Protocol for remapping of place cells in disease mouse models
Summary: Hippocampal place cells and entorhinal grid cells exhibit distinct spike patterns in different environments called “remapping,” and we have recently shown that remapping of place cells becomes disrupted in a mouse model of Alzheimer's disease. Here, we describe our protocol for investi...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2021-09-01
|
| Series: | STAR Protocols |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666166721004652 |
| _version_ | 1818729198953431040 |
|---|---|
| author | Heechul Jun Jasmine Chavez Allen Bramian Kei M. Igarashi |
| author_facet | Heechul Jun Jasmine Chavez Allen Bramian Kei M. Igarashi |
| author_sort | Heechul Jun |
| collection | DOAJ |
| description | Summary: Hippocampal place cells and entorhinal grid cells exhibit distinct spike patterns in different environments called “remapping,” and we have recently shown that remapping of place cells becomes disrupted in a mouse model of Alzheimer's disease. Here, we describe our protocol for investigating remapping of place cells and grid cells using a custom-made electrophysiology device, with detailed descriptions and problem-solving tips for the construction and implantation of the recording device. We also provide steps for behavioral training, recording, and data analysis.For complete details on the use and execution of this protocol, please refer to Jun et al. (2020). |
| first_indexed | 2024-12-17T22:42:05Z |
| format | Article |
| id | doaj.art-c7d383df77af4f3685e69b69fad4338f |
| institution | Directory Open Access Journal |
| issn | 2666-1667 |
| language | English |
| last_indexed | 2024-12-17T22:42:05Z |
| publishDate | 2021-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | STAR Protocols |
| spelling | doaj.art-c7d383df77af4f3685e69b69fad4338f2022-12-21T21:29:54ZengElsevierSTAR Protocols2666-16672021-09-0123100759Protocol for remapping of place cells in disease mouse modelsHeechul Jun0Jasmine Chavez1Allen Bramian2Kei M. Igarashi3Department of Anatomy and Neurobiology, School of Medicine, University of California, Irvine, CA 92697, USA; Corresponding authorDepartment of Anatomy and Neurobiology, School of Medicine, University of California, Irvine, CA 92697, USADepartment of Anatomy and Neurobiology, School of Medicine, University of California, Irvine, CA 92697, USADepartment of Anatomy and Neurobiology, School of Medicine, University of California, Irvine, CA 92697, USA; Corresponding authorSummary: Hippocampal place cells and entorhinal grid cells exhibit distinct spike patterns in different environments called “remapping,” and we have recently shown that remapping of place cells becomes disrupted in a mouse model of Alzheimer's disease. Here, we describe our protocol for investigating remapping of place cells and grid cells using a custom-made electrophysiology device, with detailed descriptions and problem-solving tips for the construction and implantation of the recording device. We also provide steps for behavioral training, recording, and data analysis.For complete details on the use and execution of this protocol, please refer to Jun et al. (2020).http://www.sciencedirect.com/science/article/pii/S2666166721004652Model OrganismsNeuroscienceBehavior |
| spellingShingle | Heechul Jun Jasmine Chavez Allen Bramian Kei M. Igarashi Protocol for remapping of place cells in disease mouse models STAR Protocols Model Organisms Neuroscience Behavior |
| title | Protocol for remapping of place cells in disease mouse models |
| title_full | Protocol for remapping of place cells in disease mouse models |
| title_fullStr | Protocol for remapping of place cells in disease mouse models |
| title_full_unstemmed | Protocol for remapping of place cells in disease mouse models |
| title_short | Protocol for remapping of place cells in disease mouse models |
| title_sort | protocol for remapping of place cells in disease mouse models |
| topic | Model Organisms Neuroscience Behavior |
| url | http://www.sciencedirect.com/science/article/pii/S2666166721004652 |
| work_keys_str_mv | AT heechuljun protocolforremappingofplacecellsindiseasemousemodels AT jasminechavez protocolforremappingofplacecellsindiseasemousemodels AT allenbramian protocolforremappingofplacecellsindiseasemousemodels AT keimigarashi protocolforremappingofplacecellsindiseasemousemodels |