferative response in the acinar pancreas which was more pronounced in the study by Biegel et al. Definitive reasons for the greater incidence of proliferative lesions in the later study were not identified, but some possible explanations are presented herein. The relevance of this finding to human risk assessment, in the face of differences in the biological behavior of human and rat pancreatic proliferative lesions and the proposed mechanism of formation of these lesions, are questionable.http://www.sciencedirect.com/science/article/pii/S2214750014000171PerfluorooctanoatePFOAPancreasPathologyAPFORats |
| spellingShingle | Jessica M. Caverly Rae Steven R. Frame Gerald L. Kennedy John L. Butenhoff Shu-Ching Chang Pathology review of proliferative lesions of the exocrine pancreas in two chronic feeding studies in rats with ammonium perfluorooctanoate Toxicology Reports Perfluorooctanoate PFOA Pancreas Pathology APFO Rats |
| title | Pathology review of proliferative lesions of the exocrine pancreas in two chronic feeding studies in rats with ammonium perfluorooctanoate |
| title_full | Pathology review of proliferative lesions of the exocrine pancreas in two chronic feeding studies in rats with ammonium perfluorooctanoate |
| title_fullStr | Pathology review of proliferative lesions of the exocrine pancreas in two chronic feeding studies in rats with ammonium perfluorooctanoate |
| title_full_unstemmed | Pathology review of proliferative lesions of the exocrine pancreas in two chronic feeding studies in rats with ammonium perfluorooctanoate |
| title_short | Pathology review of proliferative lesions of the exocrine pancreas in two chronic feeding studies in rats with ammonium perfluorooctanoate |
| title_sort | pathology review of proliferative lesions of the exocrine pancreas in two chronic feeding studies in rats with ammonium perfluorooctanoate |
| topic | Perfluorooctanoate PFOA Pancreas Pathology APFO Rats |
| url | http://www.sciencedirect.com/science/article/pii/S2214750014000171 |
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