Emerging role of 18F-FDG PET/CT in Castleman disease: a review
Abstract Castleman disease (CD) describes a group of rare hematologic conditions involving lymphadenopathy with characteristic histopathology and a spectrum of clinical abnormalities. CD is divided into localized or unicentric CD (UCD) and multicentric CD (MCD) by imaging. MCD is further divided bas...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2021-03-01
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| Series: | Insights into Imaging |
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| Online Access: | https://doi.org/10.1186/s13244-021-00963-1 |
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| author | Benjamin Koa Austin J. Borja Mahmoud Aly Sayuri Padmanabhan Joseph Tran Vincent Zhang Chaitanya Rojulpote Sheila K. Pierson Mark-Avery Tamakloe Johnson S. Khor Thomas J. Werner David C. Fajgenbaum Abass Alavi Mona-Elisabeth Revheim |
| author_facet | Benjamin Koa Austin J. Borja Mahmoud Aly Sayuri Padmanabhan Joseph Tran Vincent Zhang Chaitanya Rojulpote Sheila K. Pierson Mark-Avery Tamakloe Johnson S. Khor Thomas J. Werner David C. Fajgenbaum Abass Alavi Mona-Elisabeth Revheim |
| author_sort | Benjamin Koa |
| collection | DOAJ |
| description | Abstract Castleman disease (CD) describes a group of rare hematologic conditions involving lymphadenopathy with characteristic histopathology and a spectrum of clinical abnormalities. CD is divided into localized or unicentric CD (UCD) and multicentric CD (MCD) by imaging. MCD is further divided based on etiological driver into human herpesvirus-8-associated MCD, POEMS-associated MCD, and idiopathic MCD. There is notable heterogeneity across MCD, but increased level of pro-inflammatory cytokines, particularly interleukin-6, is an established disease driver in a portion of patients. FDG-PET/CT can help determine UCD versus MCD, evaluate for neoplastic conditions that can mimic MCD clinico-pathologically, and monitor therapy responses. CD requires more robust characterization, earlier diagnosis, and an accurate tool for both monitoring and treatment response evaluation; FDG-PET/CT is particularly suited for this. Moving forward, future prospective studies should further characterize the use of FDG-PET/CT in CD and specifically explore the utility of global disease assessment and dual time point imaging. Trial registration ClinicalTrials.gov, NCT02817997, Registered 29 June 2016, https://clinicaltrials.gov/ct2/show/NCT02817997 |
| first_indexed | 2024-12-14T15:33:49Z |
| format | Article |
| id | doaj.art-c7d6e0a69328431587f81f286f1330fd |
| institution | Directory Open Access Journal |
| issn | 1869-4101 |
| language | English |
| last_indexed | 2024-12-14T15:33:49Z |
| publishDate | 2021-03-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Insights into Imaging |
| spelling | doaj.art-c7d6e0a69328431587f81f286f1330fd2022-12-21T22:55:48ZengSpringerOpenInsights into Imaging1869-41012021-03-0112111110.1186/s13244-021-00963-1Emerging role of 18F-FDG PET/CT in Castleman disease: a reviewBenjamin Koa0Austin J. Borja1Mahmoud Aly2Sayuri Padmanabhan3Joseph Tran4Vincent Zhang5Chaitanya Rojulpote6Sheila K. Pierson7Mark-Avery Tamakloe8Johnson S. Khor9Thomas J. Werner10David C. Fajgenbaum11Abass Alavi12Mona-Elisabeth Revheim13Department of Radiology, University of PennsylvaniaDepartment of Radiology, University of PennsylvaniaDepartment of Radiology, University of PennsylvaniaDepartment of Radiology, University of PennsylvaniaDepartment of Radiology, University of PennsylvaniaDepartment of Radiology, University of PennsylvaniaDepartment of Radiology, University of PennsylvaniaDepartment of Medicine, Division of Translational Medicine and Human Genetics, University of PennsylvaniaDepartment of Medicine, Division of Translational Medicine and Human Genetics, University of PennsylvaniaDepartment of Medicine, Division of Translational Medicine and Human Genetics, University of PennsylvaniaDepartment of Radiology, University of PennsylvaniaDepartment of Medicine, Division of Translational Medicine and Human Genetics, University of PennsylvaniaDepartment of Radiology, University of PennsylvaniaDepartment of Radiology, University of PennsylvaniaAbstract Castleman disease (CD) describes a group of rare hematologic conditions involving lymphadenopathy with characteristic histopathology and a spectrum of clinical abnormalities. CD is divided into localized or unicentric CD (UCD) and multicentric CD (MCD) by imaging. MCD is further divided based on etiological driver into human herpesvirus-8-associated MCD, POEMS-associated MCD, and idiopathic MCD. There is notable heterogeneity across MCD, but increased level of pro-inflammatory cytokines, particularly interleukin-6, is an established disease driver in a portion of patients. FDG-PET/CT can help determine UCD versus MCD, evaluate for neoplastic conditions that can mimic MCD clinico-pathologically, and monitor therapy responses. CD requires more robust characterization, earlier diagnosis, and an accurate tool for both monitoring and treatment response evaluation; FDG-PET/CT is particularly suited for this. Moving forward, future prospective studies should further characterize the use of FDG-PET/CT in CD and specifically explore the utility of global disease assessment and dual time point imaging. Trial registration ClinicalTrials.gov, NCT02817997, Registered 29 June 2016, https://clinicaltrials.gov/ct2/show/NCT02817997https://doi.org/10.1186/s13244-021-00963-1Castleman diseasePositron emission tomography/computed tomographyFluorodeoxyglucose F18Interleukin-6HIV |
| spellingShingle | Benjamin Koa Austin J. Borja Mahmoud Aly Sayuri Padmanabhan Joseph Tran Vincent Zhang Chaitanya Rojulpote Sheila K. Pierson Mark-Avery Tamakloe Johnson S. Khor Thomas J. Werner David C. Fajgenbaum Abass Alavi Mona-Elisabeth Revheim Emerging role of 18F-FDG PET/CT in Castleman disease: a review Insights into Imaging Castleman disease Positron emission tomography/computed tomography Fluorodeoxyglucose F18 Interleukin-6 HIV |
| title | Emerging role of 18F-FDG PET/CT in Castleman disease: a review |
| title_full | Emerging role of 18F-FDG PET/CT in Castleman disease: a review |
| title_fullStr | Emerging role of 18F-FDG PET/CT in Castleman disease: a review |
| title_full_unstemmed | Emerging role of 18F-FDG PET/CT in Castleman disease: a review |
| title_short | Emerging role of 18F-FDG PET/CT in Castleman disease: a review |
| title_sort | emerging role of 18f fdg pet ct in castleman disease a review |
| topic | Castleman disease Positron emission tomography/computed tomography Fluorodeoxyglucose F18 Interleukin-6 HIV |
| url | https://doi.org/10.1186/s13244-021-00963-1 |
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