Decrease of invasive pneumococcal disease (IPD) in adults after introduction of pneumococcal 13-valent conjugate vaccine in Spain.
A prospective laboratory-based multicenter study that collected all adult invasive pneumococcal disease (IPD) episodes from 6 Spanish hospitals before (2008-2009) and after (2012-2013). The 13-valent pneumococcal conjugate vaccine (PCV13) licensure was conducted in order to analyze the impact of PCV...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2017-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5383258?pdf=render |
| _version_ | 1818050543677865984 |
|---|---|
| author | Jordi Càmara José María Marimón Emilia Cercenado Nieves Larrosa María Dolores Quesada Dionísia Fontanals Meritxell Cubero Emilio Pérez-Trallero Asunción Fenoll Josefina Liñares Carmen Ardanuy |
| author_facet | Jordi Càmara José María Marimón Emilia Cercenado Nieves Larrosa María Dolores Quesada Dionísia Fontanals Meritxell Cubero Emilio Pérez-Trallero Asunción Fenoll Josefina Liñares Carmen Ardanuy |
| author_sort | Jordi Càmara |
| collection | DOAJ |
| description | A prospective laboratory-based multicenter study that collected all adult invasive pneumococcal disease (IPD) episodes from 6 Spanish hospitals before (2008-2009) and after (2012-2013). The 13-valent pneumococcal conjugate vaccine (PCV13) licensure was conducted in order to analyze the impact of PCV13 introduction for children on adult IPD. A total of 1558 IPD episodes were detected. The incidence of IPD decreased significantly in the second period by -33.9% (95% CI, -40.3% to -26.8%). IPD due to PCV7 serotypes (-52.7%; 95% CI, -64.2% to -37.5%) and to PCV13 additional serotypes (-55.0% 95% CI, -62.0% to -46.7%) significantly decreased whereas IPD due to non-PCV13 serotypes remained stable (1.0% 95% CI, -12.9% to 17.2%). IPD due to all PCV13 additional serotypes significantly declined with the exception of serotype 3 (-11.3%; 95%CI -35.0% to 21.1%). IPD due to two non-PCV13 serotypes varied: serotype 6C that rose (301.6%; 95%CI, 92.7% to 733.3%, p<0.001), related to the expansion of ST3866C, and serotype 8 that decreased (-34.9%, 95%CI, -57.1 to -1.2, p = 0.049), related to a decline of the ST638. The recombinant clone ST652111A (variant of ST1569V) increased in frequency. The decrease of serotype 19A IPD was linked to a fall in those antibiotic susceptible clones. In the last period, rates of penicillin- and cefotaxime-resistance remained under 10% and 4%, respectively. Adult IPD decreased after the PCV13 introduction in Spain due to herd protection. The spread of multidrug resistant clones (ST3866C, ST652111A) related to non-PCV13 serotypes needs further surveillance. |
| first_indexed | 2024-12-10T10:55:09Z |
| format | Article |
| id | doaj.art-c7eaa19e0fae4b79a9fe64e9c8559863 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-10T10:55:09Z |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-c7eaa19e0fae4b79a9fe64e9c85598632022-12-22T01:51:55ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01124e017522410.1371/journal.pone.0175224Decrease of invasive pneumococcal disease (IPD) in adults after introduction of pneumococcal 13-valent conjugate vaccine in Spain.Jordi CàmaraJosé María MarimónEmilia CercenadoNieves LarrosaMaría Dolores QuesadaDionísia FontanalsMeritxell CuberoEmilio Pérez-TralleroAsunción FenollJosefina LiñaresCarmen ArdanuyA prospective laboratory-based multicenter study that collected all adult invasive pneumococcal disease (IPD) episodes from 6 Spanish hospitals before (2008-2009) and after (2012-2013). The 13-valent pneumococcal conjugate vaccine (PCV13) licensure was conducted in order to analyze the impact of PCV13 introduction for children on adult IPD. A total of 1558 IPD episodes were detected. The incidence of IPD decreased significantly in the second period by -33.9% (95% CI, -40.3% to -26.8%). IPD due to PCV7 serotypes (-52.7%; 95% CI, -64.2% to -37.5%) and to PCV13 additional serotypes (-55.0% 95% CI, -62.0% to -46.7%) significantly decreased whereas IPD due to non-PCV13 serotypes remained stable (1.0% 95% CI, -12.9% to 17.2%). IPD due to all PCV13 additional serotypes significantly declined with the exception of serotype 3 (-11.3%; 95%CI -35.0% to 21.1%). IPD due to two non-PCV13 serotypes varied: serotype 6C that rose (301.6%; 95%CI, 92.7% to 733.3%, p<0.001), related to the expansion of ST3866C, and serotype 8 that decreased (-34.9%, 95%CI, -57.1 to -1.2, p = 0.049), related to a decline of the ST638. The recombinant clone ST652111A (variant of ST1569V) increased in frequency. The decrease of serotype 19A IPD was linked to a fall in those antibiotic susceptible clones. In the last period, rates of penicillin- and cefotaxime-resistance remained under 10% and 4%, respectively. Adult IPD decreased after the PCV13 introduction in Spain due to herd protection. The spread of multidrug resistant clones (ST3866C, ST652111A) related to non-PCV13 serotypes needs further surveillance.http://europepmc.org/articles/PMC5383258?pdf=render |
| spellingShingle | Jordi Càmara José María Marimón Emilia Cercenado Nieves Larrosa María Dolores Quesada Dionísia Fontanals Meritxell Cubero Emilio Pérez-Trallero Asunción Fenoll Josefina Liñares Carmen Ardanuy Decrease of invasive pneumococcal disease (IPD) in adults after introduction of pneumococcal 13-valent conjugate vaccine in Spain. PLoS ONE |
| title | Decrease of invasive pneumococcal disease (IPD) in adults after introduction of pneumococcal 13-valent conjugate vaccine in Spain. |
| title_full | Decrease of invasive pneumococcal disease (IPD) in adults after introduction of pneumococcal 13-valent conjugate vaccine in Spain. |
| title_fullStr | Decrease of invasive pneumococcal disease (IPD) in adults after introduction of pneumococcal 13-valent conjugate vaccine in Spain. |
| title_full_unstemmed | Decrease of invasive pneumococcal disease (IPD) in adults after introduction of pneumococcal 13-valent conjugate vaccine in Spain. |
| title_short | Decrease of invasive pneumococcal disease (IPD) in adults after introduction of pneumococcal 13-valent conjugate vaccine in Spain. |
| title_sort | decrease of invasive pneumococcal disease ipd in adults after introduction of pneumococcal 13 valent conjugate vaccine in spain |
| url | http://europepmc.org/articles/PMC5383258?pdf=render |
| work_keys_str_mv | AT jordicamara decreaseofinvasivepneumococcaldiseaseipdinadultsafterintroductionofpneumococcal13valentconjugatevaccineinspain AT josemariamarimon decreaseofinvasivepneumococcaldiseaseipdinadultsafterintroductionofpneumococcal13valentconjugatevaccineinspain AT emiliacercenado decreaseofinvasivepneumococcaldiseaseipdinadultsafterintroductionofpneumococcal13valentconjugatevaccineinspain AT nieveslarrosa decreaseofinvasivepneumococcaldiseaseipdinadultsafterintroductionofpneumococcal13valentconjugatevaccineinspain AT mariadoloresquesada decreaseofinvasivepneumococcaldiseaseipdinadultsafterintroductionofpneumococcal13valentconjugatevaccineinspain AT dionisiafontanals decreaseofinvasivepneumococcaldiseaseipdinadultsafterintroductionofpneumococcal13valentconjugatevaccineinspain AT meritxellcubero decreaseofinvasivepneumococcaldiseaseipdinadultsafterintroductionofpneumococcal13valentconjugatevaccineinspain AT emiliopereztrallero decreaseofinvasivepneumococcaldiseaseipdinadultsafterintroductionofpneumococcal13valentconjugatevaccineinspain AT asuncionfenoll decreaseofinvasivepneumococcaldiseaseipdinadultsafterintroductionofpneumococcal13valentconjugatevaccineinspain AT josefinalinares decreaseofinvasivepneumococcaldiseaseipdinadultsafterintroductionofpneumococcal13valentconjugatevaccineinspain AT carmenardanuy decreaseofinvasivepneumococcaldiseaseipdinadultsafterintroductionofpneumococcal13valentconjugatevaccineinspain |