IL10-Deficiency in CD4+ T Cells Exacerbates the IFNγ and IL17 Response During Bacteria Induced Colitis

IL10-Deficiency in CD4+ T Cells Exacerbates the IFNγ and IL17 Response During Bacteria Induced Colitis

Background/Aims: IL10 is a key inhibitor of effector T cell activation and a mediator of intestinal homeostasis. In addition, IL10 has emerged as a key immunoregulator during infection with various pathogens, ameliorating the excessive T-cell responses that are responsible for much of the immunopath...

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Bibliographic Details
Main Authors: Virginia Seiffart, Julia Zoeller, Robert Klopfleisch, Munisch Wadwa, Wiebke Hansen, Jan Buer, Christian Riedel, Astrid M. Westendorf
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2015-07-01
Series:Cellular Physiology and Biochemistry
Subjects:
Citrobacter rodentium
Interleukin 10
T helper cell 17
Colitis
Online Access:http://www.karger.com/Article/FullText/430295

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