N6-methyladenosine-modified oncofetal lncRNA MIR4435-2HG contributed to stemness features of hepatocellular carcinoma cells by regulating rRNA 2′-O methylation

N6-methyladenosine-modified oncofetal lncRNA MIR4435-2HG contributed to stemness features of hepatocellular carcinoma cells by regulating rRNA 2′-O methylation

Abstract Background The unique expression pattern endows oncofetal genes with great value in cancer diagnosis and treatment. However, only a few oncofetal genes are available for clinical use and the underlying mechanisms that drives the fetal-like reprogramming of cancer cells remain largely unknow...

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Bibliographic Details
Main Authors: Yiqing Zhu, Bang Xiao, Meng Liu, Meiting Chen, Ningqi Xia, Haiyan Guo, Jinfeng Huang, Zhiyong Liu, Fang Wang
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Cellular & Molecular Biology Letters
Subjects:
Oncofetal lncRNA
Hepatocellular carcinoma
Stemness maintenance
rRNA 2′-O-methylation
N6-methyladenosine
Online Access:https://doi.org/10.1186/s11658-023-00493-2

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