Resident bacteria contribute to opportunistic infections of the respiratory tract.
Opportunistic pathogens frequently cause volatile infections in hosts with compromised immune systems or a disrupted normal microbiota. The commensalism of diverse microorganisms contributes to colonization resistance, which prevents the expansion of opportunistic pathogens. Following microbiota dis...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2021-03-01
|
| Series: | PLoS Pathogens |
| Online Access: | https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1009436&type=printable |
| _version_ | 1826554774198157312 |
|---|---|
| author | Yifan Wu Yongqiang Wang Huiming Yang Qian Li Xiaoxia Gong Guozhong Zhang Kui Zhu |
| author_facet | Yifan Wu Yongqiang Wang Huiming Yang Qian Li Xiaoxia Gong Guozhong Zhang Kui Zhu |
| author_sort | Yifan Wu |
| collection | DOAJ |
| description | Opportunistic pathogens frequently cause volatile infections in hosts with compromised immune systems or a disrupted normal microbiota. The commensalism of diverse microorganisms contributes to colonization resistance, which prevents the expansion of opportunistic pathogens. Following microbiota disruption, pathogens promptly adapt to altered niches and obtain growth advantages. Nevertheless, whether and how resident bacteria modulate the growth dynamics of invasive pathogens and the eventual outcome of such infections are still unclear. Here, we utilized birds as a model animal and observed a resident bacterium exacerbating the invasion of Avibacterium paragallinarum (previously Haemophilus paragallinarum) in the respiratory tract. We first found that negligibly abundant Staphylococcus chromogenes, rather than Staphylococcus aureus, played a dominant role in Av. paragallinarum-associated infectious coryza in poultry based on epidemic investigations and in vitro analyses. Furthermore, we determined that S. chromogenes not only directly provides the necessary nutrition factor nicotinamide adenine dinucleotide (NAD+) but also accelerates its biosynthesis and release from host cells to promote the survival and growth of Av. paragallinarum. Last, we successfully intervened in Av. paragallinarum-associated infections in animal models using antibiotics that specifically target S. chromogenes. Our findings show that opportunistic pathogens can hijack commensal bacteria to initiate infection and expansion and suggest a new paradigm to ameliorate opportunistic infections by modulating the dynamics of resident bacteria. |
| first_indexed | 2024-12-22T11:53:45Z |
| format | Article |
| id | doaj.art-c7edee0ea8854be7bb009cfec92691c4 |
| institution | Directory Open Access Journal |
| issn | 1553-7366 1553-7374 |
| language | English |
| last_indexed | 2025-03-14T07:46:15Z |
| publishDate | 2021-03-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Pathogens |
| spelling | doaj.art-c7edee0ea8854be7bb009cfec92691c42025-03-03T05:32:26ZengPublic Library of Science (PLoS)PLoS Pathogens1553-73661553-73742021-03-01173e100943610.1371/journal.ppat.1009436Resident bacteria contribute to opportunistic infections of the respiratory tract.Yifan WuYongqiang WangHuiming YangQian LiXiaoxia GongGuozhong ZhangKui ZhuOpportunistic pathogens frequently cause volatile infections in hosts with compromised immune systems or a disrupted normal microbiota. The commensalism of diverse microorganisms contributes to colonization resistance, which prevents the expansion of opportunistic pathogens. Following microbiota disruption, pathogens promptly adapt to altered niches and obtain growth advantages. Nevertheless, whether and how resident bacteria modulate the growth dynamics of invasive pathogens and the eventual outcome of such infections are still unclear. Here, we utilized birds as a model animal and observed a resident bacterium exacerbating the invasion of Avibacterium paragallinarum (previously Haemophilus paragallinarum) in the respiratory tract. We first found that negligibly abundant Staphylococcus chromogenes, rather than Staphylococcus aureus, played a dominant role in Av. paragallinarum-associated infectious coryza in poultry based on epidemic investigations and in vitro analyses. Furthermore, we determined that S. chromogenes not only directly provides the necessary nutrition factor nicotinamide adenine dinucleotide (NAD+) but also accelerates its biosynthesis and release from host cells to promote the survival and growth of Av. paragallinarum. Last, we successfully intervened in Av. paragallinarum-associated infections in animal models using antibiotics that specifically target S. chromogenes. Our findings show that opportunistic pathogens can hijack commensal bacteria to initiate infection and expansion and suggest a new paradigm to ameliorate opportunistic infections by modulating the dynamics of resident bacteria.https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1009436&type=printable |
| spellingShingle | Yifan Wu Yongqiang Wang Huiming Yang Qian Li Xiaoxia Gong Guozhong Zhang Kui Zhu Resident bacteria contribute to opportunistic infections of the respiratory tract. PLoS Pathogens |
| title | Resident bacteria contribute to opportunistic infections of the respiratory tract. |
| title_full | Resident bacteria contribute to opportunistic infections of the respiratory tract. |
| title_fullStr | Resident bacteria contribute to opportunistic infections of the respiratory tract. |
| title_full_unstemmed | Resident bacteria contribute to opportunistic infections of the respiratory tract. |
| title_short | Resident bacteria contribute to opportunistic infections of the respiratory tract. |
| title_sort | resident bacteria contribute to opportunistic infections of the respiratory tract |
| url | https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1009436&type=printable |
| work_keys_str_mv | AT yifanwu residentbacteriacontributetoopportunisticinfectionsoftherespiratorytract AT yongqiangwang residentbacteriacontributetoopportunisticinfectionsoftherespiratorytract AT huimingyang residentbacteriacontributetoopportunisticinfectionsoftherespiratorytract AT qianli residentbacteriacontributetoopportunisticinfectionsoftherespiratorytract AT xiaoxiagong residentbacteriacontributetoopportunisticinfectionsoftherespiratorytract AT guozhongzhang residentbacteriacontributetoopportunisticinfectionsoftherespiratorytract AT kuizhu residentbacteriacontributetoopportunisticinfectionsoftherespiratorytract |