<i>Bifidobacterium</i> Species Colonization in Infancy: A Global Cross-Sectional Comparison by Population History of Breastfeeding
<i>Bifidobacterium</i> species are beneficial and dominant members of the breastfed infant gut microbiome; however, their health benefits are partially species-dependent. Here, we characterize the species and subspecies of <i>Bifidobacterium</i> in breastfed infants around th...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/7/1423 |
| _version_ | 1797438182945456128 |
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| author | Diana H. Taft Zachery T. Lewis Nhu Nguyen Steve Ho Chad Masarweh Vanessa Dunne-Castagna Daniel J. Tancredi M. Nazmul Huda Charles B. Stephensen Katie Hinde Erika von Mutius Pirkka V. Kirjavainen Jean-Charles Dalphin Roger Lauener Josef Riedler Jennifer T. Smilowitz J. Bruce German Ardythe L. Morrow David A. Mills |
| author_facet | Diana H. Taft Zachery T. Lewis Nhu Nguyen Steve Ho Chad Masarweh Vanessa Dunne-Castagna Daniel J. Tancredi M. Nazmul Huda Charles B. Stephensen Katie Hinde Erika von Mutius Pirkka V. Kirjavainen Jean-Charles Dalphin Roger Lauener Josef Riedler Jennifer T. Smilowitz J. Bruce German Ardythe L. Morrow David A. Mills |
| author_sort | Diana H. Taft |
| collection | DOAJ |
| description | <i>Bifidobacterium</i> species are beneficial and dominant members of the breastfed infant gut microbiome; however, their health benefits are partially species-dependent. Here, we characterize the species and subspecies of <i>Bifidobacterium</i> in breastfed infants around the world to consider the potential impact of a historic dietary shift on the disappearance of <i>B. longum</i> subsp. <i>infantis</i> in some populations. Across populations, three distinct patterns of <i>Bifidobacterium</i> colonization emerged: (1) The dominance of <i>Bifidobacterium longum</i> subspecies <i>infantis</i>, (2) prevalent <i>Bifidobacterium</i> of multiple species, and (3) the frequent absence of any <i>Bifidobacterium.</i> These patterns appear related to a country’s history of breastfeeding, with infants in countries with historically high rates of long-duration breastfeeding more likely to be colonized by <i>B. longum</i> subspecies <i>infantis</i> compared with infants in countries with histories of shorter-duration breastfeeding. In addition, the timing of infant colonization with <i>B. longum</i> subsp. <i>infantis</i> is consistent with horizontal transmission of this subspecies, rather than the vertical transmission previously reported for other <i>Bifidobacterium</i> species. These findings highlight the need to consider historical and cultural influences on the prevalence of gut commensals and the need to understand epidemiological transmission patterns of <i>Bifidobacterium</i> and other major commensals. |
| first_indexed | 2024-03-09T11:32:58Z |
| format | Article |
| id | doaj.art-c7d4251870784d5cbef2954b9b870ef3 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T11:32:58Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-c7d4251870784d5cbef2954b9b870ef32023-11-30T23:48:02ZengMDPI AGNutrients2072-66432022-03-01147142310.3390/nu14071423<i>Bifidobacterium</i> Species Colonization in Infancy: A Global Cross-Sectional Comparison by Population History of BreastfeedingDiana H. Taft0Zachery T. Lewis1Nhu Nguyen2Steve Ho3Chad Masarweh4Vanessa Dunne-Castagna5Daniel J. Tancredi6M. Nazmul Huda7Charles B. Stephensen8Katie Hinde9Erika von Mutius10Pirkka V. Kirjavainen11Jean-Charles Dalphin12Roger Lauener13Josef Riedler14Jennifer T. Smilowitz15J. Bruce German16Ardythe L. Morrow17David A. Mills18Department of Food Science and Technology, University of California Davis, Davis, CA 95616, USADepartment of Food Science and Technology, University of California Davis, Davis, CA 95616, USADepartment of Food Science and Technology, University of California Davis, Davis, CA 95616, USADepartment of Food Science and Technology, University of California Davis, Davis, CA 95616, USADepartment of Food Science and Technology, University of California Davis, Davis, CA 95616, USADepartment of Food Science and Technology, University of California Davis, Davis, CA 95616, USADepartment of Pediatrics, University of California Davis School of Medicine, Sacramento, CA 95817, USAUS Department of Agriculture, Western Human Nutrition Research Center, Davis, CA 95616, USAUS Department of Agriculture, Western Human Nutrition Research Center, Davis, CA 95616, USACenter for Evolution and Medicine, School of Human Evolution and Social Change, Arizona State University, Tempe, AZ 85281, USADr. von Hauner Children’s Hospital, Ludwig Maximilian University, 80337 Munich, GermanyEnvironment Health Unit, National Institute for Health and Welfare, 70210 Kuopio, FinlandDepartment of Respiratory Disease, UMR/CNRS 6249 Chrono-Environment, University Hospital of Besançon, F-25000 Besançon, FranceChristine Kühne-Center for Allergy Research and Education, 7265 Davos, SwitzerlandChildren’s Hospital Schwarzach, 5620 Schwarzach, AustriaDepartment of Food Science and Technology, University of California Davis, Davis, CA 95616, USADepartment of Food Science and Technology, University of California Davis, Davis, CA 95616, USADepartment of Environmental and Public Health Sciences, University of Cincinnati, Cincinnati, OH 45221, USADepartment of Food Science and Technology, University of California Davis, Davis, CA 95616, USA<i>Bifidobacterium</i> species are beneficial and dominant members of the breastfed infant gut microbiome; however, their health benefits are partially species-dependent. Here, we characterize the species and subspecies of <i>Bifidobacterium</i> in breastfed infants around the world to consider the potential impact of a historic dietary shift on the disappearance of <i>B. longum</i> subsp. <i>infantis</i> in some populations. Across populations, three distinct patterns of <i>Bifidobacterium</i> colonization emerged: (1) The dominance of <i>Bifidobacterium longum</i> subspecies <i>infantis</i>, (2) prevalent <i>Bifidobacterium</i> of multiple species, and (3) the frequent absence of any <i>Bifidobacterium.</i> These patterns appear related to a country’s history of breastfeeding, with infants in countries with historically high rates of long-duration breastfeeding more likely to be colonized by <i>B. longum</i> subspecies <i>infantis</i> compared with infants in countries with histories of shorter-duration breastfeeding. In addition, the timing of infant colonization with <i>B. longum</i> subsp. <i>infantis</i> is consistent with horizontal transmission of this subspecies, rather than the vertical transmission previously reported for other <i>Bifidobacterium</i> species. These findings highlight the need to consider historical and cultural influences on the prevalence of gut commensals and the need to understand epidemiological transmission patterns of <i>Bifidobacterium</i> and other major commensals.https://www.mdpi.com/2072-6643/14/7/1423breastfeeding<i>Bifidobacterium</i>microbial extinctioninfants |
| spellingShingle | Diana H. Taft Zachery T. Lewis Nhu Nguyen Steve Ho Chad Masarweh Vanessa Dunne-Castagna Daniel J. Tancredi M. Nazmul Huda Charles B. Stephensen Katie Hinde Erika von Mutius Pirkka V. Kirjavainen Jean-Charles Dalphin Roger Lauener Josef Riedler Jennifer T. Smilowitz J. Bruce German Ardythe L. Morrow David A. Mills <i>Bifidobacterium</i> Species Colonization in Infancy: A Global Cross-Sectional Comparison by Population History of Breastfeeding Nutrients breastfeeding <i>Bifidobacterium</i> microbial extinction infants |
| title | <i>Bifidobacterium</i> Species Colonization in Infancy: A Global Cross-Sectional Comparison by Population History of Breastfeeding |
| title_full | <i>Bifidobacterium</i> Species Colonization in Infancy: A Global Cross-Sectional Comparison by Population History of Breastfeeding |
| title_fullStr | <i>Bifidobacterium</i> Species Colonization in Infancy: A Global Cross-Sectional Comparison by Population History of Breastfeeding |
| title_full_unstemmed | <i>Bifidobacterium</i> Species Colonization in Infancy: A Global Cross-Sectional Comparison by Population History of Breastfeeding |
| title_short | <i>Bifidobacterium</i> Species Colonization in Infancy: A Global Cross-Sectional Comparison by Population History of Breastfeeding |
| title_sort | i bifidobacterium i species colonization in infancy a global cross sectional comparison by population history of breastfeeding |
| topic | breastfeeding <i>Bifidobacterium</i> microbial extinction infants |
| url | https://www.mdpi.com/2072-6643/14/7/1423 |
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