Moderate Differences in Feeding Diets Largely Affect Motivation and Spatial Cognition in Adult and Aged but Less in Young Male Rats
Nutrition can have significant effects on behavior and cognitive processes. Most of the studies related to this use extremely modified diets, such as high fat contents or the exclusion of distinct components needed for normal development and bodily homeostasis. Here we report significant effects of...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-08-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fnagi.2018.00249/full |
| _version_ | 1819011140574773248 |
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| author | Jovana Maliković Daniel D. Feyissa Ahmed M. Hussein Ahmed M. Hussein Harald Höger Gert Lubec Volker Korz |
| author_facet | Jovana Maliković Daniel D. Feyissa Ahmed M. Hussein Ahmed M. Hussein Harald Höger Gert Lubec Volker Korz |
| author_sort | Jovana Maliković |
| collection | DOAJ |
| description | Nutrition can have significant effects on behavior and cognitive processes. Most of the studies related to this use extremely modified diets, such as high fat contents or the exclusion of distinct components needed for normal development and bodily homeostasis. Here we report significant effects of diets with moderate differences in compositions on food rewarded spatial learning in young (3–4 months), adult (6–7 months), and aged (17–18 months) rats. Young rats fed with a lower energy diet showed better performance only during aquisition of the spatial task when compared to rats fed with a standard diet. Adult rats (6–7 months) fed with a standard diet performed less well in the spatial learning task, than rats fed with lower energy diet. Aged rats fed with a lower energy diet (from 13 to 18 months of age) performed better during all training phases, as in a previous test when they were adult and fed with a standard diet. This difference could only be partly explained by lower motivation to search for food in the first test. Correspondingly, the variability of individual performance was significantly higher and increased over trials in adult rats fed with the standard diet as compared to adult rats fed with lower energy diet. Thus, moderate changes in feeding diets have large effects on motivation and cognition in elderly and less in young rats in a food rewarded spatial learning task. Therefore, nutrition effects upon food rewarded spatial learning and memory should be considered especially in aging studies. |
| first_indexed | 2024-12-21T01:23:26Z |
| format | Article |
| id | doaj.art-c7d1e22b604d4418947128c632b0a055 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-12-21T01:23:26Z |
| publishDate | 2018-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-c7d1e22b604d4418947128c632b0a0552022-12-21T19:20:35ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652018-08-011010.3389/fnagi.2018.00249379301Moderate Differences in Feeding Diets Largely Affect Motivation and Spatial Cognition in Adult and Aged but Less in Young Male RatsJovana Maliković0Daniel D. Feyissa1Ahmed M. Hussein2Ahmed M. Hussein3Harald Höger4Gert Lubec5Volker Korz6Department of Pharmaceutical Chemistry, University of Vienna, Vienna, AustriaDepartment of Pharmaceutical Chemistry, University of Vienna, Vienna, AustriaDepartment of Pharmaceutical Chemistry, University of Vienna, Vienna, AustriaDepartment of Zoology, Faculty of Science, Al-Azhar University, Assiut, EgyptCore Unit of Biomedical Research, Division of Laboratory Animal Science and Genetics, Medical University of Vienna, Vienna, AustriaDepartment of Neuroproteomics, Paracelsus Medical University, Salzburg, AustriaCenter for Brain Research, Medical University of Vienna, Vienna, AustriaNutrition can have significant effects on behavior and cognitive processes. Most of the studies related to this use extremely modified diets, such as high fat contents or the exclusion of distinct components needed for normal development and bodily homeostasis. Here we report significant effects of diets with moderate differences in compositions on food rewarded spatial learning in young (3–4 months), adult (6–7 months), and aged (17–18 months) rats. Young rats fed with a lower energy diet showed better performance only during aquisition of the spatial task when compared to rats fed with a standard diet. Adult rats (6–7 months) fed with a standard diet performed less well in the spatial learning task, than rats fed with lower energy diet. Aged rats fed with a lower energy diet (from 13 to 18 months of age) performed better during all training phases, as in a previous test when they were adult and fed with a standard diet. This difference could only be partly explained by lower motivation to search for food in the first test. Correspondingly, the variability of individual performance was significantly higher and increased over trials in adult rats fed with the standard diet as compared to adult rats fed with lower energy diet. Thus, moderate changes in feeding diets have large effects on motivation and cognition in elderly and less in young rats in a food rewarded spatial learning task. Therefore, nutrition effects upon food rewarded spatial learning and memory should be considered especially in aging studies.https://www.frontiersin.org/article/10.3389/fnagi.2018.00249/fullnutritional statusaging neurosciencestatisticsindividualityfood reward responsivity |
| spellingShingle | Jovana Maliković Daniel D. Feyissa Ahmed M. Hussein Ahmed M. Hussein Harald Höger Gert Lubec Volker Korz Moderate Differences in Feeding Diets Largely Affect Motivation and Spatial Cognition in Adult and Aged but Less in Young Male Rats Frontiers in Aging Neuroscience nutritional status aging neuroscience statistics individuality food reward responsivity |
| title | Moderate Differences in Feeding Diets Largely Affect Motivation and Spatial Cognition in Adult and Aged but Less in Young Male Rats |
| title_full | Moderate Differences in Feeding Diets Largely Affect Motivation and Spatial Cognition in Adult and Aged but Less in Young Male Rats |
| title_fullStr | Moderate Differences in Feeding Diets Largely Affect Motivation and Spatial Cognition in Adult and Aged but Less in Young Male Rats |
| title_full_unstemmed | Moderate Differences in Feeding Diets Largely Affect Motivation and Spatial Cognition in Adult and Aged but Less in Young Male Rats |
| title_short | Moderate Differences in Feeding Diets Largely Affect Motivation and Spatial Cognition in Adult and Aged but Less in Young Male Rats |
| title_sort | moderate differences in feeding diets largely affect motivation and spatial cognition in adult and aged but less in young male rats |
| topic | nutritional status aging neuroscience statistics individuality food reward responsivity |
| url | https://www.frontiersin.org/article/10.3389/fnagi.2018.00249/full |
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