Application of green synthesized silver nanoparticles in cancer treatment—a critical review
With the breakthrough in advance technologies, researchers are looking to devise novel approaches to control different types of deadly cancers. Progress in medicinal plants research and nanotechnology has drawn scientist’s attention toward green synthesis of metallic nanoparticles by exploiting plan...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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IOP Publishing
2021-01-01
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| Series: | Materials Research Express |
| Subjects: | |
| Online Access: | https://doi.org/10.1088/2053-1591/ac1de3 |
| _version_ | 1827869262368210944 |
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| author | Shazina Jabeen Rahmatullah Qureshi Mehmooda Munazir Muhammad Maqsood Mubashrah Munir Syed Sabir Hussain Shah Bakht Zareen Rahim |
| author_facet | Shazina Jabeen Rahmatullah Qureshi Mehmooda Munazir Muhammad Maqsood Mubashrah Munir Syed Sabir Hussain Shah Bakht Zareen Rahim |
| author_sort | Shazina Jabeen |
| collection | DOAJ |
| description | With the breakthrough in advance technologies, researchers are looking to devise novel approaches to control different types of deadly cancers. Progress in medicinal plants research and nanotechnology has drawn scientist’s attention toward green synthesis of metallic nanoparticles by exploiting plants secondary metabolites owing to its advantage over routinely used physical and chemical synthesis (simple, one step approach to reduce and stabilize bulk silver into silver nanoparticles (AgNPs), cost effectiveness, energy efficient, biocompatibility and therapeutic significance). Owing to control size, shape and functional surface corona, AgNPs hold considerable potentiality for therapeutic applications by opting different mechanistic pathways such as mitochondrial disruption, DNA fragmentation, cell membrane disruption, interruption of cellular signaling pathways, altered enzyme activity and reactive oxygen species (ROS) production leading to apoptosis etc In this review, we discussed the green synthesized AgNPs in the possible cancer treatment by harnessing phytochemicals present in plant extract. In addition, this review also provides recent advances and achievements in utilization of green synthesized AgNPs in cancer treatment and proposes mechanistic action for their anticancer and cytotoxic potential. By understanding the mechanistic action of AgNPs responsible for their therapeutic efficacy will help to devise customized therapies and treatment against cancer as a potential cancer therapeutic tool. |
| first_indexed | 2024-03-12T15:42:28Z |
| format | Article |
| id | doaj.art-c7e3e9625343467db9c170b7fe11fbc0 |
| institution | Directory Open Access Journal |
| issn | 2053-1591 |
| language | English |
| last_indexed | 2024-03-12T15:42:28Z |
| publishDate | 2021-01-01 |
| publisher | IOP Publishing |
| record_format | Article |
| series | Materials Research Express |
| spelling | doaj.art-c7e3e9625343467db9c170b7fe11fbc02023-08-09T15:54:18ZengIOP PublishingMaterials Research Express2053-15912021-01-018909200110.1088/2053-1591/ac1de3Application of green synthesized silver nanoparticles in cancer treatment—a critical reviewShazina Jabeen0https://orcid.org/0000-0002-8533-942XRahmatullah Qureshi1Mehmooda Munazir2https://orcid.org/0000-0002-5905-9440Muhammad Maqsood3Mubashrah Munir4Syed Sabir Hussain Shah5Bakht Zareen Rahim6Department of Botany, Pir Mehr Ali Shah Arid Agriculture University , Rawalpindi, Punjab 46300, PakistanDepartment of Botany, Pir Mehr Ali Shah Arid Agriculture University , Rawalpindi, Punjab 46300, PakistanDepartment of Botany, Government College, Women University , 51040 Sialkot, Punjab, PakistanDepartment of Botany, Pir Mehr Ali Shah Arid Agriculture University , Rawalpindi, Punjab 46300, PakistanDepartment of Botany, University of Animal & Plant Sciences , Ravi Campus, Pattoki, Punjab, PakistanDepartment of Botany, Pir Mehr Ali Shah Arid Agriculture University , Rawalpindi, Punjab 46300, PakistanDepartment of Botany, Baluchistan University , 87500 Quetta, Baluchistan, PakistanWith the breakthrough in advance technologies, researchers are looking to devise novel approaches to control different types of deadly cancers. Progress in medicinal plants research and nanotechnology has drawn scientist’s attention toward green synthesis of metallic nanoparticles by exploiting plants secondary metabolites owing to its advantage over routinely used physical and chemical synthesis (simple, one step approach to reduce and stabilize bulk silver into silver nanoparticles (AgNPs), cost effectiveness, energy efficient, biocompatibility and therapeutic significance). Owing to control size, shape and functional surface corona, AgNPs hold considerable potentiality for therapeutic applications by opting different mechanistic pathways such as mitochondrial disruption, DNA fragmentation, cell membrane disruption, interruption of cellular signaling pathways, altered enzyme activity and reactive oxygen species (ROS) production leading to apoptosis etc In this review, we discussed the green synthesized AgNPs in the possible cancer treatment by harnessing phytochemicals present in plant extract. In addition, this review also provides recent advances and achievements in utilization of green synthesized AgNPs in cancer treatment and proposes mechanistic action for their anticancer and cytotoxic potential. By understanding the mechanistic action of AgNPs responsible for their therapeutic efficacy will help to devise customized therapies and treatment against cancer as a potential cancer therapeutic tool.https://doi.org/10.1088/2053-1591/ac1de3green synthesisnanomedicineanticancerreactive oxygen speciessilver nanoparticlesnanotechnology |
| spellingShingle | Shazina Jabeen Rahmatullah Qureshi Mehmooda Munazir Muhammad Maqsood Mubashrah Munir Syed Sabir Hussain Shah Bakht Zareen Rahim Application of green synthesized silver nanoparticles in cancer treatment—a critical review Materials Research Express green synthesis nanomedicine anticancer reactive oxygen species silver nanoparticles nanotechnology |
| title | Application of green synthesized silver nanoparticles in cancer treatment—a critical review |
| title_full | Application of green synthesized silver nanoparticles in cancer treatment—a critical review |
| title_fullStr | Application of green synthesized silver nanoparticles in cancer treatment—a critical review |
| title_full_unstemmed | Application of green synthesized silver nanoparticles in cancer treatment—a critical review |
| title_short | Application of green synthesized silver nanoparticles in cancer treatment—a critical review |
| title_sort | application of green synthesized silver nanoparticles in cancer treatment a critical review |
| topic | green synthesis nanomedicine anticancer reactive oxygen species silver nanoparticles nanotechnology |
| url | https://doi.org/10.1088/2053-1591/ac1de3 |
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