The Promise of Automated Home-Cage Monitoring in Improving Translational Utility of Psychiatric Research in Rodents
Large number of promising preclinical psychiatric studies in rodents later fail in clinical trials, raising concerns about the efficacy of this approach to generate novel pharmacological interventions. In this mini-review we argue that over-reliance on behavioral tests that are brief and highly sens...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2020-12-01
|
| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2020.618593/full |
| _version_ | 1818605749204418560 |
|---|---|
| author | Alfred Mingrone Ayal Kaffman Arie Kaffman |
| author_facet | Alfred Mingrone Ayal Kaffman Arie Kaffman |
| author_sort | Alfred Mingrone |
| collection | DOAJ |
| description | Large number of promising preclinical psychiatric studies in rodents later fail in clinical trials, raising concerns about the efficacy of this approach to generate novel pharmacological interventions. In this mini-review we argue that over-reliance on behavioral tests that are brief and highly sensitive to external factors play a critical role in this failure and propose that automated home-cage monitoring offers several advantages that will increase the translational utility of preclinical psychiatric research in rodents. We describe three of the most commonly used approaches for automated home cage monitoring in rodents [e.g., operant wall systems (OWS), computerized visual systems (CVS), and automatic motion sensors (AMS)] and review several commercially available systems that integrate the different approaches. Specific examples that demonstrate the advantages of automated home-cage monitoring over traditional tests of anxiety, depression, cognition, and addiction-like behaviors are highlighted. We conclude with recommendations on how to further expand this promising line of preclinical research. |
| first_indexed | 2024-12-16T13:59:54Z |
| format | Article |
| id | doaj.art-c7d2bc9212de4e24802b79c4b118f146 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-16T13:59:54Z |
| publishDate | 2020-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-c7d2bc9212de4e24802b79c4b118f1462022-12-21T22:29:06ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2020-12-011410.3389/fnins.2020.618593618593The Promise of Automated Home-Cage Monitoring in Improving Translational Utility of Psychiatric Research in RodentsAlfred Mingrone0Ayal Kaffman1Arie Kaffman2Department of Psychology, Southern Connecticut State University, New Haven, CT, United StatesDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, United StatesDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, United StatesLarge number of promising preclinical psychiatric studies in rodents later fail in clinical trials, raising concerns about the efficacy of this approach to generate novel pharmacological interventions. In this mini-review we argue that over-reliance on behavioral tests that are brief and highly sensitive to external factors play a critical role in this failure and propose that automated home-cage monitoring offers several advantages that will increase the translational utility of preclinical psychiatric research in rodents. We describe three of the most commonly used approaches for automated home cage monitoring in rodents [e.g., operant wall systems (OWS), computerized visual systems (CVS), and automatic motion sensors (AMS)] and review several commercially available systems that integrate the different approaches. Specific examples that demonstrate the advantages of automated home-cage monitoring over traditional tests of anxiety, depression, cognition, and addiction-like behaviors are highlighted. We conclude with recommendations on how to further expand this promising line of preclinical research.https://www.frontiersin.org/articles/10.3389/fnins.2020.618593/fullautomated home cage monitoringrodentstranslational researchpsychiatryIntellicage systemPhenoTyper |
| spellingShingle | Alfred Mingrone Ayal Kaffman Arie Kaffman The Promise of Automated Home-Cage Monitoring in Improving Translational Utility of Psychiatric Research in Rodents Frontiers in Neuroscience automated home cage monitoring rodents translational research psychiatry Intellicage system PhenoTyper |
| title | The Promise of Automated Home-Cage Monitoring in Improving Translational Utility of Psychiatric Research in Rodents |
| title_full | The Promise of Automated Home-Cage Monitoring in Improving Translational Utility of Psychiatric Research in Rodents |
| title_fullStr | The Promise of Automated Home-Cage Monitoring in Improving Translational Utility of Psychiatric Research in Rodents |
| title_full_unstemmed | The Promise of Automated Home-Cage Monitoring in Improving Translational Utility of Psychiatric Research in Rodents |
| title_short | The Promise of Automated Home-Cage Monitoring in Improving Translational Utility of Psychiatric Research in Rodents |
| title_sort | promise of automated home cage monitoring in improving translational utility of psychiatric research in rodents |
| topic | automated home cage monitoring rodents translational research psychiatry Intellicage system PhenoTyper |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2020.618593/full |
| work_keys_str_mv | AT alfredmingrone thepromiseofautomatedhomecagemonitoringinimprovingtranslationalutilityofpsychiatricresearchinrodents AT ayalkaffman thepromiseofautomatedhomecagemonitoringinimprovingtranslationalutilityofpsychiatricresearchinrodents AT ariekaffman thepromiseofautomatedhomecagemonitoringinimprovingtranslationalutilityofpsychiatricresearchinrodents AT alfredmingrone promiseofautomatedhomecagemonitoringinimprovingtranslationalutilityofpsychiatricresearchinrodents AT ayalkaffman promiseofautomatedhomecagemonitoringinimprovingtranslationalutilityofpsychiatricresearchinrodents AT ariekaffman promiseofautomatedhomecagemonitoringinimprovingtranslationalutilityofpsychiatricresearchinrodents |