Metabolic Phenotypes and Chronic Kidney Disease: A Cross-Sectional Assessment of Patients from a Large Federally Qualified Health Center
The purpose of this study is to determine if renal function varies by metabolic phenotype. A total of 9599 patients from a large Federally Qualified Health Center (FQHC) were included in the analysis. Metabolic health was classified as the absence of metabolic abnormalities defined by the National C...
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MDPI AG
2021-02-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/11/2/175 |
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| author | Kathleen E. Adair Nicholas von Waaden Matthew Rafalski Burritt W. Hess Sally P. Weaver Rodney G. Bowden |
| author_facet | Kathleen E. Adair Nicholas von Waaden Matthew Rafalski Burritt W. Hess Sally P. Weaver Rodney G. Bowden |
| author_sort | Kathleen E. Adair |
| collection | DOAJ |
| description | The purpose of this study is to determine if renal function varies by metabolic phenotype. A total of 9599 patients from a large Federally Qualified Health Center (FQHC) were included in the analysis. Metabolic health was classified as the absence of metabolic abnormalities defined by the National Cholesterol Education Program Adult Treatment Panel III criteria, excluding waist circumference. Obesity was defined as body mass index >30 kg/m<sup>2</sup> and renal health as an estimated glomerular filtration rate (eGFR) >60 mL/min/1.73 m<sup>2</sup>. Linear and logistic regressions were used to analyze the data. The metabolically healthy overweight (MHO) phenotype had the highest eGFR (104.86 ± 28.76 mL/min/1.72 m<sup>2</sup>) and lowest unadjusted odds of chronic kidney disease (CKD) (OR = 0.46, 95%CI = 0.168, 1.267, <i>p</i> = 0.133), while the metabolically unhealthy normal weight (MUN) phenotype demonstrated the lowest eGFR (91.34 ± 33.28 mL/min/1.72 m<sup>2</sup>) and the highest unadjusted odds of CKD (OR = 3.63, <i>p</i> < 0.0001). After controlling for age, sex, and smoking status, the metabolically unhealthy obese (MUO) (OR = 1.80, 95%CI = 1.08, 3.00, <i>p</i> = 0.024) was the only phenotype with significantly higher odds of CKD as compared to the reference. We demonstrate that the metabolically unhealthy phenotypes have the highest odds of CKD compared to metabolically healthy individuals. |
| first_indexed | 2024-03-09T00:35:51Z |
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| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-09T00:35:51Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-c7e93e51ae46448e9ae9e570bcce8f892023-12-11T18:10:38ZengMDPI AGLife2075-17292021-02-0111217510.3390/life11020175Metabolic Phenotypes and Chronic Kidney Disease: A Cross-Sectional Assessment of Patients from a Large Federally Qualified Health CenterKathleen E. Adair0Nicholas von Waaden1Matthew Rafalski2Burritt W. Hess3Sally P. Weaver4Rodney G. Bowden5Department of Health, Human Performance, and Recreation, Baylor University, Waco, TX 76798, USADepartment of Health, Human Performance, and Recreation, Baylor University, Waco, TX 76798, USAFamily Health Center, Waco, TX 76707, USAFamily Health Center, Waco, TX 76707, USAFamily Health Center, Waco, TX 76707, USARobbins College of Health and Human Sciences, Baylor University, Waco, TX 76798, USAThe purpose of this study is to determine if renal function varies by metabolic phenotype. A total of 9599 patients from a large Federally Qualified Health Center (FQHC) were included in the analysis. Metabolic health was classified as the absence of metabolic abnormalities defined by the National Cholesterol Education Program Adult Treatment Panel III criteria, excluding waist circumference. Obesity was defined as body mass index >30 kg/m<sup>2</sup> and renal health as an estimated glomerular filtration rate (eGFR) >60 mL/min/1.73 m<sup>2</sup>. Linear and logistic regressions were used to analyze the data. The metabolically healthy overweight (MHO) phenotype had the highest eGFR (104.86 ± 28.76 mL/min/1.72 m<sup>2</sup>) and lowest unadjusted odds of chronic kidney disease (CKD) (OR = 0.46, 95%CI = 0.168, 1.267, <i>p</i> = 0.133), while the metabolically unhealthy normal weight (MUN) phenotype demonstrated the lowest eGFR (91.34 ± 33.28 mL/min/1.72 m<sup>2</sup>) and the highest unadjusted odds of CKD (OR = 3.63, <i>p</i> < 0.0001). After controlling for age, sex, and smoking status, the metabolically unhealthy obese (MUO) (OR = 1.80, 95%CI = 1.08, 3.00, <i>p</i> = 0.024) was the only phenotype with significantly higher odds of CKD as compared to the reference. We demonstrate that the metabolically unhealthy phenotypes have the highest odds of CKD compared to metabolically healthy individuals.https://www.mdpi.com/2075-1729/11/2/175metabolic syndromemetabolic phenotypesobesitychronic kidney diseaserenal disease |
| spellingShingle | Kathleen E. Adair Nicholas von Waaden Matthew Rafalski Burritt W. Hess Sally P. Weaver Rodney G. Bowden Metabolic Phenotypes and Chronic Kidney Disease: A Cross-Sectional Assessment of Patients from a Large Federally Qualified Health Center Life metabolic syndrome metabolic phenotypes obesity chronic kidney disease renal disease |
| title | Metabolic Phenotypes and Chronic Kidney Disease: A Cross-Sectional Assessment of Patients from a Large Federally Qualified Health Center |
| title_full | Metabolic Phenotypes and Chronic Kidney Disease: A Cross-Sectional Assessment of Patients from a Large Federally Qualified Health Center |
| title_fullStr | Metabolic Phenotypes and Chronic Kidney Disease: A Cross-Sectional Assessment of Patients from a Large Federally Qualified Health Center |
| title_full_unstemmed | Metabolic Phenotypes and Chronic Kidney Disease: A Cross-Sectional Assessment of Patients from a Large Federally Qualified Health Center |
| title_short | Metabolic Phenotypes and Chronic Kidney Disease: A Cross-Sectional Assessment of Patients from a Large Federally Qualified Health Center |
| title_sort | metabolic phenotypes and chronic kidney disease a cross sectional assessment of patients from a large federally qualified health center |
| topic | metabolic syndrome metabolic phenotypes obesity chronic kidney disease renal disease |
| url | https://www.mdpi.com/2075-1729/11/2/175 |
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