Relationship of Blood Inflammatory Composite Markers with Cardiovascular Risk Factors and Subclinical Atherosclerosis in Patients with Rheumatoid Arthritis
The neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammatory index (SIRI, neutrophils × monocytes/lymphocytes) have been described as potential blood-derived inflammatory biomarkers in several diseases. Rheumatoid...
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MDPI AG
2023-06-01
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| Online Access: | https://www.mdpi.com/2075-1729/13/7/1469 |
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| author | Marta González-Sierra Adrián Quevedo-Rodríguez Alejandro Romo-Cordero Gaël González-Chretien Juan Carlos Quevedo-Abeledo Antonia de Vera-González Alejandra González-Delgado Candelaria Martín-González Miguel Ángel González-Gay Iván Ferraz-Amaro |
| author_facet | Marta González-Sierra Adrián Quevedo-Rodríguez Alejandro Romo-Cordero Gaël González-Chretien Juan Carlos Quevedo-Abeledo Antonia de Vera-González Alejandra González-Delgado Candelaria Martín-González Miguel Ángel González-Gay Iván Ferraz-Amaro |
| author_sort | Marta González-Sierra |
| collection | DOAJ |
| description | The neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammatory index (SIRI, neutrophils × monocytes/lymphocytes) have been described as potential blood-derived inflammatory biomarkers in several diseases. Rheumatoid arthritis is an inflammatory disease that has been related to an increased risk of cardiovascular (CV) disease. In the present work, we analyze how these hematological composite scores of inflammation are related to classic CV risk factors and subclinical atherosclerosis in patients with RA. In this cross-sectional study that included 430 patients with RA, the NLR, MLR, PLR, and SIRI scores were calculated. Multivariable analysis was performed to examine the relationships of these composite blood scores with subclinical carotid atherosclerosis and with traditional cardiovascular factors, producing a complete profile of lipid molecules and insulin resistance or indices of beta-cell function, and a Systematic Coronary Risk Assessment (SCORE2) calculation. C-reactive protein and disease activity were significantly and positively associated with the four blood composite scores. SCORE2 was significantly associated with higher values of SIRI, NLR, and MLR, but not PLR. These relationships were maintained when SCORE 2 was considered categorical; patients in the very high CV risk category had higher values in all hematological composite scores, except PLR. In the multivariable analysis, SIRI and NLR were independently associated with higher levels of beta cell dysfunction. In conclusion, SCORE2 and the values of the hematological composite scores were positively correlated in patients with RA. In addition, there were some relationships of these scores with traditional CV risk factors, with their association with beta cell dysfunction being the most consistent. |
| first_indexed | 2024-03-11T00:55:09Z |
| format | Article |
| id | doaj.art-c7e853bc2cd64b35b714589b6a93d985 |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-11T00:55:09Z |
| publishDate | 2023-06-01 |
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| series | Life |
| spelling | doaj.art-c7e853bc2cd64b35b714589b6a93d9852023-11-18T20:08:52ZengMDPI AGLife2075-17292023-06-01137146910.3390/life13071469Relationship of Blood Inflammatory Composite Markers with Cardiovascular Risk Factors and Subclinical Atherosclerosis in Patients with Rheumatoid ArthritisMarta González-Sierra0Adrián Quevedo-Rodríguez1Alejandro Romo-Cordero2Gaël González-Chretien3Juan Carlos Quevedo-Abeledo4Antonia de Vera-González5Alejandra González-Delgado6Candelaria Martín-González7Miguel Ángel González-Gay8Iván Ferraz-Amaro9Divsion of Hospitalization-at-Home, Hospital Universitario de Canarias, 38320 Tenerife, SpainDivision of Rheumatology, Hospital Universitario Dr. Negrín, 35010 Las Palmas de Gran Canaria, SpainDivision of Internal Medicine, Hospital Universitario de Canarias, 38320 Tenerife, SpainInternal Medicine Department, Universidad de La Laguna, 38200 Tenerife, SpainDivision of Rheumatology, Hospital Universitario Dr. Negrín, 35010 Las Palmas de Gran Canaria, SpainDivision of Central Laboratory, Hospital Universitario de Canarias, 38320 Tenerife, SpainDivision of Central Laboratory, Hospital Universitario de Canarias, 38320 Tenerife, SpainDivision of Internal Medicine, Hospital Universitario de Canarias, 38320 Tenerife, SpainDivision of Rheumatology, IIS-Fundación Jiménez Díaz, 28040 Madrid, SpainInternal Medicine Department, Universidad de La Laguna, 38200 Tenerife, SpainThe neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammatory index (SIRI, neutrophils × monocytes/lymphocytes) have been described as potential blood-derived inflammatory biomarkers in several diseases. Rheumatoid arthritis is an inflammatory disease that has been related to an increased risk of cardiovascular (CV) disease. In the present work, we analyze how these hematological composite scores of inflammation are related to classic CV risk factors and subclinical atherosclerosis in patients with RA. In this cross-sectional study that included 430 patients with RA, the NLR, MLR, PLR, and SIRI scores were calculated. Multivariable analysis was performed to examine the relationships of these composite blood scores with subclinical carotid atherosclerosis and with traditional cardiovascular factors, producing a complete profile of lipid molecules and insulin resistance or indices of beta-cell function, and a Systematic Coronary Risk Assessment (SCORE2) calculation. C-reactive protein and disease activity were significantly and positively associated with the four blood composite scores. SCORE2 was significantly associated with higher values of SIRI, NLR, and MLR, but not PLR. These relationships were maintained when SCORE 2 was considered categorical; patients in the very high CV risk category had higher values in all hematological composite scores, except PLR. In the multivariable analysis, SIRI and NLR were independently associated with higher levels of beta cell dysfunction. In conclusion, SCORE2 and the values of the hematological composite scores were positively correlated in patients with RA. In addition, there were some relationships of these scores with traditional CV risk factors, with their association with beta cell dysfunction being the most consistent.https://www.mdpi.com/2075-1729/13/7/1469rheumatoid arthritisblood composite inflammation scorescardiovascular disease |
| spellingShingle | Marta González-Sierra Adrián Quevedo-Rodríguez Alejandro Romo-Cordero Gaël González-Chretien Juan Carlos Quevedo-Abeledo Antonia de Vera-González Alejandra González-Delgado Candelaria Martín-González Miguel Ángel González-Gay Iván Ferraz-Amaro Relationship of Blood Inflammatory Composite Markers with Cardiovascular Risk Factors and Subclinical Atherosclerosis in Patients with Rheumatoid Arthritis Life rheumatoid arthritis blood composite inflammation scores cardiovascular disease |
| title | Relationship of Blood Inflammatory Composite Markers with Cardiovascular Risk Factors and Subclinical Atherosclerosis in Patients with Rheumatoid Arthritis |
| title_full | Relationship of Blood Inflammatory Composite Markers with Cardiovascular Risk Factors and Subclinical Atherosclerosis in Patients with Rheumatoid Arthritis |
| title_fullStr | Relationship of Blood Inflammatory Composite Markers with Cardiovascular Risk Factors and Subclinical Atherosclerosis in Patients with Rheumatoid Arthritis |
| title_full_unstemmed | Relationship of Blood Inflammatory Composite Markers with Cardiovascular Risk Factors and Subclinical Atherosclerosis in Patients with Rheumatoid Arthritis |
| title_short | Relationship of Blood Inflammatory Composite Markers with Cardiovascular Risk Factors and Subclinical Atherosclerosis in Patients with Rheumatoid Arthritis |
| title_sort | relationship of blood inflammatory composite markers with cardiovascular risk factors and subclinical atherosclerosis in patients with rheumatoid arthritis |
| topic | rheumatoid arthritis blood composite inflammation scores cardiovascular disease |
| url | https://www.mdpi.com/2075-1729/13/7/1469 |
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