A neurotoxic glycerophosphocholine impacts PtdIns-4, 5-bisphosphate and TORC2 signaling by altering ceramide biosynthesis in yeast.

A neurotoxic glycerophosphocholine impacts PtdIns-4, 5-bisphosphate and TORC2 signaling by altering ceramide biosynthesis in yeast.

Unbiased lipidomic approaches have identified impairments in glycerophosphocholine second messenger metabolism in patients with Alzheimer's disease. Specifically, we have shown that amyloid-β42 signals the intraneuronal accumulation of PC(O-16:0/2:0) which is associated with neurotoxicity. Simi...

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Bibliographic Details
Main Authors: Michael A Kennedy, Kenneth Gable, Karolina Niewola-Staszkowska, Susana Abreu, Anne Johnston, Linda J Harris, Fulvio Reggiori, Robbie Loewith, Teresa Dunn, Steffany A L Bennett, Kristin Baetz
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3900389?pdf=render

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