Decrypting the circular RNAs does a favor for us: Understanding, diagnosing and treating diabetes mellitus and its complications
Circular RNAs (circRNAs), a novel type of single-stranded noncoding RNAs with a covalently closed loop structure, are generated in a circular conformation via non-canonical splicing or back-splicing events. Functionally, circRNAs have been elucidated to soak up microRNAs (miRNAs) and RNA binding pro...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332223015421 |
| _version_ | 1797630633216835584 |
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| author | Zi Li Yuanyuan Ren Ziwei Lv Man Li Yujia Li Xiaobin Fan Yuyan Xiong Lu Qian |
| author_facet | Zi Li Yuanyuan Ren Ziwei Lv Man Li Yujia Li Xiaobin Fan Yuyan Xiong Lu Qian |
| author_sort | Zi Li |
| collection | DOAJ |
| description | Circular RNAs (circRNAs), a novel type of single-stranded noncoding RNAs with a covalently closed loop structure, are generated in a circular conformation via non-canonical splicing or back-splicing events. Functionally, circRNAs have been elucidated to soak up microRNAs (miRNAs) and RNA binding proteins (RBPs), serve as protein scaffolds, maintain mRNA stability, and regulate gene transcription and translation. Notably, circRNAs are strongly implicated in the regulation of β-cell functions, insulin resistance, adipocyte functions, inflammation as well as oxidative stress via acting as miRNA sponges and RBP sponges. Basic and clinical studies have demonstrated that aberrant alterations of circRNAs expressions are strongly associated with the initiation and progression of diabetes mellitus (DM) and its complications. Here in this review, we present a summary of the biogenesis, transportation, degradation and functions of circRNAs, and highlight the recent findings on circRNAs and their action mechanisms in DM and its complications. Overall, this review should contribute greatly to our understanding of circRNAs in DM pathogenesis, offering insights into the further perspectives of circRNAs for DM diagnosis and therapy. |
| first_indexed | 2024-03-11T11:10:55Z |
| format | Article |
| id | doaj.art-c7d5a6ff1a4b46a8970785128663f331 |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-03-11T11:10:55Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-c7d5a6ff1a4b46a8970785128663f3312023-11-12T04:39:09ZengElsevierBiomedicine & Pharmacotherapy0753-33222023-12-01168115744Decrypting the circular RNAs does a favor for us: Understanding, diagnosing and treating diabetes mellitus and its complicationsZi Li0Yuanyuan Ren1Ziwei Lv2Man Li3Yujia Li4Xiaobin Fan5Yuyan Xiong6Lu Qian7Xi’an Key Laboratory of Cardiovascular and Cerebrovascular Diseases, Xi’an No.3 Hospital, the Affiliated Hospital of Northwest University, Xi’an, Shaanxi, PR China; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education. Faculty of Life Sciences and Medicine, Northwest University, Xi'an, PR ChinaXi’an Key Laboratory of Cardiovascular and Cerebrovascular Diseases, Xi’an No.3 Hospital, the Affiliated Hospital of Northwest University, Xi’an, Shaanxi, PR China; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education. Faculty of Life Sciences and Medicine, Northwest University, Xi'an, PR ChinaXi’an Key Laboratory of Cardiovascular and Cerebrovascular Diseases, Xi’an No.3 Hospital, the Affiliated Hospital of Northwest University, Xi’an, Shaanxi, PR China; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education. Faculty of Life Sciences and Medicine, Northwest University, Xi'an, PR ChinaDepartment of Endocrinology, Xi' an No.3 Hospital, the Affiliated Hospital of Northwest University, Xi'an, Shaanxi, PR ChinaDepartment of Endocrinology, Xi' an No.3 Hospital, the Affiliated Hospital of Northwest University, Xi'an, Shaanxi, PR ChinaDepartment of Obstetrics and Gynecology, Xi' an No.3 Hospital, the Affiliated Hospital of Northwest University, Xi'an, Shaanxi, PR ChinaXi’an Key Laboratory of Cardiovascular and Cerebrovascular Diseases, Xi’an No.3 Hospital, the Affiliated Hospital of Northwest University, Xi’an, Shaanxi, PR China; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education. Faculty of Life Sciences and Medicine, Northwest University, Xi'an, PR China; Correspondence to: Faculty of Life Sciences and Medicine, Northwest University, 229 Taibai North Road, Xi’an 710069, PR China.Xi’an Key Laboratory of Cardiovascular and Cerebrovascular Diseases, Xi’an No.3 Hospital, the Affiliated Hospital of Northwest University, Xi’an, Shaanxi, PR China; Department of Endocrinology, Xi' an No.3 Hospital, the Affiliated Hospital of Northwest University, Xi'an, Shaanxi, PR China; Correspondence to: Department of Endocrinology, Xi' an No.3 Hospital, the Affiliated Hospital of Northwest University, 10 Fengcheng Three Road, Xi'an, Shaanxi 710018, PR China.Circular RNAs (circRNAs), a novel type of single-stranded noncoding RNAs with a covalently closed loop structure, are generated in a circular conformation via non-canonical splicing or back-splicing events. Functionally, circRNAs have been elucidated to soak up microRNAs (miRNAs) and RNA binding proteins (RBPs), serve as protein scaffolds, maintain mRNA stability, and regulate gene transcription and translation. Notably, circRNAs are strongly implicated in the regulation of β-cell functions, insulin resistance, adipocyte functions, inflammation as well as oxidative stress via acting as miRNA sponges and RBP sponges. Basic and clinical studies have demonstrated that aberrant alterations of circRNAs expressions are strongly associated with the initiation and progression of diabetes mellitus (DM) and its complications. Here in this review, we present a summary of the biogenesis, transportation, degradation and functions of circRNAs, and highlight the recent findings on circRNAs and their action mechanisms in DM and its complications. Overall, this review should contribute greatly to our understanding of circRNAs in DM pathogenesis, offering insights into the further perspectives of circRNAs for DM diagnosis and therapy.http://www.sciencedirect.com/science/article/pii/S0753332223015421CircRNAsDiabetes mellitusDiabetes complicationsBiomarker |
| spellingShingle | Zi Li Yuanyuan Ren Ziwei Lv Man Li Yujia Li Xiaobin Fan Yuyan Xiong Lu Qian Decrypting the circular RNAs does a favor for us: Understanding, diagnosing and treating diabetes mellitus and its complications Biomedicine & Pharmacotherapy CircRNAs Diabetes mellitus Diabetes complications Biomarker |
| title | Decrypting the circular RNAs does a favor for us: Understanding, diagnosing and treating diabetes mellitus and its complications |
| title_full | Decrypting the circular RNAs does a favor for us: Understanding, diagnosing and treating diabetes mellitus and its complications |
| title_fullStr | Decrypting the circular RNAs does a favor for us: Understanding, diagnosing and treating diabetes mellitus and its complications |
| title_full_unstemmed | Decrypting the circular RNAs does a favor for us: Understanding, diagnosing and treating diabetes mellitus and its complications |
| title_short | Decrypting the circular RNAs does a favor for us: Understanding, diagnosing and treating diabetes mellitus and its complications |
| title_sort | decrypting the circular rnas does a favor for us understanding diagnosing and treating diabetes mellitus and its complications |
| topic | CircRNAs Diabetes mellitus Diabetes complications Biomarker |
| url | http://www.sciencedirect.com/science/article/pii/S0753332223015421 |
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