Systemic and Peripheral Mechanisms of Cortical Stimulation-Induced Analgesia and Refractoriness in a Rat Model of Neuropathic Pain

Systemic and Peripheral Mechanisms of Cortical Stimulation-Induced Analgesia and Refractoriness in a Rat Model of Neuropathic Pain

Epidural motor cortex stimulation (MCS) is an effective treatment for refractory neuropathic pain; however, some individuals are unresponsive. In this study, we correlated the effectiveness of MCS and refractoriness with the expression of cytokines, neurotrophins, and nociceptive mediators in the do...

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Bibliographic Details
Main Authors: Danielle V. Assis, Ana Carolina P. Campos, Amanda F. N. Paschoa, Talita F. Santos, Erich T. Fonoff, Rosana L. Pagano
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:International Journal of Molecular Sciences
Subjects:
motor cortex stimulation
neuropathic pain
sciatic nerve
inflammation
neurotrophins
substance P
Online Access:https://www.mdpi.com/1422-0067/24/9/7796

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