Mapping sequence structure in the human lateral entorhinal cortex
Remembering event sequences is central to episodic memory and presumably supported by the hippocampal-entorhinal region. We previously demonstrated that the hippocampus maps spatial and temporal distances between events encountered along a route through a virtual city (Deuker et al., 2016), but the...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2019-08-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/45333 |
| _version_ | 1811199467548835840 |
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| author | Jacob LS Bellmund Lorena Deuker Christian F Doeller |
| author_facet | Jacob LS Bellmund Lorena Deuker Christian F Doeller |
| author_sort | Jacob LS Bellmund |
| collection | DOAJ |
| description | Remembering event sequences is central to episodic memory and presumably supported by the hippocampal-entorhinal region. We previously demonstrated that the hippocampus maps spatial and temporal distances between events encountered along a route through a virtual city (Deuker et al., 2016), but the content of entorhinal mnemonic representations remains unclear. Here, we demonstrate that multi-voxel representations in the anterior-lateral entorhinal cortex (alEC) — the human homologue of the rodent lateral entorhinal cortex — specifically reflect the temporal event structure after learning. Holistic representations of the sequence structure related to memory recall and the timeline of events could be reconstructed from entorhinal multi-voxel patterns. Our findings demonstrate representations of temporal structure in the alEC; dovetailing with temporal information carried by population signals in the lateral entorhinal cortex of navigating rodents and alEC activations during temporal memory retrieval. Our results provide novel evidence for the role of the alEC in representing time for episodic memory. |
| first_indexed | 2024-04-12T01:49:49Z |
| format | Article |
| id | doaj.art-c7da16c8ed1f4b7f97aa5068ab6d2c5d |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T01:49:49Z |
| publishDate | 2019-08-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-c7da16c8ed1f4b7f97aa5068ab6d2c5d2022-12-22T03:52:59ZengeLife Sciences Publications LtdeLife2050-084X2019-08-01810.7554/eLife.45333Mapping sequence structure in the human lateral entorhinal cortexJacob LS Bellmund0https://orcid.org/0000-0002-2098-4487Lorena Deuker1https://orcid.org/0000-0002-4939-5862Christian F Doeller2https://orcid.org/0000-0003-4120-4600Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany; Kavli Institute for Systems Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway; Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, NetherlandsDepartment of Neuropsychology, Institute of Cognitive Neuroscience, Faculty of Psychology, Ruhr University Bochum, Bochum, GermanyMax Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany; Kavli Institute for Systems Neuroscience, Norwegian University of Science and Technology, Trondheim, NorwayRemembering event sequences is central to episodic memory and presumably supported by the hippocampal-entorhinal region. We previously demonstrated that the hippocampus maps spatial and temporal distances between events encountered along a route through a virtual city (Deuker et al., 2016), but the content of entorhinal mnemonic representations remains unclear. Here, we demonstrate that multi-voxel representations in the anterior-lateral entorhinal cortex (alEC) — the human homologue of the rodent lateral entorhinal cortex — specifically reflect the temporal event structure after learning. Holistic representations of the sequence structure related to memory recall and the timeline of events could be reconstructed from entorhinal multi-voxel patterns. Our findings demonstrate representations of temporal structure in the alEC; dovetailing with temporal information carried by population signals in the lateral entorhinal cortex of navigating rodents and alEC activations during temporal memory retrieval. Our results provide novel evidence for the role of the alEC in representing time for episodic memory.https://elifesciences.org/articles/45333episodic memoryentorhinal cortexfMRItimevirtual realitymemory |
| spellingShingle | Jacob LS Bellmund Lorena Deuker Christian F Doeller Mapping sequence structure in the human lateral entorhinal cortex eLife episodic memory entorhinal cortex fMRI time virtual reality memory |
| title | Mapping sequence structure in the human lateral entorhinal cortex |
| title_full | Mapping sequence structure in the human lateral entorhinal cortex |
| title_fullStr | Mapping sequence structure in the human lateral entorhinal cortex |
| title_full_unstemmed | Mapping sequence structure in the human lateral entorhinal cortex |
| title_short | Mapping sequence structure in the human lateral entorhinal cortex |
| title_sort | mapping sequence structure in the human lateral entorhinal cortex |
| topic | episodic memory entorhinal cortex fMRI time virtual reality memory |
| url | https://elifesciences.org/articles/45333 |
| work_keys_str_mv | AT jacoblsbellmund mappingsequencestructureinthehumanlateralentorhinalcortex AT lorenadeuker mappingsequencestructureinthehumanlateralentorhinalcortex AT christianfdoeller mappingsequencestructureinthehumanlateralentorhinalcortex |