Bamboo-shaving polysaccharide protects against high-diet induced obesity and modulates the gut microbiota of mice
Increasing evidence has shown that gut microbiota plays a critical role in regulating pathogenesis of low-grade inflammation and obesity. Bamboo-shaving polysaccharide (BSP, purity: 80–85%, Mw ≈ 10,000 g/mol) is well known for its immunomodulatory capacity. However, no study has previously investiga...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2018-10-01
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| Series: | Journal of Functional Foods |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464618304365 |
| _version_ | 1819320486962659328 |
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| author | Yufeng Chen Lu Jin Yunhong Li Guobin Xia Chun Chen Ying Zhang |
| author_facet | Yufeng Chen Lu Jin Yunhong Li Guobin Xia Chun Chen Ying Zhang |
| author_sort | Yufeng Chen |
| collection | DOAJ |
| description | Increasing evidence has shown that gut microbiota plays a critical role in regulating pathogenesis of low-grade inflammation and obesity. Bamboo-shaving polysaccharide (BSP, purity: 80–85%, Mw ≈ 10,000 g/mol) is well known for its immunomodulatory capacity. However, no study has previously investigated the anti-obesity activity of BSP. After high fat diet-fed mice were treated with BSP for 8 weeks, we showed that BSP not only improved community richness and diversity of gut microbiota, but also regulated the composition of gut microbiota. Specifically, mice treated with BSP showed lower ratio of Firmicutes/Bacteroidetes, lower relative abundance of harmful bacteria (Enterobacter and Desulfovibrio) and higher relative abundance of beneficial bacteria (Akkermansia muciniphila and Lactobacillus). Moreover, BSP meliorated intestinal barrier integrity, reduced low-grade inflammation, improved lipid metabolism and ameliorated insulin resistance in obese mice. Our results indicated that BSP could be exploited as prebiotic to protect against obesity and insulin resistance in obese individuals. |
| first_indexed | 2024-12-24T11:20:21Z |
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| id | doaj.art-c7d36dc711f742ef8cd7d038a51e23cf |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-24T11:20:21Z |
| publishDate | 2018-10-01 |
| publisher | Elsevier |
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| series | Journal of Functional Foods |
| spelling | doaj.art-c7d36dc711f742ef8cd7d038a51e23cf2022-12-21T16:58:16ZengElsevierJournal of Functional Foods1756-46462018-10-01492031Bamboo-shaving polysaccharide protects against high-diet induced obesity and modulates the gut microbiota of miceYufeng Chen0Lu Jin1Yunhong Li2Guobin Xia3Chun Chen4Ying Zhang5Department of Food Science and Nutrition, School of Biosystems Engineering and Food Science, Zhejiang Key Laboratory for Agro-Food Processing, Zhejiang Engineering Center for Food Technology and Equipment, Zhejiang University, Hangzhou 310058, ChinaSchool of Medicine, Zhejiang University, Hangzhou 310058, ChinaDepartment of Food Science and Nutrition, School of Biosystems Engineering and Food Science, Zhejiang Key Laboratory for Agro-Food Processing, Zhejiang Engineering Center for Food Technology and Equipment, Zhejiang University, Hangzhou 310058, ChinaChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USADepartment of Food Science and Nutrition, School of Biosystems Engineering and Food Science, Zhejiang Key Laboratory for Agro-Food Processing, Zhejiang Engineering Center for Food Technology and Equipment, Zhejiang University, Hangzhou 310058, China; Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, GA 30322, USADepartment of Food Science and Nutrition, School of Biosystems Engineering and Food Science, Zhejiang Key Laboratory for Agro-Food Processing, Zhejiang Engineering Center for Food Technology and Equipment, Zhejiang University, Hangzhou 310058, China; Corresponding author at: College of Biosystems Engineering and Food Science, Zhejiang University, 866 Yuhangtang Road, Xihu District, Hangzhou 310058, China.Increasing evidence has shown that gut microbiota plays a critical role in regulating pathogenesis of low-grade inflammation and obesity. Bamboo-shaving polysaccharide (BSP, purity: 80–85%, Mw ≈ 10,000 g/mol) is well known for its immunomodulatory capacity. However, no study has previously investigated the anti-obesity activity of BSP. After high fat diet-fed mice were treated with BSP for 8 weeks, we showed that BSP not only improved community richness and diversity of gut microbiota, but also regulated the composition of gut microbiota. Specifically, mice treated with BSP showed lower ratio of Firmicutes/Bacteroidetes, lower relative abundance of harmful bacteria (Enterobacter and Desulfovibrio) and higher relative abundance of beneficial bacteria (Akkermansia muciniphila and Lactobacillus). Moreover, BSP meliorated intestinal barrier integrity, reduced low-grade inflammation, improved lipid metabolism and ameliorated insulin resistance in obese mice. Our results indicated that BSP could be exploited as prebiotic to protect against obesity and insulin resistance in obese individuals.http://www.sciencedirect.com/science/article/pii/S1756464618304365Bamboo-shaving polysaccharide (BSP)PrebioticGut microbiotaInflammationObesityInsulin resistance |
| spellingShingle | Yufeng Chen Lu Jin Yunhong Li Guobin Xia Chun Chen Ying Zhang Bamboo-shaving polysaccharide protects against high-diet induced obesity and modulates the gut microbiota of mice Journal of Functional Foods Bamboo-shaving polysaccharide (BSP) Prebiotic Gut microbiota Inflammation Obesity Insulin resistance |
| title | Bamboo-shaving polysaccharide protects against high-diet induced obesity and modulates the gut microbiota of mice |
| title_full | Bamboo-shaving polysaccharide protects against high-diet induced obesity and modulates the gut microbiota of mice |
| title_fullStr | Bamboo-shaving polysaccharide protects against high-diet induced obesity and modulates the gut microbiota of mice |
| title_full_unstemmed | Bamboo-shaving polysaccharide protects against high-diet induced obesity and modulates the gut microbiota of mice |
| title_short | Bamboo-shaving polysaccharide protects against high-diet induced obesity and modulates the gut microbiota of mice |
| title_sort | bamboo shaving polysaccharide protects against high diet induced obesity and modulates the gut microbiota of mice |
| topic | Bamboo-shaving polysaccharide (BSP) Prebiotic Gut microbiota Inflammation Obesity Insulin resistance |
| url | http://www.sciencedirect.com/science/article/pii/S1756464618304365 |
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