Trends in Antimicrobial Drug Resistance of <i>Streptococcus pneumoniae</i> Isolates at Jordan University Hospital (2000–2018)
Antimicrobial drug resistance (AMR) in pneumococci complicates the treatment of serious pneumococcal infections. Country-specific AMR patterns can help to establish guidelines for empiric therapy. The aim of the current study was to analyze the distribution of AMR among <i>Streptococcus pneumo...
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MDPI AG
2019-04-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/8/2/41 |
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| author | Malik Sallam Jumana Abbadi Anas Natsheh Nidaa A. Ababneh Azmi Mahafzah Gülşen Özkaya Şahin |
| author_facet | Malik Sallam Jumana Abbadi Anas Natsheh Nidaa A. Ababneh Azmi Mahafzah Gülşen Özkaya Şahin |
| author_sort | Malik Sallam |
| collection | DOAJ |
| description | Antimicrobial drug resistance (AMR) in pneumococci complicates the treatment of serious pneumococcal infections. Country-specific AMR patterns can help to establish guidelines for empiric therapy. The aim of the current study was to analyze the distribution of AMR among <i>Streptococcus pneumoniae</i> isolates at Jordan University Hospital (JUH) during 2000–2018. Paper-based and electronic clinical data registry records from 2000 to 2018 were retrospectively analyzed to study the AMR among pneumococcal isolates at JUH. Temporal trend analysis was done using two-tailed linear-by-linear test for association. The total number of unique pneumococcal isolates that were identified was 556, of which 544 isolates had antimicrobial susceptibility testing results. The most frequent specimens were eye (<i>n</i> = 117, 21.0%), bloodstream (<i>n</i> = 93, 16.7%) and sputum (<i>n</i> = 81, 14.6%). Invasive infections represented 23.6% of all unique isolates. The overall susceptibility of <i>S. pneumoniae</i> isolates during the study period to different antimicrobials was: 100% to vancomycin, 97.7% to ceftriaxone, 97.1% to cefotaxime, 94.9% to chloramphenicol, 89.7% to penicillin, 83.8% to levofloxacin, 67.7% to clindamycin and 52.1% to erythromycin. The prevalence of multi-drug resistance (MDR) was 8.6% (95% confidence interval: 6.4–11.5%). Trend analysis showed an increase in the prevalence of non-susceptibility to erythromycin, clindamycin and levofloxacin (<i>p</i> < 0.001). MDR prevalence increased from 1.6% in the first quarter to 14.6% in the fourth quarter (<i>p</i> < 0.001). The incidence of invasive infections declined over the study period (<i>p</i> < 0.001). The increase in the prevalence of AMR and MDR among pneumococcal isolates in Jordan demands judicious use of antimicrobials and regular surveillance of resistance. |
| first_indexed | 2024-12-21T19:27:56Z |
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| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-12-21T19:27:56Z |
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| series | Antibiotics |
| spelling | doaj.art-c7d1ebed490042c58e014c556abe8dcd2022-12-21T18:52:47ZengMDPI AGAntibiotics2079-63822019-04-01824110.3390/antibiotics8020041antibiotics8020041Trends in Antimicrobial Drug Resistance of <i>Streptococcus pneumoniae</i> Isolates at Jordan University Hospital (2000–2018)Malik Sallam0Jumana Abbadi1Anas Natsheh2Nidaa A. Ababneh3Azmi Mahafzah4Gülşen Özkaya Şahin5Department of Pathology, Microbiology and Forensic Medicine, School of Medicine, The University of Jordan, Amman 19328, JordanDepartment of Pathology, Microbiology and Forensic Medicine, School of Medicine, The University of Jordan, Amman 19328, JordanDepartment of Pathology, Microbiology and Forensic Medicine, School of Medicine, The University of Jordan, Amman 19328, JordanCell Therapy Center (CTC), The University of Jordan, Amman 19328, JordanDepartment of Pathology, Microbiology and Forensic Medicine, School of Medicine, The University of Jordan, Amman 19328, JordanDepartment of Translational Medicine, Faculty of Medicine, Lund University, 22362 Malmö, SwedenAntimicrobial drug resistance (AMR) in pneumococci complicates the treatment of serious pneumococcal infections. Country-specific AMR patterns can help to establish guidelines for empiric therapy. The aim of the current study was to analyze the distribution of AMR among <i>Streptococcus pneumoniae</i> isolates at Jordan University Hospital (JUH) during 2000–2018. Paper-based and electronic clinical data registry records from 2000 to 2018 were retrospectively analyzed to study the AMR among pneumococcal isolates at JUH. Temporal trend analysis was done using two-tailed linear-by-linear test for association. The total number of unique pneumococcal isolates that were identified was 556, of which 544 isolates had antimicrobial susceptibility testing results. The most frequent specimens were eye (<i>n</i> = 117, 21.0%), bloodstream (<i>n</i> = 93, 16.7%) and sputum (<i>n</i> = 81, 14.6%). Invasive infections represented 23.6% of all unique isolates. The overall susceptibility of <i>S. pneumoniae</i> isolates during the study period to different antimicrobials was: 100% to vancomycin, 97.7% to ceftriaxone, 97.1% to cefotaxime, 94.9% to chloramphenicol, 89.7% to penicillin, 83.8% to levofloxacin, 67.7% to clindamycin and 52.1% to erythromycin. The prevalence of multi-drug resistance (MDR) was 8.6% (95% confidence interval: 6.4–11.5%). Trend analysis showed an increase in the prevalence of non-susceptibility to erythromycin, clindamycin and levofloxacin (<i>p</i> < 0.001). MDR prevalence increased from 1.6% in the first quarter to 14.6% in the fourth quarter (<i>p</i> < 0.001). The incidence of invasive infections declined over the study period (<i>p</i> < 0.001). The increase in the prevalence of AMR and MDR among pneumococcal isolates in Jordan demands judicious use of antimicrobials and regular surveillance of resistance.https://www.mdpi.com/2079-6382/8/2/41<i>Streptococcus pneumoniae</i>meningitisbacteremiaantibioticMiddle EastJordanresistancetrend |
| spellingShingle | Malik Sallam Jumana Abbadi Anas Natsheh Nidaa A. Ababneh Azmi Mahafzah Gülşen Özkaya Şahin Trends in Antimicrobial Drug Resistance of <i>Streptococcus pneumoniae</i> Isolates at Jordan University Hospital (2000–2018) Antibiotics <i>Streptococcus pneumoniae</i> meningitis bacteremia antibiotic Middle East Jordan resistance trend |
| title | Trends in Antimicrobial Drug Resistance of <i>Streptococcus pneumoniae</i> Isolates at Jordan University Hospital (2000–2018) |
| title_full | Trends in Antimicrobial Drug Resistance of <i>Streptococcus pneumoniae</i> Isolates at Jordan University Hospital (2000–2018) |
| title_fullStr | Trends in Antimicrobial Drug Resistance of <i>Streptococcus pneumoniae</i> Isolates at Jordan University Hospital (2000–2018) |
| title_full_unstemmed | Trends in Antimicrobial Drug Resistance of <i>Streptococcus pneumoniae</i> Isolates at Jordan University Hospital (2000–2018) |
| title_short | Trends in Antimicrobial Drug Resistance of <i>Streptococcus pneumoniae</i> Isolates at Jordan University Hospital (2000–2018) |
| title_sort | trends in antimicrobial drug resistance of i streptococcus pneumoniae i isolates at jordan university hospital 2000 2018 |
| topic | <i>Streptococcus pneumoniae</i> meningitis bacteremia antibiotic Middle East Jordan resistance trend |
| url | https://www.mdpi.com/2079-6382/8/2/41 |
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