$Systemic and Peripheral Mechanisms of Cortical Stimulation-Induced Analgesia and Refractoriness in a Rat Model of Neuropathic Pain$

Systemic and Peripheral Mechanisms of Cortical Stimulation-Induced Analgesia and Refractoriness in a Rat Model of Neuropathic Pain

Epidural motor cortex stimulation (MCS) is an effective treatment for refractory neuropathic pain; however, some individuals are unresponsive. In this study, we correlated the effectiveness of MCS and refractoriness with the expression of cytokines, neurotrophins, and nociceptive mediators in the do...

Full description

Bibliographic Details
Main Authors:	Danielle V. Assis, Ana Carolina P. Campos, Amanda F. N. Paschoa, Talita F. Santos, Erich T. Fonoff, Rosana L. Pagano
Format:	Article
Language:	English
Published:	MDPI AG 2023-04-01
Series:	International Journal of Molecular Sciences
Subjects:	motor cortex stimulation neuropathic pain sciatic nerve inflammation neurotrophins substance P
Online Access:	https://www.mdpi.com/1422-0067/24/9/7796

Similar Items

Preventive Intrathecal Injection of Bupivacaine Alleviated Microglia Activation and Neuropathic Pain in a Rat Model of Chronic Constriction Injury
by: Chih-Cheng Wu, et al.
Published: (2022-06-01)

The Effect of Anakinra on Acrylamide-induced Peripheral Neuropathy and Neuropathic Pain in Rats
by: Alevtina Ersoy, et al.
Published: (2023-01-01)

Caraway Oil as a Multimodal Therapy for Neuropathic Pain: Investigating the Mechanisms of Action in Rats with Chronic Constriction Injury
by: Faisal K. Alkholifi, et al.
Published: (2023-02-01)

Silencing of secreted phosphoprotein 1 attenuates sciatic nerve injury‐induced neuropathic pain: Regulating extracellular signal‐regulated kinase and neuroinflammatory signaling pathways
by: Haiyu Xie, et al.
Published: (2024-02-01)

Adenosine A2A Receptor Agonist, Polydeoxyribonucleotide Treatment Improves Locomotor Function and Thermal Hyperalgesia Following Neuropathic Pain in Rats
by: Ye Chan Joo, et al.
Published: (2023-12-01)

Pharmacological blockade of cannabinoid type II receptors and mesenchymal stem cell transplantation in a model of peripheral neuropathic pain
by: A.-M. V. Yerofeyeva, et al.
Published: (2024-01-01)

Endoscopic surgery for managing sciatic nerve pathology: first results, possibilities, complications: а case series
by: Evgeniy A. Belyak, et al.
Published: (2023-06-01)

CD206+/MHCII− macrophage accumulation at nerve injury site correlates with attenuation of allodynia in TASTPM mouse model of Alzheimer's disease
by: Rita Silva, et al.
Published: (2022-12-01)

Editorial: Surgical treatment of peripheral neuropathic pain, peripheral nerve tumors, and peripheral nerve injury
by: Yanzhao Dong, et al.
Published: (2023-08-01)

Pathophysiology and biomechanics of stretch-induced peripheral nerve injuries
by: Yulia V. Karakulova, et al.
Published: (2023-09-01)

Veratramine ameliorates pain symptoms in rats with diabetic peripheral neuropathy by inhibiting activation of the SIGMAR1-NMDAR pathway
by: Yu Zhang, et al.
Published: (2022-12-01)

Transcriptomic and proteomic profiling of the anterior cingulate cortex in neuropathic pain model rats
by: Xin-Tong Qiu, et al.
Published: (2023-06-01)

Loss of cortical control over the descending pain modulatory system determines the development of the neuropathic pain state in rats
by: Robert AR Drake, et al.
Published: (2021-02-01)

Exploring gene signatures and regulatory networks in a rat model of sciatica: implications and validation in neuropathic pain
by: Mu Xu, et al.
Published: (2024-02-01)

Astrocyte senescence-like response related to peripheral nerve injury-induced neuropathic pain
by: Jingyi Du, et al.
Published: (2023-08-01)

Retraction Notice: “Assessment Results of Surgical Treatment of Sciatic Nerve Injuries”. Traumatology and Orthopedics of Russia. 2009;(1):96-98
by: Ruslan I. Khamzaev, et al.
Published: (2022-06-01)

Assessment of focused ultrasound stimulation to induce peripheral nerve activity and potential damage in vivo
by: Bruno Rodríguez-Meana, et al.
Published: (2024-02-01)

Increased visceral pain responsiveness in female mice compared to male mice afer partial sciatic nerve ligation
by: M.SH Meimandi, et al.
Published: (2002-09-01)

The Neuropeptide Cortistatin Alleviates Neuropathic Pain in Experimental Models of Peripheral Nerve Injury
by: Clara P. Falo, et al.
Published: (2021-06-01)

Inhibitory insula-ACC projections modulate affective but not sensory aspects of neuropathic pain
by: Heloísa Alonso-Matielo, et al.
Published: (2023-08-01)

Peripheral mechanisms of peripheral neuropathic pain
by: Paola Pacifico, et al.
Published: (2023-09-01)

Neuropathic Changes of Osmicated Common Peroneal and Tibial Nerve in Diabetic Patients and the Related Risk Factors
by: Payman Jamal Muhamad Ameen, et al.
Published: (2019-11-01)

Neuropathic Changes of Osmicated Common Peroneal and Tibial Nerve in Diabetic Patients and the Related Risk Factors
by: Payman Jamal Muhamad Ameen, et al.
Published: (2019-11-01)

In Vitro and In Vivo Effects of Flavonoids on Peripheral Neuropathic Pain
by: Paramita Basu, et al.
Published: (2020-03-01)

Teneligliptin Exerts Antinociceptive Effects in Rat Model of Partial Sciatic Nerve Transection Induced Neuropathic Pain
by: Yaswanth Kuthati, et al.
Published: (2021-09-01)

Tuina for peripherally-induced neuropathic pain: A review of analgesic mechanism
by: Zhi-Feng Liu, et al.
Published: (2022-12-01)

Efficacy of continuous catheter analgesia of the sciatic nerve after total knee arthroplasty
by: Jan P. Benthien, et al.
Published: (2015-02-01)

Pathophysiology of Post-Traumatic Trigeminal Neuropathic Pain
by: Olga A. Korczeniewska, et al.
Published: (2022-11-01)

A Review on Autophagy in Orofacial Neuropathic Pain
by: Mayank Shrivastava, et al.
Published: (2022-11-01)

A study of 62 cases of sciatic nerve injury
by: Ali K. AL-Shalchy
Published: (2009-04-01)

Neurotrophic Factors in Experimental Cerebral Acanthamoebiasis
by: Natalia Łanocha-Arendarczyk, et al.
Published: (2022-04-01)

Crotoxin Conjugated to SBA-15 Nanostructured Mesoporous Silica Induces Long-Last Analgesic Effect in the Neuropathic Pain Model in Mice
by: Morena Brazil Sant’Anna, et al.
Published: (2019-11-01)

Synergistic Suppression of NF1 Malignant Peripheral Nerve Sheath Tumor Cell Growth in Culture and Orthotopic Xenografts by Combinational Treatment with Statin and Prodrug Farnesyltransferase Inhibitor PAMAM G4 Dendrimers
by: John J. Reiners, et al.
Published: (2023-12-01)

Olfactory ensheathing cells and neuropathic pain
by: Ji-peng Liu, et al.
Published: (2023-04-01)

Augmenting Peripheral Nerve Regeneration Using Hair Follicle Stem Cells in Rats
by: Leila Beigom Hejazian, et al.
Published: (2022-01-01)

The Time Course of MHC-I Expression in C57BL/6J and A/J Mice Correlates with the Degree of Retrograde Gliosis in the Spinal Cord following Sciatic Nerve Crush
by: Bruno Henrique de Melo Lima, et al.
Published: (2022-11-01)

Distribution of Sciatic nerve in Hamstring muscles
by: "Khaleghi R, et al.
Published: (2000-09-01)

Neural Plasticity in the Brain during Neuropathic Pain
by: Myeong Seong Bak, et al.
Published: (2021-05-01)

Local infiltration of analgesia and sciatic nerve block provide similar pain relief after total knee arthroplasty
by: Hidenori Tanikawa, et al.
Published: (2017-07-01)

Expression profiles of TRPV1, TRPV4, TLR4 and ERK1/2 in the dorsal root ganglionic neurons of a cancer-induced neuropathy rat model
by: Ahmad Maqboul, et al.
Published: (2018-04-01)