New Insights in the Setting of Transplant Oncology
<i>Background and Objectives</i>: Liver transplantation (LT) is the best strategy for curing several primary and secondary hepatic malignancies. In recent years, growing interest has been observed in the enlargement of the transplant oncology indications. This paper aims to review the mo...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/59/3/568 |
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| author | Silvia Quaresima Fabio Melandro Francesco Giovanardi Kejal Shah Valerio De Peppo Gianluca Mennini Davide Ghinolfi Ashley Limkemann Timothy M. Pawlik Quirino Lai |
| author_facet | Silvia Quaresima Fabio Melandro Francesco Giovanardi Kejal Shah Valerio De Peppo Gianluca Mennini Davide Ghinolfi Ashley Limkemann Timothy M. Pawlik Quirino Lai |
| author_sort | Silvia Quaresima |
| collection | DOAJ |
| description | <i>Background and Objectives</i>: Liver transplantation (LT) is the best strategy for curing several primary and secondary hepatic malignancies. In recent years, growing interest has been observed in the enlargement of the transplant oncology indications. This paper aims to review the most recent developments in the setting of LT oncology, with particular attention to LT for unresectable colorectal liver metastases (CRLM) and cholangiocellular carcinoma (CCA). <i>Materials and Methods</i>: A review of the recently published literature was conducted. <i>Results</i>: Growing evidence exists on the efficacy of LT in curing CRLM and peri-hilar and intrahepatic CCA in well-selected patients when integrating this strategy with (neo)-adjuvant chemotherapy, radiotherapy, or locoregional treatments. <i>Conclusion</i>: For unresectable CCA and CRLM management, several prospective protocols are forthcoming to elucidate LT’s impact relative to alternative therapies. Advances in diagnosis, treatment protocols, and donor-to-recipient matching are needed to better define the oncological indications for transplantation. Prospective, multicenter trials studying these advances and their impact on outcomes are still required. |
| first_indexed | 2024-03-11T06:12:39Z |
| format | Article |
| id | doaj.art-c7e5e42273004555a39a26d13384b1a0 |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-11T06:12:39Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-c7e5e42273004555a39a26d13384b1a02023-11-17T12:32:30ZengMDPI AGMedicina1010-660X1648-91442023-03-0159356810.3390/medicina59030568New Insights in the Setting of Transplant OncologySilvia Quaresima0Fabio Melandro1Francesco Giovanardi2Kejal Shah3Valerio De Peppo4Gianluca Mennini5Davide Ghinolfi6Ashley Limkemann7Timothy M. Pawlik8Quirino Lai9General Surgery and Organ Transplantation Unit, AOU Policlinico Umberto I, Sapienza University of Rome, 00161 Rome, ItalyGeneral Surgery and Organ Transplantation Unit, AOU Policlinico Umberto I, Sapienza University of Rome, 00161 Rome, ItalyGeneral Surgery and Organ Transplantation Unit, AOU Policlinico Umberto I, Sapienza University of Rome, 00161 Rome, ItalyDepartment of Surgery, Division of Surgical Oncology, James Cancer Center, The Ohio State University, Columbus, OH 43210, USAGeneral Surgery and Organ Transplantation Unit, AOU Policlinico Umberto I, Sapienza University of Rome, 00161 Rome, ItalyGeneral Surgery and Organ Transplantation Unit, AOU Policlinico Umberto I, Sapienza University of Rome, 00161 Rome, ItalyHepatobiliary Surgery and Liver Transplantation, University of Pisa Medical School Hospital, 56124 Pisa, ItalyDepartment of Surgery, Division of Surgical Oncology, James Cancer Center, The Ohio State University, Columbus, OH 43210, USADepartment of Surgery, Division of Surgical Oncology, James Cancer Center, The Ohio State University, Columbus, OH 43210, USAGeneral Surgery and Organ Transplantation Unit, AOU Policlinico Umberto I, Sapienza University of Rome, 00161 Rome, Italy<i>Background and Objectives</i>: Liver transplantation (LT) is the best strategy for curing several primary and secondary hepatic malignancies. In recent years, growing interest has been observed in the enlargement of the transplant oncology indications. This paper aims to review the most recent developments in the setting of LT oncology, with particular attention to LT for unresectable colorectal liver metastases (CRLM) and cholangiocellular carcinoma (CCA). <i>Materials and Methods</i>: A review of the recently published literature was conducted. <i>Results</i>: Growing evidence exists on the efficacy of LT in curing CRLM and peri-hilar and intrahepatic CCA in well-selected patients when integrating this strategy with (neo)-adjuvant chemotherapy, radiotherapy, or locoregional treatments. <i>Conclusion</i>: For unresectable CCA and CRLM management, several prospective protocols are forthcoming to elucidate LT’s impact relative to alternative therapies. Advances in diagnosis, treatment protocols, and donor-to-recipient matching are needed to better define the oncological indications for transplantation. Prospective, multicenter trials studying these advances and their impact on outcomes are still required.https://www.mdpi.com/1648-9144/59/3/568peri-hilar cholangiocarcinomaintrahepatic cholangiocarcinomacolorectal liver metastasesneoadjuvant chemotherapyliver transplantation |
| spellingShingle | Silvia Quaresima Fabio Melandro Francesco Giovanardi Kejal Shah Valerio De Peppo Gianluca Mennini Davide Ghinolfi Ashley Limkemann Timothy M. Pawlik Quirino Lai New Insights in the Setting of Transplant Oncology Medicina peri-hilar cholangiocarcinoma intrahepatic cholangiocarcinoma colorectal liver metastases neoadjuvant chemotherapy liver transplantation |
| title | New Insights in the Setting of Transplant Oncology |
| title_full | New Insights in the Setting of Transplant Oncology |
| title_fullStr | New Insights in the Setting of Transplant Oncology |
| title_full_unstemmed | New Insights in the Setting of Transplant Oncology |
| title_short | New Insights in the Setting of Transplant Oncology |
| title_sort | new insights in the setting of transplant oncology |
| topic | peri-hilar cholangiocarcinoma intrahepatic cholangiocarcinoma colorectal liver metastases neoadjuvant chemotherapy liver transplantation |
| url | https://www.mdpi.com/1648-9144/59/3/568 |
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