Chemotherapy-induced cellular senescence suppresses progression of Notch-driven T-ALL.

Chemotherapy-induced cellular senescence suppresses progression of Notch-driven T-ALL.

T cell acute lymphoblastic leukemia (T-ALL) is a serious hematologic malignancy that occurs in children and young adults. Current therapies include intensive chemotherapy and ionizing radiation that preferentially kill malignant cells. Unfortunately, they are frequently accompanied by unintended neg...

Full description

Bibliographic Details
Main Authors: Ying Zhang, Justin Gundelach, Lonnie D Lindquist, Darren J Baker, Jan van Deursen, Richard J Bram
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0224172

Similar Items

Similar Items