Mammographic Density Changes over Time and Breast Cancer Risk: A Systematic Review and Meta-Analysis
The aim of this meta-analysis was to evaluate the association between mammographic density changes over time and the risk of breast cancer. We performed a systematic literature review based on the PubMed and ISI Web of Knowledge databases. A meta-analysis was conducted by computing extracted hazard...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/13/19/4805 |
| _version_ | 1797516746463117312 |
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| author | Arezo Mokhtary Andreas Karakatsanis Antonis Valachis |
| author_facet | Arezo Mokhtary Andreas Karakatsanis Antonis Valachis |
| author_sort | Arezo Mokhtary |
| collection | DOAJ |
| description | The aim of this meta-analysis was to evaluate the association between mammographic density changes over time and the risk of breast cancer. We performed a systematic literature review based on the PubMed and ISI Web of Knowledge databases. A meta-analysis was conducted by computing extracted hazard ratios (HRs) and 95% confidence intervals (CIs) for cohort studies or odds ratios (ORs) and 95% confidence interval using inverse variance method. Of the nine studies included, five were cohort studies that used HR as a measurement type for their statistical analysis and four were case–control or cohort studies that used OR as a measurement type. Increased breast density over time in cohort studies was associated with higher breast cancer risk (HR: 1.61; 95% CI: 1.33–1.96) whereas decreased breast density over time was associated with lower breast cancer risk (HR: 0.78; 95% CI: 0.71–0.87). Similarly, increased breast density over time was associated with higher breast cancer risk in studies presented ORs (pooled OR: 1.85; 95% CI: 1.29–2.65). Our findings imply that an increase in breast density over time seems to be linked to an increased risk of breast cancer, whereas a decrease in breast density over time seems to be linked to a lower risk of breast cancer. |
| first_indexed | 2024-03-10T07:05:10Z |
| format | Article |
| id | doaj.art-c7e41bbdee3c4bf4b5cdc6d392926134 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T07:05:10Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-c7e41bbdee3c4bf4b5cdc6d3929261342023-11-22T15:52:37ZengMDPI AGCancers2072-66942021-09-011319480510.3390/cancers13194805Mammographic Density Changes over Time and Breast Cancer Risk: A Systematic Review and Meta-AnalysisArezo Mokhtary0Andreas Karakatsanis1Antonis Valachis2Faculty of Medicine and Health, School of Medical Sciences, Örebro University, 70182 Örebro, SwedenDepartment of Surgical Sciences, Uppsala University, 75185 Uppsala, SwedenDepartment of Oncology, Faculty of Medicine and Health, Örebro University, 70182 Örebro, SwedenThe aim of this meta-analysis was to evaluate the association between mammographic density changes over time and the risk of breast cancer. We performed a systematic literature review based on the PubMed and ISI Web of Knowledge databases. A meta-analysis was conducted by computing extracted hazard ratios (HRs) and 95% confidence intervals (CIs) for cohort studies or odds ratios (ORs) and 95% confidence interval using inverse variance method. Of the nine studies included, five were cohort studies that used HR as a measurement type for their statistical analysis and four were case–control or cohort studies that used OR as a measurement type. Increased breast density over time in cohort studies was associated with higher breast cancer risk (HR: 1.61; 95% CI: 1.33–1.96) whereas decreased breast density over time was associated with lower breast cancer risk (HR: 0.78; 95% CI: 0.71–0.87). Similarly, increased breast density over time was associated with higher breast cancer risk in studies presented ORs (pooled OR: 1.85; 95% CI: 1.29–2.65). Our findings imply that an increase in breast density over time seems to be linked to an increased risk of breast cancer, whereas a decrease in breast density over time seems to be linked to a lower risk of breast cancer.https://www.mdpi.com/2072-6694/13/19/4805breast cancer riskbreast densitymammographymeta-analysis |
| spellingShingle | Arezo Mokhtary Andreas Karakatsanis Antonis Valachis Mammographic Density Changes over Time and Breast Cancer Risk: A Systematic Review and Meta-Analysis Cancers breast cancer risk breast density mammography meta-analysis |
| title | Mammographic Density Changes over Time and Breast Cancer Risk: A Systematic Review and Meta-Analysis |
| title_full | Mammographic Density Changes over Time and Breast Cancer Risk: A Systematic Review and Meta-Analysis |
| title_fullStr | Mammographic Density Changes over Time and Breast Cancer Risk: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Mammographic Density Changes over Time and Breast Cancer Risk: A Systematic Review and Meta-Analysis |
| title_short | Mammographic Density Changes over Time and Breast Cancer Risk: A Systematic Review and Meta-Analysis |
| title_sort | mammographic density changes over time and breast cancer risk a systematic review and meta analysis |
| topic | breast cancer risk breast density mammography meta-analysis |
| url | https://www.mdpi.com/2072-6694/13/19/4805 |
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