Formulation, characterization, in vitro and in vivo evaluations of self-nanoemulsifying drug delivery system of luteolin
The purpose of this study was to develop a self-nanoemulsifying drug delivery system (SNEDDS) for the improvement of solubility and bioavailability of luteolin in order to enhance its therapeutic benefits. Formulations were prepared by spontaneous emulsification method which involved low energy mixi...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2020-01-01
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| Series: | Journal of Taibah University for Science |
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| Online Access: | http://dx.doi.org/10.1080/16583655.2020.1812269 |
| _version_ | 1818950279974879232 |
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| author | Mohammad Javed Ansari Abdullah Alshetaili Ibrahim Abdulaziz Aldayel Faisal Mohammed Alablan Bader Alsulays Saad Alshahrani Ahmad Alalaiwe Mohd Nazam Ansari Najeeb Ur Rehman Faiyaz Shakeel |
| author_facet | Mohammad Javed Ansari Abdullah Alshetaili Ibrahim Abdulaziz Aldayel Faisal Mohammed Alablan Bader Alsulays Saad Alshahrani Ahmad Alalaiwe Mohd Nazam Ansari Najeeb Ur Rehman Faiyaz Shakeel |
| author_sort | Mohammad Javed Ansari |
| collection | DOAJ |
| description | The purpose of this study was to develop a self-nanoemulsifying drug delivery system (SNEDDS) for the improvement of solubility and bioavailability of luteolin in order to enhance its therapeutic benefits. Formulations were prepared by spontaneous emulsification method which involved low energy mixing of appropriate amounts ofcastor oil, kolliphor & polyethylene glycol 200. The developed formulae were optimized and characterized for self-nanoemulsifying capacity, thermodynamic stability, size behaviour and solubility. The globule size of the optimized formula F1–A1:1 was 112 ± 15 nm, with narrow PDI (0.31 ± 0.09) and good zeta potential (−16.2 ± 3.2 mV). The optimized formula exhibited approximately 83, 17 and 3-fold enhancement in the solubility in vitro release and ex vivo permeation respectively. The luteolin SNEDD exhibited better antioxidant activity (DPPH scavenging activity) than ascorbic acid. Per cent inhibition in rat paw oedema by the SNEDDS formulation was statistically significant when compared with luteolin suspension at equivalent dose (P < 0.05). |
| first_indexed | 2024-12-20T09:16:04Z |
| format | Article |
| id | doaj.art-c7d0ff560bba435b8c96d1c2d5015cb9 |
| institution | Directory Open Access Journal |
| issn | 1658-3655 |
| language | English |
| last_indexed | 2024-12-20T09:16:04Z |
| publishDate | 2020-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Taibah University for Science |
| spelling | doaj.art-c7d0ff560bba435b8c96d1c2d5015cb92022-12-21T19:45:25ZengTaylor & Francis GroupJournal of Taibah University for Science1658-36552020-01-011411386140110.1080/16583655.2020.18122691812269Formulation, characterization, in vitro and in vivo evaluations of self-nanoemulsifying drug delivery system of luteolinMohammad Javed Ansari0Abdullah Alshetaili1Ibrahim Abdulaziz Aldayel2Faisal Mohammed Alablan3Bader Alsulays4Saad Alshahrani5Ahmad Alalaiwe6Mohd Nazam Ansari7Najeeb Ur Rehman8Faiyaz Shakeel9Department of Pharmaceutics, College of Pharmacy, Prince Sattam Bin Abdulaziz UniversityDepartment of Pharmaceutics, College of Pharmacy, Prince Sattam Bin Abdulaziz UniversityDepartment of Pharmaceutics, College of Pharmacy, Prince Sattam Bin Abdulaziz UniversityDepartment of Pharmaceutics, College of Pharmacy, Prince Sattam Bin Abdulaziz UniversityDepartment of Pharmaceutics, College of Pharmacy, Prince Sattam Bin Abdulaziz UniversityDepartment of Pharmaceutics, College of Pharmacy, Prince Sattam Bin Abdulaziz UniversityDepartment of Pharmaceutics, College of Pharmacy, Prince Sattam Bin Abdulaziz UniversityDepartment of Pharmacology and Toxicology, College of Pharmacy, Prince Sattam Bin Abdulaziz UniversityDepartment of Pharmacology and Toxicology, College of Pharmacy, Prince Sattam Bin Abdulaziz UniversityDepartment of Pharmaceutics, College of Pharmacy, King Saud UniversityThe purpose of this study was to develop a self-nanoemulsifying drug delivery system (SNEDDS) for the improvement of solubility and bioavailability of luteolin in order to enhance its therapeutic benefits. Formulations were prepared by spontaneous emulsification method which involved low energy mixing of appropriate amounts ofcastor oil, kolliphor & polyethylene glycol 200. The developed formulae were optimized and characterized for self-nanoemulsifying capacity, thermodynamic stability, size behaviour and solubility. The globule size of the optimized formula F1–A1:1 was 112 ± 15 nm, with narrow PDI (0.31 ± 0.09) and good zeta potential (−16.2 ± 3.2 mV). The optimized formula exhibited approximately 83, 17 and 3-fold enhancement in the solubility in vitro release and ex vivo permeation respectively. The luteolin SNEDD exhibited better antioxidant activity (DPPH scavenging activity) than ascorbic acid. Per cent inhibition in rat paw oedema by the SNEDDS formulation was statistically significant when compared with luteolin suspension at equivalent dose (P < 0.05).http://dx.doi.org/10.1080/16583655.2020.1812269luteolinself-nanoemulsifying systemsolubilitypermeationdpphanti-inflammatory |
| spellingShingle | Mohammad Javed Ansari Abdullah Alshetaili Ibrahim Abdulaziz Aldayel Faisal Mohammed Alablan Bader Alsulays Saad Alshahrani Ahmad Alalaiwe Mohd Nazam Ansari Najeeb Ur Rehman Faiyaz Shakeel Formulation, characterization, in vitro and in vivo evaluations of self-nanoemulsifying drug delivery system of luteolin Journal of Taibah University for Science luteolin self-nanoemulsifying system solubility permeation dpph anti-inflammatory |
| title | Formulation, characterization, in vitro and in vivo evaluations of self-nanoemulsifying drug delivery system of luteolin |
| title_full | Formulation, characterization, in vitro and in vivo evaluations of self-nanoemulsifying drug delivery system of luteolin |
| title_fullStr | Formulation, characterization, in vitro and in vivo evaluations of self-nanoemulsifying drug delivery system of luteolin |
| title_full_unstemmed | Formulation, characterization, in vitro and in vivo evaluations of self-nanoemulsifying drug delivery system of luteolin |
| title_short | Formulation, characterization, in vitro and in vivo evaluations of self-nanoemulsifying drug delivery system of luteolin |
| title_sort | formulation characterization in vitro and in vivo evaluations of self nanoemulsifying drug delivery system of luteolin |
| topic | luteolin self-nanoemulsifying system solubility permeation dpph anti-inflammatory |
| url | http://dx.doi.org/10.1080/16583655.2020.1812269 |
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