The protective effect of <em>Matricaria pubescens</em> extracts against alloxan-induced hyperglycemia in rats
This study aims to investigate the plausible inhibitory capacity of Matricaria pubescens methanolic extract (EMMP) on key diabetes-related enzymes in diabetic rats. A significant increase in the serum and pancreatic α-amylase activity in untreated diabetic rats (Diab) by 61% and 75% respectively pr...
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2022-08-01
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| Series: | Journal of Biological Research |
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| Online Access: | https://pagepressjournals.org/index.php/jbr/article/view/10441 |
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| author | Kherraz Khaled Ghemam Amara Djilani Laoudj Hacen Mahdid Mohmed Chefrour Azedinne |
| author_facet | Kherraz Khaled Ghemam Amara Djilani Laoudj Hacen Mahdid Mohmed Chefrour Azedinne |
| author_sort | Kherraz Khaled |
| collection | DOAJ |
| description |
This study aims to investigate the plausible inhibitory capacity of Matricaria pubescens methanolic extract (EMMP) on key diabetes-related enzymes in diabetic rats. A significant increase in the serum and pancreatic α-amylase activity in untreated diabetic rats (Diab) by 61% and 75% respectively produced a remarkable rise in blood glucose levels of 184% compared with the controls. However, the treatment of diabetic rats with the extract (Diab + EMMP) caused a significant decrease in pancreatic α-amylase activity in the pancreas (15%) and in serum (28%) compared to untreated diabetic rats. Therefore, a considerable reduction in blood sugar level has been observed reaching 28%. A significant decrease was observed in the glycated hemoglobin (HbA1c) level (28%) in rats treated with EMMP compared to untreated diabetics. Furthermore a significant increase in the pancreatic serum lipase activity (59%) compared to the control group, led to a distinguished inhibition (21%) in diabetic rats treated with EMMP. A potent protective action of β-cells was observed in diabetic rats treated with EMMP. However, we observed recovery in body weight in the diabetic rats treated with EMMP.
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| first_indexed | 2024-04-12T07:56:53Z |
| format | Article |
| id | doaj.art-c7e4487038b446e69759120ef137f4be |
| institution | Directory Open Access Journal |
| issn | 1826-8838 2284-0230 |
| language | English |
| last_indexed | 2024-04-12T07:56:53Z |
| publishDate | 2022-08-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Journal of Biological Research |
| spelling | doaj.art-c7e4487038b446e69759120ef137f4be2022-12-22T03:41:28ZengPAGEPress PublicationsJournal of Biological Research1826-88382284-02302022-08-0110.4081/jbr.2022.10441The protective effect of <em>Matricaria pubescens</em> extracts against alloxan-induced hyperglycemia in ratsKherraz Khaled0Ghemam Amara Djilani1Laoudj Hacen2Mahdid Mohmed3Chefrour Azedinne4Laboratory of Ethnobotany and Natural Substances, Ecole Normale Supérieur-KoubaDepartment of Biology, Faculty of Nature and Life Sciences, University Echahid Hammalakhdar El-ouedDepartment of Biology, Faculty of Nature and Life Sciences, University Echahid Hammalakhdar El-ouedLaboratory of Ethnobotany and Natural Substances, Ecole Normale Supérieur-KoubaDepartment of Biology, Faculty of Nature and Life Sciences, University Mohamed-Chérif Messaadia Souk Ahras This study aims to investigate the plausible inhibitory capacity of Matricaria pubescens methanolic extract (EMMP) on key diabetes-related enzymes in diabetic rats. A significant increase in the serum and pancreatic α-amylase activity in untreated diabetic rats (Diab) by 61% and 75% respectively produced a remarkable rise in blood glucose levels of 184% compared with the controls. However, the treatment of diabetic rats with the extract (Diab + EMMP) caused a significant decrease in pancreatic α-amylase activity in the pancreas (15%) and in serum (28%) compared to untreated diabetic rats. Therefore, a considerable reduction in blood sugar level has been observed reaching 28%. A significant decrease was observed in the glycated hemoglobin (HbA1c) level (28%) in rats treated with EMMP compared to untreated diabetics. Furthermore a significant increase in the pancreatic serum lipase activity (59%) compared to the control group, led to a distinguished inhibition (21%) in diabetic rats treated with EMMP. A potent protective action of β-cells was observed in diabetic rats treated with EMMP. However, we observed recovery in body weight in the diabetic rats treated with EMMP. https://pagepressjournals.org/index.php/jbr/article/view/10441EMMPβ-cellsdiabetesHbA1cα-amylase |
| spellingShingle | Kherraz Khaled Ghemam Amara Djilani Laoudj Hacen Mahdid Mohmed Chefrour Azedinne The protective effect of <em>Matricaria pubescens</em> extracts against alloxan-induced hyperglycemia in rats Journal of Biological Research EMMP β-cells diabetes HbA1c α-amylase |
| title | The protective effect of <em>Matricaria pubescens</em> extracts against alloxan-induced hyperglycemia in rats |
| title_full | The protective effect of <em>Matricaria pubescens</em> extracts against alloxan-induced hyperglycemia in rats |
| title_fullStr | The protective effect of <em>Matricaria pubescens</em> extracts against alloxan-induced hyperglycemia in rats |
| title_full_unstemmed | The protective effect of <em>Matricaria pubescens</em> extracts against alloxan-induced hyperglycemia in rats |
| title_short | The protective effect of <em>Matricaria pubescens</em> extracts against alloxan-induced hyperglycemia in rats |
| title_sort | protective effect of em matricaria pubescens em extracts against alloxan induced hyperglycemia in rats |
| topic | EMMP β-cells diabetes HbA1c α-amylase |
| url | https://pagepressjournals.org/index.php/jbr/article/view/10441 |
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