Transcriptome network analysis implicates CX3CR1-positive type 3 dendritic cells in non-infectious uveitis

Transcriptome network analysis implicates CX3CR1-positive type 3 dendritic cells in non-infectious uveitis

Background: Type I interferons (IFNs) promote the expansion of subsets of CD1c+ conventional dendritic cells (CD1c+ DCs), but the molecular basis of CD1c+ DCs involvement in conditions not associated without elevated type I IFNs remains unclear. Methods: We analyzed CD1c+ DCs from two cohorts of non...

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Main Authors: Sanne Hiddingh, Aridaman Pandit, Fleurieke Verhagen, Rianne Rijken, Nila Hendrika Servaas, Rina CGK Wichers, Ninette H ten Dam-van Loon, Saskia M Imhof, Timothy RDJ Radstake, Joke H de Boer, Jonas JW Kuiper
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-04-01
Series:eLife
Subjects:
dendritic cells
autoimmune response/disease
uveitis
CD1c
RNA-seq
interferons
Online Access:https://elifesciences.org/articles/74913

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