Time-resolved proximity labeling of protein networks associated with ligand-activated EGFR

Time-resolved proximity labeling of protein networks associated with ligand-activated EGFR

Summary: Ligand binding to the EGF receptor (EGFR) triggers multiple signal-transduction processes and promotes endocytosis of the receptor. The mechanisms of EGFR endocytosis and its cross-talk with signaling are poorly understood. Here, we combine peroxidase-catalyzed proximity labeling, isobaric...

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Bibliographic Details
Main Authors: Mireia Perez Verdaguer, Tian Zhang, Sachin Surve, Joao A. Paulo, Callen Wallace, Simon C. Watkins, Steven P. Gygi, Alexander Sorkin
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:Cell Reports
Subjects:
EGF receptor
proximity labeling
endocytosis
signaling
Online Access:http://www.sciencedirect.com/science/article/pii/S221112472200732X

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